CHRONIC MYELOID LEUKEMIA

This study tests whether the drug olverembatinib can safely control chronic myeloid leukemia (CML) in its early phase. About 50 adults with newly diagnosed CML will take the drug alone and be monitored for side effects and disease response. The goal is to see if this treatment ca…

This study tests an experimental pill called HQP1351 in people with chronic myeloid leukemia (CML) or a type of acute lymphoblastic leukemia (Ph+ ALL) that has not responded to at least two prior treatments. The goal is to find the best dose and see how safe and effective the dru…

This study is for people with certain blood cancers (like leukemia) who are getting a half-matched bone marrow transplant. Researchers are adding a dose of specially grown immune cells (gamma delta T-cells) after the transplant to see if it can kill any leftover cancer cells whil…

This study tests a new drug called ELVN-001 for people with chronic myeloid leukemia (CML) whose cancer has stopped responding to or who cannot tolerate current treatments. About 250 adults with CML will receive the drug to find the safest dose and check for side effects. The goa…

This study tests whether the drug asciminib can help control chronic myeloid leukemia (CML) in people who were recently diagnosed. About 50 adults will take the drug, and researchers will watch for side effects and how well it works. The goal is to manage the disease, not to cure…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This early-phase study tests a combination of two drugs, selumetinib and azacitidine, in about 18 adults with higher-risk blood cancers like MDS, MDS/MPN, and myelofibrosis. The main goal is to find the safest dose of selumetinib when given with standard azacitidine. Treatment co…

This study tests a new combination of drugs (bendamustine and cyclophosphamide) to prevent graft-versus-host disease and a dangerous immune reaction after stem cell transplants. It involves 60 adults with high-risk blood cancers who have a partially matched donor. The goal is to …

This early-stage study tests a new drug called MGD024 in about 130 adults with certain blood cancers (like leukemia or lymphoma) that did not get better with standard treatments or came back. The main goal is to find a safe dose and understand side effects. Participants receive t…

This study tests a new daily pill, TERN-701, for people with chronic myeloid leukemia (CML) whose current treatments are not working well or cause side effects. About 180 adults will take the pill once a day to see if it is safe and can control their cancer. The goal is to find t…

This study monitors 600 Korean adults with chronic myeloid leukemia who are taking Scemblix (asciminib) as part of their regular care. Researchers will track side effects and how well the drug controls the disease over time. The goal is to confirm the drug's safety and effectiven…

This early-stage study tests a new drug called CBX-250 in about 72 people with certain blood cancers (like acute myeloid leukemia) that have returned or not improved with standard therapy. The main goals are to check the drug's safety and find the best dose. Participants receive …

This early-stage study tests a new treatment for children and adults with acute leukemia that has come back or not responded after a donor stem cell transplant. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack a protei…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to help researchers develop and improve blood tests that can detect many types of cancer early. Participants provide samples that are stored and later used to test new diagnostic methods.…

This study explores whether a person's personality traits influence how consistently they take their daily oral medication for chronic myeloid leukemia (CML). Researchers will observe 75 adults with CML who are already on standard therapy. The goal is to better understand barrier…