Urolithiasis

This trial compares two common procedures for treating upper ureteric stones: extracorporeal shock wave lithotripsy (ESWL), which uses external shock waves to break the stone, and semirigid ureteroscopy, where a thin scope is passed through the urinary tract to fragment the stone…

This trial tests whether lanthanum carbonate, a drug typically used to bind phosphate, can also reduce oxalate levels in urine. People with secondary hyperoxaluria and a history of kidney stones take the drug with meals for 28 days, with the dose increasing after two weeks. The g…

This study compared three procedures for removing hard kidney stones that are not in the lower part of the kidney: flexible ureteroscopy (FURS), shock wave lithotripsy (ESWL), and mini-percutaneous nephrolithotomy (Mini-PCNL). 300 adults with a single stone up to 2 cm were random…

This study tested a device called Break Wave™ that uses focused ultrasound waves to break kidney stones into tiny pieces that can pass naturally. 64 adults with upper urinary tract stones (4-10 mm) received the treatment. The goal was to see if the device is safe and effective at…

This study tested a new tool called the CVAC System, a steerable catheter that helps remove kidney stones during a procedure called ureteroscopy. Thirty adults with kidney stones took part. The main goal was to see how safe the device is and how well it clears stones, measured by…

This study tested a new miniature endoscope called the 'Aircraft Nephroscope' for removing kidney stones. 216 patients underwent surgery with this device to see if it is safe and effective. The main goal was to check how many stones were completely removed and how many complicati…

This study tested a new way to remove kidney stone pieces after laser treatment. Instead of using a tiny basket to grab each fragment, the SURE procedure gently vacuums them out. Researchers compared how many patients became completely stone-free with each method in 132 adults. T…

This study tested whether taking a harmless bacterium called Oxalobacter formigenes could help it live in the gut and reduce the amount of oxalate passed in urine. High urine oxalate is a major risk factor for calcium oxalate kidney stones. Twenty-six healthy adults who did not a…

This study compared two procedures for removing dense kidney stones in children aged 2 to 12: shock wave lithotripsy (SWL) and miniaturized percutaneous nephrolithotomy (mini-PNL). One hundred children with a single, medium-sized, high-density stone were randomly assigned to one …

This study tested a citrate mixture (citric acid, potassium bicarbonate, and sodium citrate) to dissolve coral-like urate kidney stones in 49 patients. The goal was to see if the treatment could shrink or eliminate stones, potentially avoiding surgery. Patients took a personalize…

This study tests whether new software for ultrasound machines can better detect and measure kidney stones compared to standard methods. Researchers will scan 370 adults with known calcium-based kidney stones and compare the results to CT scans and surgical findings. The goal is t…

This study tested whether an ultra-low-dose CT scan, combined with a deep-learning AI reconstruction, can accurately detect urinary tract stones. 62 adults with known or suspected kidney stones received both a standard low-dose CT and an additional ultra-low-dose scan (less than …

This study tested whether a green dye injected into the blood can help surgeons see bile ducts better during gallbladder removal for acute cholecystitis, compared to the standard contrast dye. 156 adults with mild to moderate gallbladder inflammation took part. The goal was to se…

This study tested whether a program to help people drink more water could prevent kidney stones from coming back. Over 1,600 adults and children who had a kidney stone in the past used a smart water bottle to track their intake, with some getting financial rewards for meeting the…

This study tested whether digital tools like a smart water bottle, a fitness watch, and text reminders could help people with a history of kidney stones drink more water as their doctor recommended. 216 adults who had a kidney stone in the past 5 years and drank less than 2 liter…

Doctors often place a ureteral stent after flexible surgery to remove kidney stones, but stents cause discomfort and may need a second procedure for removal. This study at Ain Shams University follows 140 adults with upper urinary tract stones up to 2.5 cm who have the surgery wi…

This study tested whether wearing virtual reality glasses during a common kidney stone treatment (ESWL) can lower patients' pain, anxiety, and improve comfort. Seventy adults undergoing the procedure for the first time took part. Researchers measured pain, anxiety, and comfort le…

This study tested whether a structured education session led by a nurse could lower anxiety and improve quality of life in 188 adults having their first shock wave lithotripsy for kidney stones. The education covered what to expect during the procedure, pain management, and recov…

This study tests whether a device called TENS (transcutaneous electrical nerve stimulation) can reduce pain, nausea, and vomiting after kidney stone surgery. Researchers will compare 36 patients who receive TENS with 36 who do not, tracking their recovery over the first 24 hours.…

