PROSTATE CARCINOMA

This study is for people with a type of advanced prostate cancer that has stopped responding to standard treatments. It compares the usual fixed schedule of 6 doses of Lu-PSMA therapy given every 6 weeks to a flexible schedule that allows up to 12 doses with planned breaks based …

This trial tests a procedure called TULSA that uses MRI-guided sound waves to heat and destroy prostate cancer cells. It is for men aged 45-80 with low to intermediate grade prostate cancer that hasn't spread. The goal is to see if this approach can control the cancer while helpi…

This study is for men with high-risk prostate cancer that hasn't spread far. It tests whether adding the drug niraparib to standard hormone therapy after radiation can keep the cancer from coming back longer. About 200 participants will receive either hormone therapy alone or hor…

This study looks at whether time-restricted eating (intermittent fasting) or GLP-1 medications (semaglutide and tirzepatide) can better protect the heart and metabolism of prostate cancer patients on hormone therapy compared to a standard heart-healthy diet. About 60 men aged 30-…

This study tests whether combining two drugs—pembrolizumab (an immunotherapy) and 177Lu-PSMA-617 (a targeted radiation therapy)—can slow or stop the growth of advanced prostate cancer that has spread and no longer responds to hormone therapy. About 48 men with this type of cancer…

This study tests whether a special PET/CT scan using a radioactive tracer (flotufolastat F 18) can better guide prostate biopsies than standard MRI. About 30 men with suspicious MRI findings will get both types of scans before biopsy. The goal is to see if the new method finds mo…

This study tests whether a special PET/CT scan using flotufolastat F 18 can find leftover or returning prostate cancer after focal therapy. About 81 men who had focal treatment 6-36 months ago will get the scan. If it works, it could offer a less invasive way to check for cancer …

This study is testing a new way to detect prostate cancer by looking at cells in urine using a special imaging method. Researchers will collect urine samples from 675 men aged 50-75, some with prostate cancer and some without, to see how accurate the test is. The goal is to find …

This study tests whether an artificial intelligence (AI) system can analyze prostate MRI scans as accurately as a radiologist to detect prostate cancer. About 130 men who need a prostate biopsy will have their MRI read by both the AI and a radiologist. The goal is to see if the A…

This study tests a new technique called 'Spot Delete' in proton therapy for low- and intermediate-risk prostate cancer. The goal is to reduce side effects like diarrhea, rectal bleeding, and bladder problems by preventing proton beams from stopping in the bowel and rectum. The st…

This study looks at whether sucking on popsicles during chemotherapy can reduce taste changes in prostate cancer patients. Taste changes are a common side effect of taxane chemo, and cooling the mouth may help by reducing blood flow to taste buds. The study will enroll 60 patient…

This study tests an internet-based program that combines weight loss and resistance training to help men who have had prostate cancer and hormone therapy. The goal is to reduce obesity and frailty, which can improve quality of life and lower the risk of falls. About 250 men will …

This study tests whether a computer program called RapidPlan can create radiation treatment plans for prostate cancer that are as good as or better than plans made by human experts. The goal is to see if the computer's plans lead to fewer serious side effects. About 108 men with …

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are receiving hormone therapy (ADT) combined with other treatments. About 210 men will either start light therapy right away or wait a fe…

This study tests whether adding social support to group exercise helps older men (65+) with prostate cancer feel less lonely and improve their mental and physical health. 150 men will be assigned to one of three 6-month programs: socially-enhanced group exercise, standard group e…

This study tests whether light therapy and occupational therapy can help reduce cancer-related fatigue in people with bladder, kidney, or prostate cancer. About 224 participants who are on active treatment will be assigned to receive light therapy, occupational therapy, both, or …

This study tests if fezolinetant, a drug used for hot flashes in women, can reduce hot flashes in men with prostate cancer who are on hormone therapy. About 60 men will take either the drug or a placebo daily for 4 weeks. Researchers will track hot flash frequency, severity, and …

This study at Mayo Clinic tests new AI image-processing methods (AirRecon DL and Sonic DL) to see if they can make MRI scans faster and clearer for detecting pelvic abnormalities like prostate or endometrial issues. About 60 adults will get standard and AI-enhanced scans, which r…

This study looks at why African American men with prostate cancer often miss out on genetic testing and whether a community-based health coach can help. About 72 men will receive tailored education to improve their knowledge and decision-making. The goal is to learn how to make g…

This study is testing a virtual robot assistant (ViRA) to help Black men who have just been diagnosed with prostate cancer. The goal is to see if men find the tool helpful and easy to use for getting support and information. About 53 participants will try the app and give feedbac…

This study sets up Community Living Labs at American Legion Posts to help Black men learn about and access prostate cancer screening and services. Community health workers will connect men with doctors and resources. The goal is to see if this approach improves health knowledge a…

This study tests an online platform for people with lung, colorectal, breast, or prostate cancer to track medication side effects and concerns at home. About 80 participants will use the tool and report on its ease of use and how it affects their health. The goal is to see if sel…

This study tests whether special breathing exercises can improve brain and mental health in people with multiple sclerosis or cancer, and their caregivers. Researchers will use MRI scans to see how breathing affects oxygen flow in the brain. The goal is to understand the connecti…

This early study tests a radioactive imaging agent called 99mTc-PSMA-I&S in 30 men with prostate cancer who are scheduled for lymph node removal surgery. The goal is to see how the agent spreads in the body and whether it can help surgeons detect cancer that has spread to lymph n…

This study looks for better ways to find aggressive prostate cancer early in people who have a genetic risk. Researchers will collect blood, urine, and tissue samples from 450 participants aged 40 and older with certain gene changes. The goal is to improve screening and treatment…

This study is testing new blood tests that look for signs of many different cancers at the same time. Researchers want to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will be split into three groups:…

This study is gathering blood, urine, tissue samples, and health information from 300 men with advanced prostate cancer. The goal is to create a research resource that scientists can use to better understand the disease and find ways to improve future treatments. Participants wil…