PROSTATE CARCINOMA

This study tests whether the drug olaparib can help control aggressive variant prostate cancer when given after initial chemotherapy. About 96 men will receive cabazitaxel, carboplatin, and prednisone, then either olaparib or observation. The goal is to see if olaparib delays can…

This study tests whether green tea catechins (natural compounds found in green tea) can prevent low-risk prostate cancer from getting worse in men who are closely monitoring their condition instead of undergoing immediate treatment. About 360 men will take either green tea catech…

This study compares two types of brachytherapy (radiation implants) for men with early-stage prostate cancer that hasn't spread. One uses high-dose radiation given in two sessions, the other uses low-dose radiation from permanent seeds. The goal is to see how well each controls c…

This study tests whether adding darolutamide to standard hormone therapy (ADT) after prostate removal surgery can delay or prevent cancer from spreading in men at highest risk. About 27 participants will receive either darolutamide or a placebo alongside ADT. The goal is to see i…

This is a first-in-human study to test the safety and find the right dose of an experimental pill called ATV-1601. It is for adults with advanced solid tumors, including certain breast, gynecologic, and prostate cancers, that have a specific genetic change called an AKT1 E17K mut…

This study explores whether a PET scan using a special tracer (68Ga-PSMA-11) can help guide prostate biopsies to find serious prostate cancer more accurately. It involves 30 men who had a previous biopsy that was negative or unclear. The goal is to improve detection and reduce bo…

This study tests whether a new device called the OmnEcoil system can safely and effectively combine two separate procedures—MRI imaging and biopsy—into one session for diagnosing prostate cancer. The device uses a special coil placed in the rectum to take high-quality images and …

This study tests whether a special MRI technique called Dixon can produce clearer images of prostate cancer than standard MRI. About 65 men with prostate cancer who are already scheduled for prostate removal will get both types of MRI scans. The goal is to see if the Dixon method…

This study tests a new 3D MRI technique to see if it can find prostate cancer better than standard MRI, without needing a special coil inside the body. About 33 men with untreated, intermediate- or high-risk prostate cancer will be scanned before surgery. The goal is to improve h…

This study was designed to see if a special PET/MRI scan can better detect serious prostate cancer in men with elevated PSA levels. Participants would have received an injectable radioactive tracer that attaches to prostate cancer cells, followed by imaging. The goal was to compa…

This study tests whether a special whole-body MRI can better detect if high-risk prostate cancer has spread to bones or lymph nodes. About 98 men with high-risk prostate cancer will get this MRI along with standard bone and CT scans. The goal is to see if the MRI is more accurate…

This study looks at whether a special type of MRI, called multiparametric MRI, can more accurately determine the stage of prostate cancer in people recently diagnosed. The goal is to help doctors better identify aggressive cancers and plan the right surgery. About 850 participant…

This study tests whether a special ultrasound contrast agent (tiny gas bubbles) can help doctors see prostate cancer on ultrasound images. The goal is to find a non-invasive way to diagnose prostate cancer, avoiding the need for a needle biopsy. The study involves 70 men who are …

This study tests whether blocking certain arteries in the prostate (called prostatic artery embolization) can reduce urinary symptoms in men with early-stage prostate cancer who are about to get radiation therapy. Seventeen men will receive the procedure and then be followed for …

This study looks at whether having an empty bladder before prostate cancer radiation therapy is better than a full bladder. Usually, patients are asked to have a full bladder to protect nearby organs, but this can be hard to maintain and cause stress. The trial will compare urina…

This study tests whether combining a stimulant drug (methylphenidate) with an exercise program can reduce severe fatigue in prostate cancer patients receiving hormone therapy and radiation. About 200 participants will be assigned to different groups to compare the effects. The go…

This study tests whether a new PET-CT scanner can produce clear images of prostate cancer tumors, similar to the standard scan. About 34 adults with prostate cancer will get both scans to compare. If the new scanner works well, it could allow doctors to plan radiation therapy usi…

This study looks at inherited gene mutations (like BRCA1 and BRCA2) in men with prostate cancer. Researchers will collect saliva samples and health information from 1,360 men in Washington state. The goal is to understand how these mutations affect cancer treatment and to help fa…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study looked at whether regular screening tests for prostate, lung, colorectal, and ovarian cancers can help find cancer early and reduce the number of people who die from these cancers. Over 76,000 men and women took part, with some getting routine screening and others gett…

This study aims to understand how social factors like immigration background affect health decisions and prostate cancer care among Sub-Saharan African and Caribbean immigrant men. Researchers will interview 80 men diagnosed with prostate cancer to identify themes and develop a m…

This study tests a web-based education tool called HOPE-Genomics that helps cancer patients learn about their genetic test results. About 465 adults with certain cancers (breast, lung, colorectal, and others) will use the tool to see if it improves their understanding of genomics…

This study looks at whether a special PET scan (using Posluma) on the RefleXion X1 machine can spot prostate cancer tumors as well as the standard PET scan. About 20 adults with prostate cancer will get both scans on the same day. The goal is to see if the new scanner can guide r…

This study collects tissue and blood samples from 2,400 people with early-onset breast, colon, kidney, liver, multiple myeloma, or prostate cancer. Researchers will analyze the samples to find genetic changes that may cause cancer at a young age, especially in racially and ethnic…

This study looks at whether a web-based virtual genetics board helps doctors and other healthcare providers discuss prostate cancer genetics, treatment, and screening. About 118 providers from different settings will give feedback through interviews and surveys. The goal is to un…

This study looks at whether early MRI scans can show if a prostate tumor is responding to a precise type of radiation therapy (SBRT). Researchers will compare MRI changes with PSA levels in 28 men with intermediate- to high-risk localized prostate cancer. The goal is to better un…

This study looks at tiny particles called extracellular vesicles that come from prostate cancer cells. Researchers want to see if levels of these particles in blood and urine change after surgery to remove the prostate. The goal is to learn if these particles can help doctors und…

This study follows 2,500 prostate cancer survivors who had surgery at City of Hope at least one year ago and have no signs of cancer returning. Researchers will track quality of life, sexual health, and long-term complications using surveys and medical records. The goal is to bet…

This study looks at how hormone therapy (anti-androgen treatment) for prostate cancer affects the heart. Researchers will use heart MRIs to measure changes in heart function and muscle in 23 men before and after 4-7 months of treatment. The goal is to better understand the heart …