PROSTATE CARCINOMA

This study is testing a new combination treatment for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. It combines a targeted radiation drug that seeks out and destroys prostate cancer cells with an immunotherapy drug de…

This study is testing if adding a drug called niraparib to standard hormone therapy after radiation treatment works better at controlling high-risk prostate cancer that is still in the prostate area or nearby lymph nodes. It will enroll about 200 men. The goal is to see if this c…

This study is for men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy and chemotherapy. It compares the current standard treatment schedule (6 fixed doses) to a new, flexible schedule (up to 12 doses with breaks). The goal is to se…

This study compares two approaches to protect heart and metabolic health in prostate cancer patients undergoing hormone therapy. Researchers will test whether time-restricted eating (a form of intermittent fasting) or specific weight-loss medications work better than standard hea…

This study is testing whether a computer program called RapidPlan can create radiation treatment plans for prostate cancer that are as safe and effective as plans made by human experts. It will enroll 108 men to see if the AI-generated plans cause similar or fewer serious side ef…

This study is testing a new technique called 'Spot Delete' during proton beam therapy for prostate cancer. Researchers want to see if carefully controlling where the proton beams stop in the body can reduce common and painful side effects like diarrhea, rectal bleeding, and urina…

This study is testing whether a minimally invasive procedure using focused ultrasound waves can safely destroy prostate cancer tumors. The treatment, guided by MRI imaging, aims to control cancer while helping men avoid surgery and maintain their urinary and sexual function. Rese…

This study is testing two new blood tests designed to screen for 11 different cancers at the same time. It will enroll 24,000 healthy adults aged 45-75 to see how well these tests work for early detection and to understand how people and their doctors respond to the results. The …

This study is testing a new urine test designed to detect prostate cancer cells. Researchers will analyze urine samples from about 675 men, including those with and without cancer, to see if the test can accurately identify the disease. The goal is to develop a less invasive way …

This study is testing whether an artificial intelligence (AI) system can be as good as experienced radiologists at finding aggressive prostate cancer on MRI scans. It will compare the AI's analysis to the standard method where a doctor reviews the images. The goal is to see if AI…

This study aims to find better ways to detect prostate cancer early in people who have a genetic risk for aggressive disease. Researchers will collect blood, urine, and tissue samples from 450 participants over three years to analyze and improve current screening tests. The goal …

This early study is testing a new radioactive tracer called 99mTc-PSMA-I&S. It is designed to help surgeons better see and remove prostate cancer that has spread to lymph nodes during an operation. The study will enroll 30 men with prostate cancer who are already scheduled for ly…

This study is testing new AI-powered image processing techniques to see if they can make MRI scans for pelvic cancers faster and produce clearer pictures. It will involve 60 adults who are already scheduled for scans to check for prostate or endometrial cancer. The goal is to see…

This study is testing a new type of imaging scan to see if it can accurately find prostate cancer that remains or returns after a man has had a targeted, less-invasive treatment. Men who had a focal therapy (like laser or ultrasound) for prostate cancer within the past 6 months t…

This study is testing whether a new type of PET scan, which uses a radioactive tracer to highlight prostate cancer cells, can better guide doctors when taking biopsy samples from the prostate. Researchers will compare this new method to the current standard of using MRI scans for…

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing if two non-drug approaches can help reduce the severe tiredness (fatigue) that often comes with cancer and its treatment. Researchers are enrolling 224 adults with bladder, kidney, or prostate cancer who are experiencing significant fatigue. Participants wil…

This study is testing if sucking on popsicles before, during, and after a specific type of chemotherapy can help reduce taste changes, a common and bothersome side effect. It will involve 60 men with prostate cancer who are about to start their first round of taxane chemotherapy.…

This study is testing whether wearing bright white light therapy glasses can help reduce severe tiredness and low mood in men with advanced prostate cancer who are receiving powerful hormone-based treatments. The main goal is to see if starting the light glasses right away is bet…

This study is testing whether a daily routine of guided breathing exercises can improve brain health and mental well-being. It is enrolling patients with multiple sclerosis or certain cancers, as well as their caregivers, to see if the practice reduces symptoms like fatigue, anxi…

This study is testing whether a medication called fezolinetant can safely reduce the frequency and severity of hot flashes in men with prostate cancer who are undergoing hormone-blocking therapy. Researchers will compare the drug to a placebo in 60 participants over 4 weeks to se…

This study aims to collect health information and biological samples from 300 men with advanced prostate cancer. Researchers will gather blood, urine, and data on treatments and quality of life to create a detailed research database. The goal is to help scientists learn more abou…

This study is testing whether a virtual robot assistant can help Black men newly diagnosed with prostate cancer. The app provides support with healthcare navigation, emotional needs, and practical resources. Researchers want to see if patients find the virtual assistant helpful a…

This study is testing whether an online self-monitoring platform is a useful tool for cancer patients. It aims to help patients track side effects and concerns about their oral cancer medications while they are at home. The research will see if using the app improves how patients…

This study is testing a new community-based program designed to improve prostate health education and access to services for Black men. It will set up 'Community Living Labs' at local American Legion posts in Florida, using trained community health workers to connect men with inf…

This study aims to understand and overcome barriers to genetic testing for Black men with advanced prostate cancer. Researchers are testing whether a community-based health coach, providing culturally tailored education, can improve knowledge and access to testing. The goal is to…