LIVER TRANSPLANTATION

This trial investigates whether adding secretin—a hormone that helps produce bicarbonate—during machine perfusion of donor livers can restore the protective 'bicarbonate umbrella' in bile ducts. Researchers will treat up to 20 donor livers with secretin while they are kept on a m…

This study looks at a new way to do liver transplants for people with severe portal hypertension. Instead of using a full-sized liver, doctors will use a smaller piece (small-for-size graft) in an auxiliary transplant, leaving part of the original liver in place. The goal is to s…

This study gives continued access to a device that preserves donated livers before transplant. It includes 120 adults on the transplant waiting list. The goal is to collect safety data and check for early signs of liver problems after surgery.

This study tests whether a digital rehabilitation platform helps people recover after a living donor liver transplant. 36 adults will be split into two groups: one gets the digital program plus standard education, the other gets standard education only. Researchers will measure p…

This study tests whether giving methadone and ketamine during a deceased donor liver transplant can lower pain and confusion after surgery. About 50 adults will receive either the drug combo or standard care. Researchers will track pain scores, opioid use, and recovery time.

This pilot study compares two approaches to giving fluids during liver transplant surgery: a restrictive strategy that removes some blood early and returns it later, versus a liberal strategy that keeps blood flow high. The goal is to see if a larger study is possible by checking…

This study compares two non-invasive methods for monitoring brain blood flow during liver transplant surgery: carotid Doppler ultrasound and near-infrared spectroscopy (NIRS). The goal is to see if the simpler, cheaper ultrasound can replace the more expensive NIRS. The study inv…

This study is testing a new blood test called LiverCare to see if it can better monitor liver transplant recipients for complications like rejection. Researchers will follow 1,500 patients for up to a year, comparing the new test with standard monitoring. The goal is to improve e…

This study looks at how social factors like income, education, and community support impact recovery in 500 children after liver transplant. Researchers will survey caregivers and interview families to understand barriers to good outcomes. The goal is to find ways to better integ…

This study follows 600 adult liver transplant recipients in Denmark for up to 10 years to understand why many develop heart, lung, kidney, or metabolic problems after transplant. Researchers will use scans, blood tests, and lung function tests to find risk factors. The goal is to…