ALCOHOL USE DISORDER (AUD)

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This early-stage study tests whether the psychedelic DMT, combined with talk therapy, can help people with alcohol use disorder drink less. About 63 adults with alcohol use disorder will receive either DMT or a placebo in a controlled setting. Researchers will monitor safety and …

This study is testing whether a combination of ketamine (a medication) and real-time brain training (neurofeedback) can help people with alcohol use disorder reduce their drinking. About 75 adults aged 18-65 who want to cut back or stop drinking will receive either ketamine or a …

This study tests whether a non-invasive brain stimulation technique called deep TMS can help veterans with alcohol use disorder reduce relapse. One hundred participants will receive the treatment and be followed for three months to track drinking days and brain activity changes. …

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce heavy drinking and the brain's response to alcohol-related images. About 86 adults with alcohol use disorder will receive either real or fake TBS over the fron…

This study tests a smartphone app that uses machine learning to send personalized messages to people recovering from alcohol use disorder. The goal is to see if these messages can help participants reduce heavy drinking and stay engaged with their recovery. About 416 adults who h…

This study looks at whether adding a smartphone app to standard medication helps Veterans with alcohol use disorder reduce heavy drinking more than medication alone. About 330 Veterans from VA primary care will take part. The app aims to make it easier to get both treatments with…

This study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. About 184 adults who want to cut back or quit drinking will take the drug or a placebo and report their drinking and cravings. The goal is to …

This study tests whether two moderate-to-high doses of LSD, given in a therapeutic setting, can help people with alcohol use disorder reduce heavy drinking. 128 adults who have recently stopped drinking will receive either a low or high dose of LSD and be followed for 30 weeks. T…

This study tests whether a medication already approved for other uses can help people with HIV who also have alcohol use disorder drink less. Researchers will enroll 30 adults from the Atlanta VA Healthcare System. Participants will receive the medication along with counseling fr…

This early-phase study tests whether a sublingual form of dexmedetomidine (BXCL501) is safe and shows promise for treating alcohol use disorder in people who also have PTSD. Ten heavy drinkers with PTSD will take the drug and be monitored for changes in blood pressure, anxiety, a…

This study is creating and testing a short, online therapy program for LGBTQ+ people who have experienced trauma and drink alcohol. In the first phase, participants share their thoughts to make the program more helpful and welcoming. In the second phase, some participants can try…

This study tests a smartphone app designed to help teenagers and young adults with alcohol or cocaine use disorder improve their self-control around substance-related cues. Researchers will recruit 210 participants aged 14 to 35 from treatment centers. Half will use an app with s…

This early-phase study tests whether diclofenac, a common anti-inflammatory drug, can increase a brain-protecting chemical and reduce alcohol cravings in people with Alcohol Use Disorder. 24 participants will receive different doses or a placebo across four sessions. The goal is …

This pilot study tests whether tirzepatide, a drug used for diabetes, can help reduce cravings for alcohol in people with alcohol use disorder. Twenty adults will receive weekly injections of either the drug or a placebo for 4 weeks. The goal is to see if the drug lowers cue-trig…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study tests whether using a life history calendar—a simple grid that helps people remember important life events—can improve how accurately adults in Hong Kong recall and report mental health conditions like depression, anxiety, and PTSD. Researchers will compare the standar…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This early-phase study looks at how tirzepatide, a drug used for diabetes and weight loss, affects brain chemistry in people with alcohol use disorder (AUD) and healthy volunteers. Researchers will use brain scans to measure dopamine levels after taking the drug or a placebo. The…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers will use brain scans, computer games, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to pr…