ANAPLASTIC ASTROCYTOMA

This study tests a new way to deliver a cancer drug directly to the brain along with repeat radiation for people whose aggressive brain tumors have come back. The drug, cetuximab, targets a protein common on these cancer cells. The goal is to see if this combination can stop tumo…

This study tests whether giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and works for children and young adults under 22 whose brain tumors have come back or not responded to treatment. About 20 participants will rec…

This study tests two drug combinations given after radiation for children and young adults with aggressive brain tumors (high-grade glioma or DIPG). One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The goal is to see if these combinations …

This study tests the drug lorlatinib in children (ages 1 to 21) with a newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given with or after other …

This early-stage trial tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and understand side effects. About 102 participants will receive the drug weekly or multiple days per week.

This study follows children who previously took dabrafenib and/or trametinib for certain brain tumors. It aims to see how safe these drugs are over the long term by tracking side effects and monitoring growth. About 163 children are enrolled, and the study is no longer recruiting…

This study tests a new treatment for people with aggressive brain tumors like glioblastoma. It combines a genetically modified virus (M032) that attacks tumor cells and boosts the immune system, with the immunotherapy drug pembrolizumab. The goal is to see if this combination is …

This study tests a new gene therapy (HSV-tk) plus valacyclovir, given alongside standard radiation and chemotherapy, for people newly diagnosed with aggressive brain tumors (glioblastoma or anaplastic astrocytoma). The goal is to see if this combination can help patients live lon…

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a fast-growing brain tumor) has returned after standard treatments. The drugs are temozolomide (given in low, frequent doses) and abexinostat (an experimental pill). The main goal is to fi…

This study is for children, teens, and young adults (ages 1 to 39) newly diagnosed with a high-grade glioma, a serious type of brain tumor. Researchers will analyze the tumor's genetic makeup to see if it matches a specific treatment plan in a future study. The goal is to learn m…