MALARIA

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 122 African children aged 5-36 months, both with and without HIV. The goal was to see if the vaccine is safe and triggers a strong immune reaction in children living with HIV. Results will hel…

This study tested a new malaria vaccine called R21/Matrix-M in 594 children aged 5 to 36 months in Mali. The goal was to see if the vaccine is safe and triggers a strong immune response, both when given alone and alongside routine childhood vaccines. Researchers also compared dif…

This study tested two experimental malaria vaccines (PfSPZ Vaccine and PfSPZ-CVac) in 345 healthy Indonesian soldiers deployed to a malaria-prone region. The goal was to see if the vaccines are safe and can prevent natural malaria infection. Participants received either a vaccine…

This early-stage trial tested a new RNA-based vaccine designed to protect against malaria. Sixty healthy adults received different doses of the vaccine or a placebo to check for safety and immune response. The study was completed and will help decide if larger trials should move …

This study tested a new vaccine designed to stop the malaria parasite from spreading from people to mosquitoes. 105 healthy adults received three shots over a month. The goal was to check if the vaccine is safe and creates an immune response that could block transmission. Partici…

This study tested an experimental RNA-based vaccine (BNT165e) to prevent malaria in 163 healthy adults who had never had malaria. The vaccine uses three RNA pieces to train the immune system against the malaria parasite. Researchers checked for side effects and measured immune re…

This study tested whether giving malaria medicine to everyone in a community, even those without symptoms, could lower malaria rates in children under 15 and pregnant women. Over 3,300 people took part. The goal was to clear the malaria parasite from the community to stop mosquit…

This study tested a single injection of a lab-made antibody (L9LS) in healthy children aged 5 months to 10 years in western Kenya, where malaria is common. The goal was to see if it safely prevents Plasmodium falciparum infection. Results showed the antibody was well-tolerated an…

This large study tested giving up to 6 doses of a malaria prevention medicine to over 94,000 infants in Mozambique, Sierra Leone, and Togo during their regular vaccination visits in the first two years of life. The goal was to see if this approach is practical and effective at re…

This study in Tanzania looked at whether specially designed houses can help protect children under 13 from malaria, pneumonia, and diarrhea. Over 1,100 children living in study villages were followed to see if better housing reduces these illnesses. The goal is to find simple, la…

This study tested a new experimental drug called MMV367 in 12 healthy adults who were intentionally infected with a controlled malaria infection. The goal was to measure how the drug behaves in the body and how well it kills malaria parasites. Participants were closely monitored …

This study measured how common malaria and worm infections are in pregnant women and young children in two counties of Liberia. Over 1,200 participants gave a small blood sample for testing. The goal was to gather information to better understand disease rates in these vulnerable…

This study surveyed 222 healthcare workers in Sudan to understand their knowledge and attitudes about the malaria vaccine. Researchers asked about awareness of the vaccine, its safety, and how willing workers are to recommend it. The results will help design programs to increase …