NON HODGKIN LYMPHOMA

This early-stage study tested a new drug called odronextamab (REGN1979) in 200 people with B-cell blood cancers like non-Hodgkin lymphoma and chronic lymphocytic leukemia that had stopped responding to prior treatments. The goal was to check the drug's safety and find the right d…

This study tested whether giving focused radiation to leftover cancer spots can help non-Hodgkin lymphoma patients who didn't fully respond to CAR-T cell therapy. Fourteen adults with aggressive lymphoma received radiation to those spots. The goal was to see if it was safe and co…

This phase III trial tested whether the CAR-T cell therapy tisagenlecleucel works better than standard treatments for adults with aggressive B-cell non-Hodgkin lymphoma that came back after initial therapy. About 330 participants were randomly assigned to receive either the CAR-T…

This study tested whether adding the drug anakinra to standard CAR-T cell therapy could reduce serious brain side effects in people with relapsed or refractory non-Hodgkin lymphoma. Fifteen participants received the combination. The goal was to see if anakinra could lower the rat…

This study tested an experimental therapy called AB-101, made from donor natural killer (NK) cells, in 45 people with B-cell non-Hodgkin lymphoma that returned or didn't respond to prior treatments. The goal was to see if AB-101 is safe and can shrink tumors when given alone or c…

This early-phase study tested a new drug called WTX-330 in 25 adults with advanced solid tumors or lymphoma that had stopped responding to standard treatments. The main goals were to check safety, find the right dose, and see if the drug could shrink tumors. The study is now comp…

This study tested a two-step stem cell transplant for 62 people with high-risk blood cancers like leukemia and lymphoma. First, patients got low-dose chemotherapy and radiation to prepare the body. Then, they received donor immune cells followed by a stem cell transplant. The goa…

This early-phase study tested a new approach for people with advanced B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia (CLL) that had returned or not responded to standard treatments. Researchers took patients' own immune cells (T cells) and added a special receptor (a…

This early-stage study tested a new drug called JNJ-64619178 in 114 adults with advanced cancers (like lymphoma, solid tumors, or myelodysplastic syndromes) that had not responded to other treatments. The main goal was to find the safest dose and check for side effects. The drug …

This early-phase study tested a new drug combination (duvelisib plus BMS-986345) in 14 people with blood cancers like lymphoma, myeloma, or leukemia. The main goal was to find a safe dose and check for side effects. Researchers also looked at how well the cancer responded after 3…

This study looked at whether giving vitamin D supplements to people with newly diagnosed non-Hodgkin lymphoma or chronic lymphocytic leukemia who have low vitamin D levels could improve their outcomes. About 197 participants received either a low or high dose of vitamin D alongsi…

This study tested a new combination of three drugs (VIP152, venetoclax, and prednisone) in 8 adults with aggressive blood cancers like diffuse large B-cell lymphoma that had returned or not responded to prior treatments. The goal was to find a safe dose and see if the combination…

This small pilot study tested whether an 8-week home exercise program guided by a trainer over video calls is practical and helpful for lymphoma survivors. The goal was to see if this approach could improve heart health in survivors who face a higher risk of cardiovascular proble…

This study looked at 1,753 patients needing a bone marrow transplant for blood cancers or other serious blood disorders. It compared two approaches: first searching for a matched unrelated donor, or going straight to an alternative donor (like a half-matched family member). The g…

This study tested a computer tool that helps doctors and cancer survivors discuss heart health during follow-up visits. 645 survivors of breast, prostate, colorectal, endometrial, or lymphoma cancers took part. The tool aimed to increase conversations about heart risks and referr…

This study tested a personalized geriatric optimization plan (GO!) in 30 patients aged 60 and older who were getting a stem cell transplant for blood cancers or bone marrow failure. The plan included tailored changes to diet, sleep, activity, and medications. The goal was to see …

This study aimed to find blood-based markers that could predict how well cancer immunotherapy works. Researchers collected blood samples from 135 adults with advanced lung cancer, lymphoma, or urologic cancers before and during treatment. They measured immune-suppressing cells an…