MALARIA

This early-stage trial tested a vaccine called PRIMVAC, designed to prevent malaria during pregnancy. Researchers gave three different doses to 68 healthy adults in France and Burkina Faso, using two different adjuvants to boost immune response. The main goal was to check safety …

This study tested an experimental RNA-based vaccine (BNT165e) to prevent malaria in 163 healthy adults who had never had the disease. The vaccine uses three RNA pieces to train the immune system against the malaria parasite. The main goals were to check safety and see how well th…

This study tested a new malaria vaccine called R21/Matrix-M in 594 children aged 5 to 36 months in Mali. The goal was to check if the vaccine is safe and triggers a strong immune response, both when given alone and alongside routine childhood vaccines. The results will help deter…

This early-stage trial tested a new RNA-based vaccine designed to protect against malaria. Sixty healthy adults received different doses of the vaccine or a placebo to check for safety and to see if it triggers an immune response. The study focused on finding a safe dose and moni…

This study tested the RTS,S/AS01E malaria vaccine in nearly 78,000 young children in Sub-Saharan Africa. Researchers checked the vaccine's safety and how well it prevents malaria. The goal was to see if the vaccine can be safely used in routine immunization programs to protect ch…

This study tested two experimental malaria vaccines in 345 healthy Indonesian soldiers deployed to a malaria-prone region. The goal was to see if the vaccines could safely prevent natural malaria infection. Participants received either a vaccine or a placebo, and researchers trac…

This study tested a new vaccine designed to stop the malaria parasite from spreading from people to mosquitoes. 105 healthy adults received three doses of the vaccine over several months. The main goal was to check if the vaccine is safe and triggers an immune response. Participa…

This study tested whether giving a single dose of the drug tafenoquine to everyone in three high-risk villages could safely reduce P. vivax malaria. Over 1,200 residents aged 6 months and older took part. The main goal was to check for serious side effects and see if this mass tr…

This early-stage trial tested a lab-made antibody called MAM01 in 63 healthy adults who had never had malaria. The goal was to see if it is safe and can prevent malaria infection when people are deliberately exposed to the parasite. The study is complete, but results are not yet …

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 122 African children aged 5-36 months, some living with HIV and some without. The goal was to see if the vaccine is safe and produces an immune response in these children. The trial has been c…

This study looked at whether finding and treating low-density malaria infections (infections with very few parasites) in children can improve their health and well-being over time. 600 children in Tanzania, aged 6 months to 10 years, took part. The goal was to see if this approac…

This study tested a single injection of an antibody called L9LS in healthy Kenyan children aged 5 months to 10 years. The goal was to see if it safely protects against malaria infection caused by the Plasmodium falciparum parasite. The trial involved 912 children and was complete…

This study tested a new approach to fight malaria: giving malaria medicine to everyone in a community, even if they feel fine. The goal was to remove the malaria parasite from the whole community, making it harder for mosquitoes to spread the disease. Over 3,300 people took part,…

This large phase 3 trial tested whether combining two malaria drugs (SP and DP) works better than either alone to prevent malaria and improve birth outcomes in pregnant women. Over 2,700 HIV-negative women in Uganda received monthly doses of SP, DP, or both. The study tracked com…

This study tested whether a single dose of an antibody called L9LS can safely prevent malaria in women of childbearing age in Mali. 279 healthy women and men received either the antibody or a placebo and were monitored for 24 weeks. The goal was to see if the antibody could block…

This study looked at whether specially designed homes can help prevent common illnesses like malaria, respiratory infections, and diarrhea in children under 13 in Tanzania. Over 1,100 children took part, and researchers tracked how often they got sick over time. The goal was to s…

This large study tested giving infants up to 6 doses of a malaria preventive medicine alongside their regular vaccinations during the first two years of life. Over 94,000 children in Mozambique, Sierra Leone, and Togo took part. The goal was to see if this approach could reduce m…

This study tested two kinds of long-lasting insecticide-treated bed nets across Uganda to see which better prevents malaria. Over 215,000 people took part, and researchers tracked malaria cases reported at health clinics. The goal is to find the most effective net for nationwide …

This study in Cameroon followed 406 adults with and without type 2 diabetes for one year to see if diabetes raises the risk of malaria and other parasitic infections. Researchers tested blood and stool samples at four time points. The goal was to understand how diabetes and relat…

This completed study looked at how common malaria and worm infections are in pregnant women (18 and older) and children (6-12 months old) in two counties of Liberia. Researchers tested blood samples from over 1,200 participants to measure infection rates. The goal was to gather i…

This study looked at how people's immune systems react to proteins in mosquito saliva after being bitten. Researchers exposed 147 healthy adults in Thailand to lab-grown mosquitoes that can carry malaria or dengue. The goal was to find markers in the blood that show how much expo…

This study surveyed 222 healthcare workers in Sudan to find out what they know and how they feel about the malaria vaccine. Researchers asked about awareness of the vaccine, its safety, and whether workers would recommend it. The results will help design programs to increase vacc…

This study tested a new experimental drug called MMV367 in 12 healthy adults. Participants were intentionally infected with a controlled, low-level malaria infection to see how well the drug works and how safe it is. The goal was to measure how the body processes the drug and how…

This study looked at how often people of all ages in Sabou, Burkina Faso, get malaria. Researchers checked 608 healthy volunteers monthly for a year, taking blood samples and asking about symptoms. They also collected mosquitoes from homes and did feeding experiments to understan…