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Supercharged donor cells aim to stop leukemia return after transplant

NCT ID NCT07702578

Recruiting now ⭐️ CURE ⭐️ Sponsor: TScan Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 23, 2026 · Updated 5 times

Summary

This study tests a new approach to prevent leukemia from coming back after a stem cell transplant. It uses donor T cells that have been engineered to recognize and attack a specific target (HA-2) on leukemia cells. The trial enrolls adults with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) who are receiving a stem cell transplant from a partially matched donor. Half receive the engineered cells plus standard care, and half receive standard care alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
TSC-101, a T-cell receptor engineered donor T cell therapy targeting HA-2
What this could lead to
If successful, TSC-101 could reduce the risk of leukemia relapse after stem cell transplant, potentially leading to higher cure rates for AML and MDS.
What could go wrong
This is an early-phase trial, so the benefits are not proven. There may be risks like graft-versus-host disease or other immune reactions. The therapy only works for patients with a specific genetic marker (HLA-A*02:01).

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AML MDS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Banner Health - MD Anderson Cancer Center

    NOT_YET_RECRUITING

    Gilbert, Arizona, 85234, United States

    Contact

  • Baylor University Medical Center

    RECRUITING

    Dallas, Texas, 75246, United States

    Contact

  • City of Hope

    RECRUITING

    Duarte, California, 91010, United States

    Contact

  • Columbia University - Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

    Contact

  • Dana-Farber Cancer Institute - Hematology/Oncology

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact

  • Froedtert & Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

    Contact

  • Hackensack University Medical Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

    Contact

  • Honor Health Cancer Transplant Institute

    NOT_YET_RECRUITING

    Scottsdale, Arizona, 85258, United States

    Contact

  • Hospital of the University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact

  • Johns Hopkins University

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact

  • Karmanos Cancer Institute

    RECRUITING

    Detroit, Michigan, 48201, United States

    Contact

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact

  • Memorial Cancer Institute

    RECRUITING

    Hollywood, Florida, 33021, United States

    Contact

  • Moffitt Cancer Institute

    RECRUITING

    Tampa, Florida, 33612, United States

    Contact

  • Mount Sinai Hospital

    RECRUITING

    New York, New York, 10029, United States

    Contact

  • Northside Hospital

    RECRUITING

    Atlanta, Georgia, 30342, United States

    Contact

  • SCRI - Colorado Blood Cancer Institute

    RECRUITING

    Denver, Colorado, 80218, United States

    Contact

  • Sarah Cannon Research Institute - TriStar Bone Marrow Transplant (BMT)

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact

  • St. David's South Austin Medical Center

    RECRUITING

    Austin, Texas, 76704, United States

    Contact

  • Stanford - School of Medicine

    NOT_YET_RECRUITING

    Stanford, California, 94305, United States

    Contact

  • The University of Kansas Cancer Center

    NOT_YET_RECRUITING

    Kansas City, Kansas, 66160, United States

    Contact

  • The University of North Carolina at Chapel Hill

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

    Contact

  • The University of Texas - MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 76704, United States

    Contact

  • University of Chicago

    NOT_YET_RECRUITING

    Chicago, Illinois, 60607, United States

    Contact

  • University of Colorado - Anschutz Cancer Center

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact

  • Yale

    RECRUITING

    New Haven, Connecticut, 06510, United States

    Contact

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