NON-HODGKIN LYMPHOMA

This was a first-in-human study to test the safety and find the right dose of a new oral drug, JNJ-64619178, for people with advanced cancers that have not responded to other treatments. It involved 114 adults with specific advanced solid tumors, non-Hodgkin lymphoma, or a type o…

This early-stage study tested the safety and initial effectiveness of a new drug called odronextamab in 200 adults with advanced non-Hodgkin lymphoma or chronic lymphocytic leukemia. The drug is designed to attach to cancer cells and the immune system to help the body fight the c…

This study tested whether adding a drug called anakinra to a powerful cell therapy (CAR-T) could reduce severe brain-related side effects in patients with lymphoma that has returned or resisted treatment. The main goal was to see if this combination made the CAR-T treatment safer…

This early-phase study tested a new gene therapy approach for patients whose non-Hodgkin lymphoma or chronic lymphocytic leukemia had returned or didn't respond to standard treatments. Researchers modified patients' own immune T-cells in the lab to better recognize and attack the…

This study tested whether adding targeted radiation could help patients with aggressive lymphoma who didn't fully respond to CAR-T cell therapy. Researchers gave radiation to the remaining cancer spots in 14 patients about a month after their CAR-T treatment. They wanted to see i…

This study tested whether giving vitamin D supplements to patients with newly diagnosed lymphoma or leukemia who have low vitamin D levels could help control their cancer. Researchers compared high-dose and low-dose vitamin D against no treatment to see if it improved how long pa…

This study tested a computer tool that automatically shows a cancer survivor's heart health risks using their existing medical records. The goal was to see if this tool helped survivors and their cancer doctors have better conversations about heart health, leading to more referra…

This early-stage study aimed to find a safe dose of a new drug combination (BMS-986345 plus duvelisib) for patients with advanced blood cancers like lymphoma and leukemia. It involved 14 adults whose cancers had progressed after other treatments. The main goal was to check for si…

This large, completed Phase 3 trial tested whether a personalized cell therapy called tisagenlecleucel (a type of CAR-T) works better than standard chemotherapy and stem cell transplant for adults with aggressive B-cell non-Hodgkin lymphoma that returned or didn't respond to init…

This early-stage study tested the safety and effectiveness of a new three-drug combination (VVIP) for adults with aggressive non-Hodgkin lymphomas that had returned or not responded to prior treatments. The goal was to find the highest safe dose and see if the treatment could mak…

This small pilot study tested whether an 8-week home exercise program delivered via video calls is practical and helpful for lymphoma survivors. The goal was to see if regular, guided workouts could improve heart health and reduce future cardiovascular risks in people who had fin…

This study aimed to find the best strategy for finding bone marrow transplant donors for patients with blood cancers and disorders. It compared whether patients should first search for a perfectly matched unrelated donor or go directly to alternative donors like family members or…

This was the first-ever study in people of an experimental drug called WTX-330, designed to treat advanced cancers that have spread or stopped responding to standard treatments. The small trial enrolled 25 adults with advanced solid tumors or lymphoma to find a safe dose and see …

This study tested a two-step, lower-intensity stem cell transplant for patients with high-risk blood cancers like leukemia and lymphoma. The goal was to use milder chemotherapy and radiation before the transplant to reduce side effects while still allowing the donor's immune cell…