AGE RELATED MACULAR DEGENERATION

This early-stage study tests the safety of a new drug called BBC1501, given as an injection into the eye, for people with wet age-related macular degeneration (nAMD). The trial involves 18 adults aged 50 and older who have already received standard treatment. The main goal is to …

This study tests the safety of a monthly eye injection called ASP3021 in 20 Japanese adults aged 40 and older who have geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. Participants will receive 12 monthly injections into the affecte…

This study tests whether high-dose atorvastatin (a statin drug) can improve vision in people with intermediate age-related macular degeneration (AMD). Researchers will measure how quickly participants' eyes adjust to darkness and track changes in fatty deposits (drusen) in the re…

This study tests a personalized treat-and-extend approach using faricimab for people newly diagnosed with polypoidal choroidal vasculopathy (PCV), a form of wet age-related macular degeneration. The goal is to see if this regimen can safely extend the time between eye injections …

This study tests whether taking krill oil capsules daily for 3 months can reduce drusen (fatty deposits) in the eyes of people with early or intermediate dry age-related macular degeneration (AMD). 24 adults will receive either krill oil or a placebo. The main goal is to see if t…

This study tests a new medicine called tiespectus (EYE201) for wet age-related macular degeneration, a leading cause of vision loss. About 960 people will receive either tiespectus or the standard treatment aflibercept via eye injections. The goal is to see if tiespectus can impr…

This study looks at how well a biosimilar drug called Yesafili works for people with wet age-related macular degeneration (AMD). About 54 participants will switch from the standard drug Eylea to Yesafili. Doctors will check vision and eye health to see if the biosimilar is a safe…

This early-stage study tests a stem cell therapy called ASP7317 for people with geographic atrophy, the advanced form of dry age-related macular degeneration that causes central vision loss. The treatment involves injecting special cells under the retina to replace damaged ones. …

This early-stage study tests a new treatment called C.001 for people with retinal diseases that cause vision loss, such as geographic atrophy and Stargardt disease. The treatment is given as a single injection into the eye. The main goal is to check if it is safe, and researchers…

This study tests a device that delivers very mild electrical stimulation through the eyelid to treat dry age-related macular degeneration (AMD), a leading cause of vision loss. About 100 people with intermediate to advanced dry AMD will receive either the real treatment or a sham…

This study tests a new drug called VOY-101 in 60 people aged 60 and older with advanced dry age-related macular degeneration (AMD), a leading cause of vision loss. The goal is to see if VOY-101 can slow the growth of damaged areas in the retina and help preserve eyesight. The tri…

This study tests a new medicine called tiespectus (EYE201) for wet age-related macular degeneration, a leading cause of vision loss. About 960 people will receive either tiespectus or the standard treatment aflibercept via eye injections. The goal is to see if tiespectus works as…

This study tests a new medicine called ABBV-6628 for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. About 66 adults aged 50 and older will receive eye injections of the study drug or an approved treatment to check…

This study is testing a new, non-invasive camera that takes detailed pictures of the back of the eye using many colors of light. The goal is to see if this method can find early signs of common eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma…

This study tests whether vision screenings in Danish general practice can detect vision problems early in people over 70 who have at least one chronic condition. About 460 participants will take vision tests at their GP and an optometrist. The goal is to find vision loss or eye d…

This study tests a new way to detect age-related macular degeneration (AMD) earlier than current methods. Researchers will use special laser light patterns to see if people with early AMD perceive them differently than those with healthy vision. The goal is to catch the disease b…

This study tests a small telescope implant for people with end-stage age-related macular degeneration (AMD) who have lost central vision. About 76 adults aged 55 and older will receive the implant and be followed for 12 months. The goal is to see if the device safely improves vis…

This early-stage study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may reduce harmful activity in the retina. The stud…

This study tests whether teaching people with age-related macular degeneration, diabetic retinopathy, or glaucoma simple strategies—like using extra lighting, large-print labels, and smartphone apps—can help them manage their medications with fewer errors. About 50 participants w…

This study looks at whether shifting text to undamaged areas of the visual field can improve reading for people with central vision loss due to age-related macular degeneration. About 108 participants with central vision loss (and some with simulated vision loss) will read words …

This study uses a special camera called the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) to take very detailed pictures of the retina in people with inherited retinal degenerations like retinitis pigmentosa. Researchers want to see how the structure and function of the r…

This study collects blood, tissue, and health information from people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. Researchers will store these samples and data in a database for future studies. No treatment is given. The goal …

This study uses a special camera to take ultra-detailed pictures of the retina (the back of the eye) in both healthy people and those with eye diseases like Stargardt's or age-related macular degeneration. The goal is to see individual cells and blood vessels to better understand…

This study is creating a large database of eye measurements from 3,000 people with inflammatory eye diseases like diabetic retinopathy and age-related macular degeneration. Researchers will use advanced imaging to capture details of both the eye surface and the retina. The goal i…

This study aims to understand why 20-40% of people with wet age-related macular degeneration (AMD) do not respond well to standard anti-VEGF injections. Researchers will analyze fluid samples from inside the eyes of 117 patients, comparing those who respond well to those who don'…

This study looks at whether taking a daily mix of lutein, zeaxanthin, and fish oil for six months can improve thinking skills, eye health, and bone density in healthy adults. About 80 participants will take either the supplement or a placebo. The goal is to see if these nutrients…

This study will collect eye images from 1,000 adults aged 50 and older, both healthy and those with age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a diverse, high-quality dataset that researchers can use to develop artificial intelligence (…

This study uses a special camera called adaptive optics to take detailed pictures of the back of the eye in people with outer retinal diseases like age-related macular degeneration and retinitis pigmentosa. Researchers want to develop better ways to diagnose and track these condi…

This study looks at different ways to help people who have been referred to an eye hospital after a screening. 3000 participants will be split into three groups: some get text reminders, some get calls from health workers, and some get no reminders. The goal is to see which metho…

This study aims to define a new concept called 'visual frailty' in people aged 60 and older with age-related macular degeneration (AMD). Researchers will measure vision, reading ability, daily function, mental health, and other health conditions to understand how these factors in…

This study compares two imaging techniques—central microperimetry and radial OCT—to see if they can more accurately measure the growth of geographic atrophy (a severe form of age-related macular degeneration) toward the center of the retina. Researchers will follow 80 adults aged…

This study watches how early damage in age-related macular degeneration (AMD) grows over time. Researchers will use special eye scans to measure changes in the retina and see how they affect vision and daily life. The goal is to find better ways to detect and track the disease ea…