New pill shows promise for leukemia patients who've run out of options

NCT ID NCT04260022

Recruiting now Disease control Sponsor: Ascentage Pharma Group Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an oral drug called HQP1351 in people with chronic myeloid leukemia (CML) or a type of acute lymphoblastic leukemia (Ph+ ALL) that has not responded to at least two other treatments. The goal is to find the right dose and see how safe and effective the drug is. About 242 participants will take the pill by mouth, and researchers will monitor drug levels in the blood and any side effects.

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Conditions

The condition(s) this trial relates to.

blast phase chronic myelogenous leukemia, BCR-ABL1 positive Burkitt lymphoma chronic myelogenous leukemia, BCR-ABL1 positive leukemia, acute lymphocytic, susceptibility to, 1 Leukemia, Myelogenous, Chronic, BCR-ABL Positive myeloid leukemia precursor B-cell acute lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B CELL PRECURSOR TYPE ACUTE LEUKEMIA CHRONIC MYELOID LEUKEMIA LEUKEMIA,MYELOID, CHRONIC MYELOID LEUKEMIA PHILADELPHIA POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

Contacts and locations

Locations

Augusta Cancer Center
RECRUITING

Augusta, Georgia, 30912, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Winship Cancer Institute, Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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