KIDNEY TRANSPLANTATION

This study tested a new approach to help kidney transplant patients stop taking lifelong anti-rejection drugs. It involved 88 patients who received a kidney from a genetically matched sibling. The treatment combined a special medication (Campath-1H) with infusions of the donor's …

This early-stage study tested a new antibody called FR104 in 10 people who recently received a kidney transplant. The goal was to see if FR104 is safe and might help prevent the body from rejecting the new kidney. Researchers monitored patients for side effects, especially infect…

This study tested a new antibody drug called CFZ533 to see if it could prevent organ rejection in kidney transplant patients as well as or better than the standard medication, tacrolimus. It involved 418 adults who had recently received a transplant or were maintaining a transpla…

This small pilot study tested whether a combination of two drugs (belatacept and a proteasome inhibitor) could safely help patients who are 'highly sensitized'—meaning their immune systems are primed to reject most donor kidneys—find a compatible donor. The goal was to lower thei…

This study tested if switching children with stable organ transplants from a twice-daily anti-rejection pill (Prograf) to a new once-daily version (Advagraf) was safe and kept the right amount of medicine in their blood. It involved 81 children who had received a heart, kidney, l…

This study tested whether a new antibody drug called ASKP1240 could help prevent organ rejection after kidney transplantation. Researchers compared the new treatment to standard anti-rejection medications in 149 patients who received new kidneys. The goal was to see if the new ap…

This study tested if a single dose of the drug tocilizumab, given around the time a failed kidney transplant is surgically removed, is safe and can help reduce harmful antibodies. These antibodies often form after removal and make it very difficult for patients to receive a secon…

This study tested if adjusting the starting dose of a common anti-rejection drug (tacrolimus) based on a patient's genetics could help get the drug level right more quickly after a kidney transplant. 280 kidney transplant recipients were randomly assigned to receive either a stan…

This study tested whether switching kidney transplant patients who developed their first skin cancer from one type of anti-rejection drug (calcineurin inhibitors) to another (rapamycin) could prevent new skin cancers from forming over two years. It involved 77 patients who had re…

This study tested if two common diabetes medications, metformin and empagliflozin, could safely improve metabolism and reduce heart disease risk in people who have received a kidney transplant. It involved 105 recent transplant recipients, with or without diabetes, who were rando…

This small, early-stage study tested whether a combination of donor cells and specific immunosuppressive drugs could allow kidney transplant recipients to slowly reduce and potentially stop all anti-rejection medications without rejecting their new kidney. The goal was to see if …

This was an early safety study to test a new drug called ASKP1240 in people who recently received a kidney transplant. The main goal was to see how the drug moves through the body, how it affects the immune system, and if it is safe and tolerable. The study involved 50 participan…

This study tested whether a non-invasive urine test could predict dangerous scarring in transplanted kidneys. Researchers followed 300 kidney transplant patients for a year, analyzing genetic markers in their urine. The goal was to see if this test could accurately identify patie…

This study tested a new magnetic ureteral stent in children who needed one for kidney problems or transplants. The goal was to see if the stent could be safely removed in a clinic using a magnet, avoiding a second procedure under general anesthesia. Researchers also looked at cos…

This study aimed to understand how a common side effect—tremor or shaking—changes over time in people who have received a kidney or lung transplant. Researchers followed 72 transplant patients for one year to measure the severity of their tremor, which is often caused by the esse…

This study followed 241 kidney transplant patients to see if tracking a specific antibody (AT1R-Ab) in their blood before and after surgery could help predict how well the new kidney would work. Researchers measured antibody levels at several points over a year and checked for si…

This study aimed to understand why some type 1 diabetes patients who receive a combined pancreas and kidney transplant still have blood sugar issues. Researchers measured changes in gut chemicals (bile acids), gut bacteria, and hormone levels in 50 transplant patients one year af…

This study aimed to find early warning signs in donor kidney tissue that could predict future problems for transplant recipients. Researchers tested small tissue samples, blood, and urine from 24 kidney transplant patients. They looked for specific markers that might signal if th…