NASOPHARYNGEAL CARCINOMA

This study tests whether adding a new drug combination (gemcitabine, docetaxel, and toripalimab) before standard radiation can safely and effectively cure a specific type of throat cancer (nasopharyngeal carcinoma) linked to the Epstein-Barr virus. About 24 adults with advanced b…

This phase 3 trial tests whether adding stereotactic body radiotherapy (precise radiation) to the immunotherapy drug camrelizumab helps control cancer better than camrelizumab alone in people with nasopharyngeal carcinoma that has spread to a few spots (oligometastatic). The stud…

This early-phase study tests two types of specially engineered immune cells (CAR-T and TCR-T) that target the Epstein-Barr virus (EBV) in patients whose nasopharyngeal cancer has come back or not responded to standard treatments. About 24 adults aged 18-75 with EBV-positive tumor…

This study tests whether adding the drug envafolimab to standard chemoradiation and another drug (endostatin) can better shrink tumors in people with advanced nasopharyngeal cancer. About 30 adults aged 18-65 with stage III-IVA disease will receive the combination. The goal is to…

This study tests a new drug called Becotatug Vedotin in children aged 2 to 18 with certain cancers (like head and neck, brain, or kidney tumors) that have come back or spread. The drug targets a protein called EGFR found on many cancer cells. The main goal is to see if the drug i…

This study tests a year-long maintenance treatment with two drugs (tislelizumab and low-dose capecitabine) in 53 adults with high-risk nasopharyngeal cancer who still have detectable virus levels after initial chemotherapy. The goal is to see if this combination can improve the c…

This study tests a new treatment for people whose nasopharyngeal cancer has come back or spread. It combines two types of radiation with immunotherapy and chemotherapy. The goal is to see if this mix can control the cancer longer and with manageable side effects. About 148 adults…

This study looks at whether a carefully planned nutrition program can improve health and treatment results for people with advanced nasopharyngeal cancer who are already malnourished. About 266 adults aged 18 to 65 will be randomly assigned to receive either standard nutrition th…

This study looks at whether a lower dose of radiation, combined with chemotherapy and immunotherapy, can control stage III nasopharyngeal cancer as well as the standard higher dose. About 593 patients whose tumors respond well to initial treatment will be randomly assigned to eit…

This study tests whether adding low-dose radiation and an immunotherapy drug (cadonilimab) to standard chemotherapy can help people with advanced nasopharyngeal cancer live longer without the cancer coming back. About 380 adults aged 18-70 with newly diagnosed, advanced-stage dis…

This study compares a lower dose of radiation (40.2Gy) to the standard dose (49.2Gy) for people with stage II nasopharyngeal cancer that responds well to chemotherapy. All participants also receive immunotherapy. The goal is to see if the lower dose can control the cancer just as…

This study looks at whether giving lower doses of radiation after a good response to initial chemotherapy can control EBV-associated nasopharyngeal cancer as well as standard radiation. About 66 people with stage III or IVA disease will receive either reduced or standard radiatio…

This study tests a combination of two drugs (BL-B01D1 and a PD-1 antibody) in adults with advanced or spreading non-small cell lung cancer, nasopharyngeal cancer, or other solid tumors. The goal is to see if the combo can shrink tumors and control the disease. About 570 participa…

This study tests whether giving radiation only to the specific neck areas where cancer has spread can reduce side effects and improve quality of life for people with nasopharyngeal cancer. About 470 patients will be assigned to either standard or personalized radiation. The goal …

This study is testing a new two-drug combination (BL-B01D1 + SI-B003) for people with advanced non-small cell lung cancer or nasopharyngeal carcinoma that has spread. The main goal is to see if the treatment is safe and if it shrinks tumors. Researchers will enroll about 121 adul…

This study tests a new type of PET scan that targets a protein called CD70, which is found on some cancer cells. The goal is to see if this scan can better detect kidney cancer, lymphoma, and nasopharyngeal cancer compared to standard scans. About 300 adults with known or suspect…