ANAPLASTIC ASTROCYTOMA

This trial aimed to test whether adding a gene therapy (Toca 511) and a special pill (Toca FC) to standard radiation and chemotherapy could help people with a newly diagnosed aggressive brain cancer called glioblastoma. The treatment was designed to turn cancer cells into drug fa…

This study tests whether two targeted drugs, dabrafenib and trametinib, given after radiation therapy can help children and young adults (up to age 25) with a specific type of aggressive brain cancer called BRAF V600-mutant high-grade glioma. The drugs block signals that help can…

This study tests whether adding the drug veliparib to standard radiation and chemotherapy can help children and young adults with a fast-growing brain tumor called high-grade glioma. Veliparib blocks a protein that helps cancer cells repair themselves, potentially making treatmen…

This study tests whether doing extra MRI scans each week during radiation treatment can help doctors adjust the radiation plan to better target high-grade gliomas, a type of aggressive brain tumor. About 20 adults with newly diagnosed tumors will receive standard radiation plus w…

This early-phase study tests a cancer vaccine called SurVaxM in 35 children with brain tumors that have come back or are hard to treat. The vaccine is designed to teach the body's immune system to find and destroy tumor cells carrying a protein called survivin. The goal is to see…

This study looks back at how 1,000 adults with recurrent malignant gliomas (a type of brain tumor) responded to chemotherapy and targeted therapy. The goal is to learn which treatments work best for different tumor types. No new treatments are given; the study simply collects dat…