POSTOPERATIVE DELIRIUM

This study tests whether daridorexant, a sleep medication, can prevent delirium (sudden confusion) after heart surgery in adults aged 60 and older. About 80 participants will receive either the drug or a placebo for three nights after surgery. Researchers will track delirium symp…

This study tests whether doing simple, home-based brain exercises for a few weeks before heart surgery can help prevent postoperative delirium (sudden confusion) and long-term memory problems. Researchers will enroll 100 adults scheduled for elective heart surgery. Half will do t…

This study tests whether relaxation techniques—like virtual reality and special sound beats—given before heart surgery can lower stress and prevent mental problems such as confusion or memory loss after the operation. About 125 adults having elective heart surgery will be randoml…

This study tests whether a smartphone app that helps improve sleep, along with a wearable activity tracker, can support brain health in adults aged 65 and older who are having hip or knee replacement surgery. About 50 participants will use the app and tracker before and after sur…

This study looks at how two types of anesthesia — inhaled gas or IV drugs — affect thinking and recovery after sleeve gastrectomy (weight-loss surgery). About 60 adults having this surgery will be randomly assigned to one method. Researchers will measure how quickly they wake up …

This study looks at 100,000 adults having surgery to find out if one type of anesthesia (propofol or sevoflurane) is better at preventing postoperative delirium—a state of confusion that can happen after surgery. Researchers will track who develops delirium in the first 5 days af…

This study is looking for a way to predict which older adults with diabetes might become confused after surgery. Researchers will measure specific proteins in the blood before surgery and see if they are linked to confusion in the days after. The goal is to better understand and …

This study watches 270 older adults (65+) having non-cardiac surgery to see how often they become confused or delirious afterward. Researchers will track risk factors like age, frailty, and health conditions. No treatments are tested—the goal is simply to learn more about who get…

This study watches brain activity and blood oxygen levels in 100 adults aged 60 and older during major non-cardiac surgery. The goal is to find the best blood pressure range for each person to protect brain health and reduce confusion after surgery. Participants wear stickers on …

This study looks at whether a score based on routine blood tests (the Naples Prognostic Score) can predict postoperative delirium—sudden confusion—in older adults after hip fracture surgery. Researchers will enroll 168 patients aged 60 and older and check for delirium daily using…

This study looks at 500 adults having heart surgery to see if keeping blood pressure within a personalized range for each patient's brain can lower the risk of confusion, stroke, or memory loss after surgery. Researchers will use special monitors to track brain blood flow and adj…

This study looks at 1500 adults having planned heart surgery to understand why some become confused or delirious afterward. Researchers will track patients before and after surgery to find early warning signs and see how delirium affects recovery over time. The goal is to improve…

This study looks at whether feeling distressed before surgery increases the risk of confusion (delirium), pain, and longer hospital stays in older adults having major orthopedic surgery. Researchers will measure distress levels before surgery and track outcomes in 150 patients ag…

This study is looking at whether simple blood tests can help predict which children might become confused or agitated after waking up from anesthesia for circumcision. Researchers will check inflammation levels in the blood before surgery and watch for signs of delirium in the re…