MDS

This early-stage study is testing a new drug called eganelisib, both by itself and combined with an existing chemotherapy drug (cytarabine), in adults whose acute myeloid leukemia (AML) or related blood disorder has returned or not responded to prior treatments. The main goals ar…

This study is testing if adding a precise, targeted form of radiation to the standard treatment before a stem cell transplant can kill more cancer cells in the bone marrow and lower the chance of the disease coming back. It is for adults aged 18-75 with acute leukemia or myelodys…

This early-stage study is testing a new type of treatment called MT-401-OTS, which uses specially prepared immune cells from healthy donors to fight cancer. It is for adults aged 65+ with certain types of relapsed acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) wh…

This study is testing a new cell therapy called BSB-1001 for adults with certain high-risk blood cancers (AML, ALL, or MDS). The goal is to see if giving these specially engineered immune cells after a donor stem cell transplant is safe and can help prevent the cancer from coming…

This study will monitor 1,000 people for 15 years after they received an experimental T-cell therapy for blood cancers like leukemia. The goal is to track long-term safety and see how well the treatment continues to work over time. No new treatment is given in this study; researc…

This study is testing whether combining two drugs, luspatercept and ESA, works better than luspatercept alone for patients with a lower-risk type of bone marrow disorder called MDS. It is for adults whose disease has not improved or has returned after a common first treatment. Th…

This study is testing a new type of CAR T-cell therapy for children and young adults (up to age 21) whose blood cancers have come back or haven't responded to standard treatments. The main goal of this early-phase trial is to find a safe and effective dose. Doctors will first giv…

This early-stage study is testing a new oral drug combination (THU and decitabine) for adults with myelodysplastic syndromes (MDS) that have returned or not responded to prior treatment. The main goals are to check the safety of the drugs and see if they improve health and reduce…

This study is testing whether a two-drug treatment given after a bone marrow transplant can help prevent leukemia and related blood cancers from coming back. It involves children and young adults up to age 39 who have had a transplant for conditions like acute myeloid leukemia (A…

This study is testing whether a stem cell transplant from a matched donor can treat GATA2 deficiency, a rare genetic disorder that causes serious infections and can lead to blood cancers. The transplant aims to replace the patient's faulty bone marrow with healthy donor cells to …

This study is testing a cord blood transplant for children and young adults (up to age 21) with life-threatening blood cancers and disorders who do not have a perfectly matched donor. The main goal is to see how safe the procedure is by measuring the risk of death from the treatm…

This is a first-in-human study to test a new drug called CG009301 in adults with blood cancers that have returned or stopped responding to standard treatments. The main goals are to find a safe dose and see how the body processes the drug. About 45 participants will receive the t…

This study aims to create a simple blood test that could replace painful bone marrow biopsies for diagnosing myelodysplastic syndrome (MDS) and other blood cell deficiencies. Researchers will collect blood samples from 1,500 adults who are already scheduled for bone marrow evalua…

This study is for adults with advanced blood cancers (MDS or AML) who are in palliative care and need regular blood transfusions. It compares two ways to decide when to give a transfusion: the usual method based on a blood count number, versus a new method based on changes in the…

This study aims to discover new genes that cause cancer to run in families, especially those affecting children. Researchers will collect health information, blood, and sometimes leftover tumor samples from families where multiple members have had cancer. The goal is to build a l…

This study is collecting information about how patients with blood cancers and disorders respond to stem cell transplants in the high-altitude Tibetan region. Researchers are enrolling 1000 patients and their donors to track treatment patterns, recovery times, survival rates, and…

This study aims to gather detailed information on many different blood diseases in China, including cancers like leukemia and lymphoma, and conditions like hemophilia. It will follow 2,300 patients to learn how common these diseases are, what treatments patients receive, how well…