NSCLC

This early-stage trial is testing a new drug called TB511, both by itself and in combination with the immunotherapy drug pembrolizumab (Keytruda). It aims to find a safe dose and see if it can shrink tumors in people with advanced solid cancers, including lung, prostate, colorect…

This study is testing whether taking Iruplinalkib tablets after surgery can help prevent early-stage lung cancer from returning. The trial will involve 28 patients who have had surgery for a specific genetic type of lung cancer and have certain risk factors. Researchers will trac…

This study is testing whether combining an older chemotherapy drug (gemcitabine) with a newer two-target drug (ivonescimab) can help control advanced non-small cell lung cancer that has gotten worse despite standard treatment. It will involve about 47 adults whose cancer has prog…

This study is testing if adding an over-the-counter allergy medication (diphenhydramine) to standard chemotherapy and immunotherapy improves results for people with operable non-small cell lung cancer. About 120 participants will receive the drug combination before surgery and th…

This study is testing whether a new targeted drug called limertinib works better when combined with radiation therapy for people with a specific type of lung cancer (EGFR-mutant) that has spread to the brain. It will involve about 45 adults who have not yet received any treatment…

This study is testing whether a new two-in-one immunotherapy drug (QL1706) works better when given alongside a precise, high-dose form of radiation (SBRT) for people with early-stage non-small cell lung cancer. The main goal is to see if this combination can help control the canc…

This study is testing if adding a new drug called SYS6010 to a standard lung cancer drug (osimertinib) works better for controlling advanced non-small cell lung cancer with specific genetic changes (EGFR mutations). About 450 adults who haven't yet received treatment for their ad…

This study is testing whether a combination of two drugs, SHR-A1811 and adebelimumab, can shrink tumors before surgery in people with early-stage, operable lung cancer that has a specific genetic marker called HER2. The goal is to see if this pre-surgery treatment helps eliminate…

This study tests a chemotherapy-free combination treatment given before surgery for certain types of operable lung cancer. It aims to shrink tumors using targeted radiation, immunotherapy, and a drug that blocks tumor blood vessels, hoping to improve surgical outcomes and reduce …

This study is testing whether adding a targeted drug called Bozitinib to standard chemotherapy helps shrink tumors before surgery for people with a specific genetic change (MET-altered) in their stage IIA-IIIC non-small cell lung cancer. The main goal is to see if this combinatio…

This study is testing whether a drug called Vebreltinib can shrink tumors in patients with a specific genetic type of non-small cell lung cancer before they have surgery. About 30 eligible patients will take the drug for 8 weeks prior to their planned operation. The main goal is …

This study is testing a new drug called GFH276 in adults with advanced cancers that have a specific genetic change called a RAS mutation. The main goals are to find a safe dose and see if the drug can shrink tumors in cancers like pancreatic, lung, and colorectal cancer. It is an…

This study is testing whether a three-part treatment given before surgery can better eliminate cancer cells in patients with operable non-small cell lung cancer. The treatment combines a short, precise course of radiation (SBRT) with two immunotherapy drugs and standard chemother…

This study is testing whether a personalized exercise program is practical and acceptable for people with stage II-III lung cancer. It will involve about 20 participants who will follow the exercise plan before, during, and after their cancer treatment. The main goal is to see if…

This study is testing whether a brief psychological support program before lung cancer surgery can help reduce patients' anxiety and depression. It will involve 138 adults scheduled for surgery, comparing those who receive four weekly therapy sessions to those who do not. The mai…

This study aims to see how a non-invasive treatment called Tumor Treating Fields (TTFields) affects lung cancer cells before surgery. TTFields uses low-intensity electrical fields. The study will enroll 18 patients with early-stage lung cancer to check the safety of the treatment…

This study looks back at 300 patients with a type of lung cancer who received immunotherapy before surgery but still had cancer cells left after the operation. Researchers will analyze the leftover tumor tissue using advanced genetic testing to search for hidden genetic reasons w…