KIDNEY TRANSPLANTATION

This study looked at whether giving kidney transplant patients a lower dose of the drug cyclosporine could protect their kidney function over time. 208 patients who were at least one year post-transplant and on stable medications took part. The goal was to balance preventing orga…

This pilot study tested a new combination of two drugs, Alemtuzumab and Infliximab, given right after a kidney transplant to prevent rejection. The goal was to see if patients could avoid long-term steroids and calcineurin inhibitors. Twenty first-time kidney transplant recipient…

This study tested a new drug called CFZ533 in 418 kidney transplant patients to see if it could prevent organ rejection as well as the standard drug tacrolimus. Patients received either CFZ533 or tacrolimus along with other standard medications. The main goal was to compare rates…

This study looked at whether two diabetes drugs, metformin and empagliflozin, can safely improve metabolic problems (like unhealthy fat buildup and blood sugar issues) in people who have had a kidney transplant. 105 kidney transplant recipients with good kidney function were rand…

This study tests whether giving donor stem cells and a drug called Campath-1H can help kidney transplant recipients stop taking anti-rejection medications permanently. Eighty-eight patients receiving a kidney from an identical sibling will get the stem cell infusions and temporar…

This early-stage study tested a new approach to help kidney transplant recipients stop taking anti-rejection drugs. Eight adults received donor stem cells along with a special mix of medications to see if their bodies would accept the new kidney without needing lifelong drugs. Th…

This study tested a new drug called FR104 in 10 people who received a kidney transplant. The goal was to see if the drug is safe and helps prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This phase 2 pilot study tested whether a single dose of tocilizumab, given before or after removing a failed kidney transplant, is safe and can reduce harmful antibodies that make a second transplant difficult. The study involved 18 adults who needed their kidney graft removed a…

This study looked at kidney transplant patients who already had one skin cancer. It compared switching their anti-rejection medicine to rapamycin versus staying on standard drugs. The goal was to see if rapamycin could prevent new skin cancers over two years while keeping the tra…

This pilot study tested a combination of two drugs—belatacept and a proteasome inhibitor—to lower strong immune antibodies in 5 highly sensitized kidney transplant candidates. The goal was to increase their chances of finding a compatible donor. The study has completed, but resul…

This study tested whether children who had received an organ transplant (kidney, liver, heart, lung, or intestine) could safely switch from taking tacrolimus twice a day (Prograf) to a once-daily version (Advagraf). The goal was to see if the once-daily pill provided similar drug…

This study tested a new medicine called ASKP1240 in 149 people who received a new kidney. The goal was to see if it could prevent the body from rejecting the kidney as well as or better than current standard treatments. Participants received different combinations of drugs, and r…

This study tested a single dose of a new drug called ASKP1240 in 50 people who just received a kidney transplant. The goal was to see how the drug moves through the body, how safe it is, and how well it works. Participants were randomly assigned to get the drug or a placebo, and …

This study tested whether adjusting the first dose of the immunosuppressant drug tacrolimus based on a patient's CYP3A5 gene helps reach the right blood levels faster after kidney transplant. 280 kidney transplant recipients were randomly assigned to receive either a standard dos…

This study tested whether analyzing proteins from kidney biopsy and urine samples can improve the diagnosis of microvascular inflammation, a key sign of antibody-mediated rejection in kidney transplant recipients. Researchers used mass spectrometry to find protein signatures in 1…

This study tested whether giving intravenous immunoglobulins (IVIG) could prevent BK virus infection in kidney transplant recipients. The virus often causes graft problems. Researchers enrolled 359 patients with low antibody levels against their donor's virus strain and gave some…

This study tested a new way to prevent CMV infection in 42 CMV-positive kidney transplant patients. Researchers combined an antibody infusion with a specific type of immune cell (gamma delta T cells) to see if it could stop the virus from reactivating. The goal was to find a safe…

This study tested a special ureteral stent with a magnetic end in 67 children with urinary tract problems or kidney transplants. The goal was to see if the stent could be removed without general anesthesia, using a magnetic catheter instead. The approach aims to make the removal …

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This early-stage study tested a new drug, SHR-2106, in 52 healthy adults to see if it is safe and how the body processes it. Participants received a single dose either through a vein or under the skin. The goal was not to treat any disease, but to gather important safety informat…

This pilot study tested a shared decision-making tool called the Donor Offer Plan (DOP) for people on the kidney transplant waiting list. 100 participants reviewed an online education module and discussed their donor preferences with a transplant nurse. The goal was to see if thi…

This study looked at how levels of a specific antibody (AT1R-Ab) change before and after kidney transplantation in 241 patients. Researchers monitored these antibodies over one year to see if they relate to kidney function and graft survival. The goal is to find better ways to pr…

This study looked at whether a simple urine test could predict scarring in kidney transplants, instead of using a needle biopsy. Researchers measured certain genetic markers in urine cells from 300 kidney transplant recipients over the first year after transplant. The goal was to…

This study looks at how pancreas-kidney transplantation changes bile acids and gut-related metabolism in people with type 1 diabetes and kidney disease. Researchers will measure bile acid levels and glucose responses in 50 transplant patients, comparing them to kidney-only transp…

This study looked at small pieces of donor kidney tissue to see if certain substances could predict how well the organ would work after transplant. Researchers tested blood, urine, and biopsy samples from 24 kidney transplant recipients. The goal was to find early signs of organ …

This study followed 72 kidney and lung transplant recipients for one year to see how hand tremors—a common side effect of anti-rejection drugs—change over time. Researchers used spiral drawings and wrist-worn accelerometers to measure tremor severity. The goal was to understand t…