KIDNEY TRANSPLANTATION

This study tests imlifidase, a drug that temporarily disables the immune system's antibodies, allowing highly sensitized patients to receive a kidney from a deceased donor they would otherwise reject. The trial will follow 450 patients in France to see how many get transplanted a…

This study tests whether a nurse-led program of education and telephone counseling can help kidney transplant recipients take their anti-rejection medications more consistently. Sixty adult patients will be randomly assigned to either the program or standard care. The goal is to …

This study will check if a muscle ultrasound can reliably detect muscle loss (sarcopenia) in 140 adults getting a kidney transplant. Researchers will compare ultrasound results with a standard body-composition test before and up to one year after transplant. If it works, this cou…

This study tests whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose to prevent a serious lung infection called PJP in people who have just had a kidney transplant. About 1,084 adult first-time kidney transplant recipients will take either a low or s…

This study compares a new 'tubeless' anesthesia method (using a laryngeal mask and lighter sedation) to standard breathing-tube anesthesia in 60 kidney transplant patients. The goal is to see if it reduces the need for muscle relaxants and other drugs, and improves recovery. Part…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study follows 150 adults waiting for a kidney transplant to track how their physical and emotional health changes over time. Researchers will use a mobile app and interviews to measure frailty and quality of life. The goal is to identify patients who need extra support and i…

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This study tracks BK virus in saliva, urine, and blood of 100 kidney transplant recipients over one year. The goal is to see if the virus spreads through saliva and how it affects the new kidney. Participants collect their own saliva samples at home, plus give urine and blood at …

This study interviews 15 people who have donated a kidney to understand their feelings about receiving a symbolic token of gratitude, like a commemorative medal. Researchers want to learn if such recognition could improve donors' experience and encourage more donations. The study…

This study looks at how CMV (a common virus) changes the immune system in people who have had a kidney transplant. Researchers will take blood samples from 60 patients to compare immune responses in those with and without CMV infection. The goal is to understand why CMV may incre…