KIDNEY TRANSPLANTATION

This study tested whether a single dose of tocilizumab, given right before or after removing a failed kidney transplant, can safely lower the immune system's production of antibodies that make a second transplant difficult. 18 adults who needed their graft removed and hoped for a…

This study looked at kidney transplant patients who already had one skin cancer. It compared two groups: those who switched to the drug rapamycin and those who stayed on their usual anti-rejection medicines (calcineurin inhibitors). The goal was to see if rapamycin could help pre…

This study tested a single dose of a new drug called ASKP1240 in 50 people who just received a kidney transplant. The goal was to check how the drug moves through the body, its safety, and how well it is tolerated. Participants were randomly assigned to receive either the drug or…

This study looked at whether two diabetes medications, metformin and empagliflozin, can safely improve metabolic problems (like fat distribution and blood sugar) in people who received a kidney transplant. 105 adults with stable kidney function were randomly assigned to one of th…

This early-stage study tested a new approach to help kidney transplant recipients stop taking anti-rejection drugs. Eight adults received donor stem cells along with a special drug combination, aiming to train their immune system to accept the new kidney without long-term medicat…

This study tested a new drug called FR104 in 10 people receiving a kidney transplant for the first time. The goal was to see if FR104 is safe and can help prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This study tested a new way to prevent the body from rejecting a new kidney. Instead of standard long-term drugs, patients received two antibody infusions right after transplant, followed by just one maintenance drug. The goal was to see if this simpler approach could keep the ki…

This study tested a new combination of two drugs (belatacept and a proteasome inhibitor) in 5 highly sensitized kidney transplant candidates. The goal was to lower their strong immune antibodies so they could find a compatible donor. The approach aims to safely increase the chanc…

This study tested whether giving donor stem cells along with a kidney transplant could allow patients to safely stop taking anti-rejection drugs after one year. It involved 88 people who received a kidney from a matched sibling. The goal was to see if the body would accept the ne…

This study looked at whether using a patient's genetic information to set the starting dose of tacrolimus (an anti-rejection drug) leads to better drug levels in the blood after a kidney transplant. 280 adults receiving a kidney transplant were randomly assigned to get either a s…

This study tested a new medicine called CFZ533 to see if it could prevent kidney transplant rejection as well as the standard drug tacrolimus. About 418 kidney transplant patients took part. The goal was to compare how many patients had rejection, lost their kidney, or died withi…

This study tested a new medicine called ASKP1240 in 149 people who received a new kidney. The goal was to see if it could help prevent the body from rejecting the new kidney. The study compared different combinations of drugs to find a safer and more effective way to protect the …

This study involved 81 children who had received an organ transplant (like kidney, liver, or heart) and were taking a standard anti-rejection drug called Prograf. Researchers wanted to see if switching to a longer-acting version called Advagraf was safe and worked just as well. T…

This study tested a special stent with a magnetic end in 67 children with urinary tract problems or kidney transplants. The goal was to see if doctors could remove the stent without surgery or anesthesia, using a magnetic tool in the clinic. The study checked if this method was s…

This study looked at 241 kidney transplant patients to see how certain antibodies (AT1R-Ab) change before and after transplant. Researchers measured antibody levels over one year to understand their impact on kidney function and graft survival. The goal is to help doctors better …

This study looked at whether substances in a small piece of the donor kidney can predict how well the organ will work after transplant. Researchers tested blood, urine, and biopsy samples from 24 kidney transplant recipients. The goal was to find early signs that might show if th…

This study looked at how pancreas-kidney transplants change bile acids and blood sugar control in people with type 1 diabetes and kidney disease. Researchers measured bile acid levels and glucose responses in 50 transplant patients, comparing them to kidney-only transplant patien…

This study looked at whether a simple urine test could predict kidney scarring (fibrosis) after a kidney transplant, instead of doing an invasive biopsy. Researchers measured certain genetic markers in the urine of 300 kidney transplant recipients over the first year after surger…

This study followed 72 kidney and lung transplant patients for one year to see how their hand tremors changed over time. Tremors are a common side effect of the anti-rejection drugs (calcineurin inhibitors) that patients must take. Researchers measured tremor severity using spira…