LIVER TRANSPLANTATION

This study tests whether giving a protein called albumin after a liver transplant can lower the chance of acute kidney injury. About 400 adults receiving a new liver will be split into two groups: one gets albumin to keep levels above 30 g/L for five days, the other only gets it …

This study tests whether adding addiction monitoring after a liver transplant can reduce the rate of alcohol relapse. About 720 adults who received a liver transplant due to alcohol-related liver disease will be followed for two years. The goal is to see if this extra support hel…

This study tests whether treating donor livers with a special oxygen-rich cold fluid (HOPE) before transplant can help prevent liver cancer from coming back. About 220 adults with liver cancer and cirrhosis who are waiting for a liver transplant will take part. Half of the donate…

This study tests whether giving immunosuppressive drugs as a single daily dose after liver transplant works as well as the standard twice-daily regimen. About 162 adult liver transplant recipients will be randomly assigned to once-daily or twice-daily dosing. The goal is to see i…

This study tests whether tranexamic acid, a drug that helps blood clot, can reduce blood loss during adult liver transplant surgery. About 1,546 adults receiving a new liver will be randomly given either the drug or a placebo. The goal is to see if the drug lowers bleeding withou…

This study compares two medications, terlipressin and somatostatin, to see which one better lowers high blood pressure in the liver's main vein during a living-donor liver transplant. High pressure there can cause dangerous bleeding. About 50 adults with severe liver disease and …

This study looks at whether a structured Mediterranean diet can help people who have had a liver transplant avoid gaining too much weight and keep their heart and new liver healthy. About 80 adults who recently received a liver transplant will follow a special diet plan. The goal…

This study tests a bedside device called Quantra that quickly measures blood clotting during liver transplant surgery. The goal is to see if using this device to guide transfusions can reduce bleeding and the need for blood products compared to standard care. About 56 adults rece…

This study tests a method called normothermic machine perfusion, which keeps donated livers working outside the body so doctors can check their quality. The goal is to safely use livers that were previously considered unsuitable, helping 186 people on the transplant waiting list …

This study tests a new approach to help liver transplant recipients stop taking toxic anti-rejection drugs for good. Twelve adults who received a liver from a living donor at least one year ago will get a donor stem cell infusion after a mild radiation and antibody treatment. The…

This study tests whether an ultrasound-guided nerve block can reduce pain and the need for morphine in people who donate part of their liver. 64 donors will be randomly assigned to get either the nerve block plus standard pain relief, or standard pain relief alone. The goal is to…

This study looks at whether a specific nerve block (external oblique intercostal plane block) can better control pain after liver transplant surgery. Sixty adults getting a liver transplant will be split into two groups: one gets the nerve block plus standard care, the other gets…

This study looks at 60 adults waiting for a liver transplant to see how frailty, nutrition, and mental health affect their recovery. Participants will do simple physical tests and answer questions about their daily life and well-being. The goal is to find which patients may need …

This study is for people who have had a liver transplant and now have kidney issues. Researchers will use kidney biopsies to learn why kidney problems happen and how they get worse over time. The goal is to better understand the disease, not to test a new treatment.

This study compares two approaches to giving fluids during liver transplant surgery: one that limits fluids to reduce blood flow to the gut, and another that gives more fluids to keep the heart pumping well. The goal is to see which method leads to fewer complications after surge…