POSTOPERATIVE DELIRIUM

This study tests whether electroacupuncture (a gentle electrical stimulation on acupuncture points) can prevent postoperative delirium—sudden confusion and disorientation—in older adults having total knee replacement. About 1,460 participants aged 65-90 will receive either electr…

This study looks at whether using a drug combination without opioids during anesthesia can lower the chance of confusion (delirium) after surgery in people 65 and older having gastrointestinal surgery. About 174 participants will be randomly assigned to receive either opioid-free…

This study tests whether taking creatine, a common supplement used for muscle strength, can help protect thinking and memory in older adults after surgery. About 80 people having planned surgery will take creatine or a placebo. Researchers will check their brain function before a…

This study looks at whether giving older patients (60+) a common pain reliever (paracetamol and mannitol injection) after non-cardiac surgery can lower their risk of postoperative delirium—a state of sudden confusion. About 1,092 participants will be randomly assigned to receive …

This study tests whether a sedative called remimazolam can lower the risk of postoperative delirium (sudden confusion) in patients 65 and older having laparoscopic stomach cancer surgery. 170 participants will be randomly assigned to receive either remimazolam or standard anesthe…

This study looks at whether giving ibuprofen during and right after lung surgery can help keep the brain well-oxygenated and lower the risk of confusion or memory problems afterward. About 54 adults having a type of keyhole lung surgery will be split into two groups: one gets ibu…

This study looks at whether giving a drug called flumazenil after hip replacement surgery can prevent confusion and help people think more clearly. About 150 adults having hip surgery will get either flumazenil or a placebo. Researchers will check their thinking and memory 24 hou…

This study tests three different doses of esketamine (a type of anesthetic) to see if it can prevent confusion and memory problems in older adults after major non-cardiac surgery. 120 patients aged 65-90 will receive one of three doses during and after surgery. The goal is to fin…

This study looks at whether a simple blood sugar measurement, called the stress hyperglycemia ratio, can help predict who might develop confusion (delirium) after surgery. Researchers will review records from 15,000 adults who had non-brain, non-heart surgeries. The goal is to fi…

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This study will measure certain brain chemicals in 200 children aged 1-3 who are having hernia surgery. The goal is to see if changes in these chemicals can predict which children might become confused or have memory problems after surgery. Researchers will also compare two diffe…

This study looks at whether the way you sleep before heart surgery is connected to problems like confusion (delirium) or kidney damage after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to find patterns that …

This study looks at whether measuring the optic nerve sheath (the covering of the nerve at the back of the eye) with ultrasound can help predict delirium—sudden confusion or agitation—after heart surgery. Researchers will include 300 adults having heart surgery with a heart-lung …

This study looks at whether measuring brain energy use before surgery can help predict postoperative delirium (sudden confusion) in older adults with type 2 diabetes. Researchers will scan the brain's memory center (hippocampus) in 154 patients aged 65+ scheduled for liver tumor …

This study looks at whether using brain-wave (EEG) monitoring to guide pain medication during surgery can reduce the risk of delirium—sudden confusion—after the operation. Researchers will enroll 600 adults aged 60 and older having non-cardiac surgery. The goal is to see if adjus…

This study looks at whether older adults with mild memory issues are more likely to become confused after planned hip replacement surgery. Researchers will test memory before surgery and watch for confusion in the first three days after. The goal is to see if a quick memory test …