New PET-MRI tracer could sharpen prostate cancer biopsy accuracy
NCT ID NCT06865768
First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time
Summary
This trial tests whether combining a radioactive tracer (18F-rhPSMA-7.3) with PET and multiparametric MRI can better identify clinically significant prostate cancer than MRI alone. Men suspected of having prostate cancer will receive the tracer and undergo imaging before a targeted biopsy. The goal is to see if the tracer's activity in suspicious areas improves the detection of aggressive tumors, potentially making biopsies more accurate.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a radioactive tracer called 18F-rhPSMA-7.3 (flotufolastat F-18) given intravenously, plus magnetic resonance imaging (MRI)
- What this could lead to
- If successful, this imaging method could help doctors more accurately identify aggressive prostate cancers during biopsy, reducing unnecessary procedures and improving treatment decisions.
- What could go wrong
- This is a phase II trial with only 90 participants, so results may not apply to all men. The technique may not significantly outperform standard MRI, and there are small risks from radiation exposure and MRI contraindications.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Emory University Hospital
RECRUITINGAtlanta, Georgia, 30322, United States
Contact
Contact Email: •••••@•••••
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