Liver transplant study tests best way to manage fluids during surgery

NCT ID NCT05647733

Ongoing Knowledge-focused Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study compares two approaches to giving fluids during liver transplant surgery: a restrictive strategy that removes some blood early and returns it later, versus a liberal strategy that keeps blood flow high. The goal is to see if a larger study is possible by checking recruitment rates and how well doctors follow the plan. About 138 adults with end-stage liver disease will take part across four Canadian hospitals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could show which fluid management method is safer for liver transplant patients and pave the way for a larger, definitive trial.
What could go wrong: This is a small pilot study focused on feasibility, not on proving which strategy is better. Results may not apply to all patients or hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic liver failure End Stage Liver Disease liver disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END-STAGE LIVER DISEASE (ESLD) LIVER TRANSPLANTATION

Contacts and locations

Locations

Centre Hospitalier de l'Université de Montréal (CHUM)

Montreal, Quebec, H2X 0C1, Canada
London Health Sciences Centre

London, Ontario, N6G 2V4, Canada
McGill University Health Centre

Montreal, Quebec, H4A 3J1, Canada
Vancouver General Hospital

Vancouver, British Columbia, V5Z 1M9, Canada

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