BACK PAIN

This study tests whether a combination of counseling and a muscle relaxant (tizanidine) can help people who have used opioids for a long time reduce or stop their pain medication after elective surgery. The trial involves 375 adults aged 18–75 who have been on opioids for at leas…

This study tests a synthetic bone graft material called MagnetOs Easypack Putty for spinal fusion surgery. The goal is to see if it works as well as or better than current bone graft materials when used alone. About 60 adults with back pain or spine instability from disc disease …

This study is testing whether taking cannabis by mouth can safely reduce chronic back or neck pain and help people cut down on strong painkillers like opioids. About 157 adults with pain lasting at least 3 months will receive either cannabis or a placebo. The goal is to see if ca…

This study tests whether adding shock wave therapy to core stability exercises helps reduce chronic back pain in female university students. One hundred participants with non-specific back pain lasting over three months will be enrolled. The main goal is to measure pain relief an…

This study compares two common injection treatments for chronic mid-back muscle pain: trigger point injections and erector spinae plane blocks. About 76 adults with persistent mid-back pain will be randomly assigned to receive one of the two treatments. Researchers will track pai…

This study tests whether Pain Reprocessing Therapy (PRT) works better than Cognitive Behavioral Therapy (CBT) or usual care for veterans with long-term back or neck pain. PRT teaches the brain to reinterpret pain signals as less threatening. 360 veterans will be randomly assigned…

This study tests whether dry needling—a technique where thin needles are inserted into muscles—can reduce pain and improve quality of life for people with chronic low back pain. Researchers will also check if the approach is practical and acceptable. The study includes 42 adults,…

This study compares an 8-week mindfulness-based stress reduction (MBSR) course to usual care for working-age adults (18–64) with back pain lasting over 12 weeks. Half of the 120 participants will take the course, and all will be followed for 2 years. The goal is to see if mindful…

This study tests whether a small device that sends mild electrical pulses through the skin (TENS) can quickly reduce acute low back pain in people visiting the emergency department. About 222 adults with recent back pain will receive either real TENS or a placebo device for 30 mi…

This early-stage study tests whether an injection of Alocyte (a mix of cord blood plasma and cells) into the small joints of the spine is safe and can reduce pain from worn facet joints. About 15 adults with chronic low back pain will receive one of three doses. The main goal is …

This study tests whether a special posture training program can help butchers with neck and upper back pain. Researchers will enroll 50 butchers in Istanbul who have worked in the trade for at least 5 years. The program focuses on improving muscle control and posture. The goal is…

This study tests whether cannabidiol (CBD), a non-intoxicating cannabis compound, can reduce brain inflammation in 80 adults with chronic low back pain, with or without mild-to-moderate depression. Participants will receive either CBD or a placebo, and researchers will measure ch…

This study looks at why some women with larger busts have long-term neck, shoulder, arm, and back pain. Researchers will test if special sports bras help, and also check how hormones, inflammation, and brain changes might play a role. About 140 women aged 18 to 60 will take part.

This study looks at how many medical students at the University of the West Indies, Mona, have neck or low back pain. It also checks what students know about spine health and tests whether a standard exercise program can reduce their pain. About 1,000 students will take part, and…

This study tests whether a smartphone app called Medidux can help patients with non-urgent issues like cough, back pain, or stomach pain avoid going back to the hospital after they are discharged. About 417 adults will either use the app to track symptoms for a week or receive st…

This study explores how having other chronic health issues alongside back or neck pain impacts diagnosis, treatment, and long-term recovery. Researchers will track 2,000 adults referred to Danish hospital clinics to understand these connections. The goal is to improve care for pe…

This study looks at how stress changes the way opioid pain medications work in people with long-term back pain. Researchers want to understand if high stress levels increase the risk of misusing these drugs. About 120 adults with daily back pain will take part in lab sessions to …

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…