PROSTATE CARCINOMA

This study is testing a procedure called prostatic artery embolization (PAE) in men with early-stage prostate cancer who have bothersome urinary symptoms and are planning to get radiation therapy. Doctors inject tiny particles to block blood flow to the prostate, aiming to shrink…

This study is testing whether a concentrated green tea extract can help prevent low-risk prostate cancer from getting worse. It involves 360 men who are on active surveillance, meaning they are monitoring their cancer instead of treating it right away. Participants will take eith…

This is a first-in-human study to find a safe dose and see how the body processes a new oral drug called ATV-1601. It is being tested in adults with advanced solid tumors, including certain breast cancers, that have a specific genetic change called an AKT1 E17K mutation. The main…

This study aims to see if MRI scans taken 6-9 months after precise radiation treatment can show how well prostate cancer tumors are responding. Researchers will compare these scan results with standard blood tests (PSA) in 28 men with intermediate to high-risk prostate cancer. Th…

This study is testing if adding the drug olaparib after standard chemotherapy helps control a fast-growing, hard-to-treat form of prostate cancer. About 96 men with advanced, aggressive prostate cancer that has spread will receive chemotherapy, then some will receive olaparib pil…

This study is testing whether a combination of tools can help cancer survivors living in rural areas better manage their health after treatment ends. Participants create their own survivorship care plan and some receive a phone-based education session. The goal is to see if this …

This study is for men with high-risk prostate cancer who have had surgery to remove the prostate. It tests whether adding a new drug called darolutamide to standard hormone-blocking therapy is better at preventing the cancer from spreading to other parts of the body. The goal is …

This large national trial is testing whether choosing cancer drugs based on the specific genetic changes found in a patient's tumor is more effective than standard approaches. It is for adults with advanced solid tumors, lymphoma, or multiple myeloma that have progressed after at…

This study is testing a new type of 3D MRI scan for men with prostate cancer. The goal is to see if this new scan can create clear pictures of the prostate without requiring an uncomfortable rectal coil during the procedure. Researchers will compare the image quality of the new 3…

This study is testing whether a special type of MRI scan can help doctors more accurately determine how aggressive a man's prostate cancer is before he has surgery. The goal is to see if these detailed images, combined with other test results, can create a better prediction model…

This study is testing a new way to find prostate cancer in men whose previous biopsy results were unclear or negative. Researchers are using a special radioactive tracer that sticks to prostate cancer cells, which shows up on a PET/CT scan. This scan then guides the doctor's biop…

This study aimed to test a new type of imaging scan to see if it could better identify aggressive prostate cancer. It planned to compare a special PET/MRI scan to a standard MRI scan in men with elevated PSA levels who were scheduled for a biopsy. The goal was to improve the accu…

This study is testing a new type of imaging machine for men with prostate cancer. Researchers want to see if the pictures it takes are as good as the current standard scan. If successful, this machine could allow doctors to plan a patient's radiation therapy using the same scan, …

This study is testing whether a special type of ultrasound can accurately find prostate cancer. Men scheduled for prostate removal surgery receive a safe, short-lived contrast agent and then have an ultrasound scan. Researchers will compare the ultrasound images to the actual pro…

This study is testing whether a new device called the OmnEcoil system can safely combine two prostate cancer detection steps into one procedure. Currently, men with suspicious prostate findings typically get an MRI scan first, then return later for a separate biopsy. This device …

This study is testing if a special full-body MRI scan is better than the standard combination of bone and CT scans at finding out if high-risk prostate cancer has spread to the bones or lymph nodes. Men with high-risk prostate cancer will receive both the new MRI scan and the sta…

This study is testing if a modified type of MRI scan can create better images of prostate cancer than the standard MRI. The goal is to help doctors see the cancer more clearly before a patient has surgery to remove the prostate. Men with confirmed prostate cancer who are schedule…

This study is testing whether combining a stimulant medication (methylphenidate) with a structured exercise program works better than exercise alone to reduce severe, persistent fatigue in men with prostate cancer. It involves about 200 patients who are starting radiation and hor…

This study compares two ways to prepare for prostate cancer radiation therapy: coming with a full bladder or an empty bladder. The standard method requires a full bladder, but this can be difficult for patients to maintain and may cause stress. Researchers want to see if using an…

This study is testing a web-based virtual meeting tool designed to help healthcare providers discuss prostate cancer genetics cases. Doctors and other providers use the tool to talk about genetic testing, personalized treatment options, and screening recommendations. Researchers …

This study aims to understand how immigration experiences affect prostate cancer care decisions and survivorship for men from Sub-Saharan Africa and the Caribbean. Researchers will interview 80 immigrant men who have been diagnosed with prostate cancer to learn about their health…

This small study aims to understand how hormone therapy for prostate cancer affects heart function and muscle health. Researchers will use special heart scans and muscle tests on 23 patients before they start treatment and again 4-7 months later. The goal is to gather information…

This study aims to understand why certain cancers develop at younger ages in people from different racial and ethnic backgrounds. Researchers will collect tumor tissue and blood samples from 2,400 patients during their regular cancer surgeries. By analyzing these samples, they ho…

This study is testing a web-based education tool called HOPE-Genomics to see if it helps cancer patients better understand their personal genetic test results and general cancer genomics. Researchers are comparing the tool's effectiveness against standard education methods in abo…

This study aims to understand if tiny particles released by prostate cancer cells, found in blood and urine, change after surgery and if they relate to standard blood test results. Researchers will collect samples from about 100 men with prostate cancer before and after their sur…

This study tracks the long-term health of prostate cancer survivors who had surgery at least one year ago. Researchers follow 2500 men to understand their quality of life, potential complications, and overall health after treatment. The information gathered will help improve futu…

This study aims to understand how inherited gene mutations affect prostate cancer risk and treatment. Researchers are enrolling 1,360 men with prostate cancer and their family members to collect saliva samples and health information. The goal is to identify patterns that could le…