This study tested whether using a stress ball during a non-surgical kidney stone treatment (ESWL) can reduce pain and anxiety. 64 adults having their first ESWL session participated. The stress ball is a simple, cheap tool that distracts the mind. Researchers measured pain, anxie…

This study compared two FDA-approved lasers used to break up kidney stones during surgery: the newer SOLTIVE Thulium Fiber Laser and the standard Ho:YAG laser. About 100 adults with a single stone smaller than 2 cm took part. Researchers measured how well each laser cleared stone…

This study tested a new technique to hold kidney stones in place during a minimally invasive surgery called mini-PCNL. The goal was to make the stone-breaking step faster and reduce leftover fragments. 45 adults with stones smaller than 4 cm took part. The study measured how long…

This study tested two different tools used during surgery to remove kidney stones up to 20 mm. One is a traditional tube that lets fluid and stone pieces flow out, and the other is a newer tube that uses suction to actively pull out stone fragments. The goal was to see which tool…

This study looked at 180 children aged 6-12 with hard kidney stones (1-2 cm). It compared two procedures: mini-PCNL (a small back incision) and flexible ureteroscopy (a tube through the urinary tract). The goal was to see which method removes stones more completely and safely. Re…

This study tested three different methods for removing kidney stones up to 2 centimeters in size. All methods use a flexible scope through the urinary tract, but one uses a traditional tube, another uses a tube with suction, and the third uses no tube at all. Researchers measured…

This study looked at whether taking a type of medication called alpha-blockers (tamsulosin or silodosin) before a specific kidney stone surgery (RIRS) makes it easier for doctors to insert a needed tube and reduces damage to the tube that carries urine from the kidney to the blad…

This study looked at whether leaving out the urinary catheter after ureteroscopic kidney stone surgery reduces pain and urgency. 180 adults aged 18-70 with normal kidney function took part. Researchers compared pain scores and urgency between those with and without a catheter to …

This study tested whether giving a single dose of pregabalin (Lyrica) before ureteroscopy—a surgery for kidney stones that often leaves a temporary stent in the ureter—can reduce pain and the need for opioid painkillers afterward. 118 adults were randomly assigned to receive eith…

This study tested a procedure called an erector spinae plane block to see if it could help with pain from kidney stones. Only 5 people took part, all of whom had already received one pain medication in the emergency room. The results are very early and not enough to draw firm con…

This study compared two common surgeries for removing large kidney stones stuck in the upper ureter: ureteroscopic lithotripsy (URS) and laparoscopic ureterolithotomy (LU). Fifty-six adults with a single stone between 10-20 mm were randomly assigned to one procedure. Researchers …

This study tests whether a special ultrasound technique called shear wave elastography can predict how well kidney stone treatment (ESWL) will work in children. Currently, doctors use CT scans to estimate stone hardness, but these expose children to radiation. The study will incl…

This large observational study will follow 4,000 adults undergoing percutaneous nephrolithotomy (PCNL) for kidney stones across many international centers. Researchers will track which surgical techniques are used, how well they clear stones, and what complications occur. The goa…

This completed study compared two devices used to place a breathing tube during kidney stone surgery: a videolaryngoscope and a VideoLMA. Researchers measured how long each took and how often they worked on the first try. The trial involved 100 adults and aimed to find which devi…

This study tested a system called sipIT that uses a smart water bottle and phone app to track fluid intake and send reminders. The goal was to see if it helps kidney stone patients form a habit of drinking more fluids. 172 adults with a recent kidney stone diagnosis used the syst…

This study looked at 210 adults who had kidney stone surgery (RIRS) to see if placing a stent before the procedure helped clear stones completely and reduced the need for a second surgery. Researchers compared how long the stent was left in before surgery. The goal is to find the…

This study looked at 61 adults with kidney stones to see if stone size and density could predict how much laser energy is needed during a procedure called thulium fiber laser lithotripsy. Researchers used CT scans before surgery to measure stone volume and density, then tracked t…

This study looked at whether a common step in kidney stone surgery—placing a tube from the bladder to the kidney—can be skipped. 140 adults with large kidney stones were randomly assigned to get the standard surgery or a version without the tube. The goal was to see if the simple…

This study reviewed 500 patients who had a common kidney stone surgery (PCNL) done by one surgeon. The goal was to find out how often significant bleeding and blood transfusions actually happen. The results could help doctors give patients more accurate information about the risk…

This study involved 50 adults with kidney stones who received shock wave therapy (ESWL) to break up stones. Researchers wanted to see if waiting longer between treatment sessions caused less kidney damage. They measured two proteins in urine (NGAL and KIM-1) that signal kidney in…

This study tested whether a 3D-CT scan can better predict if a patient with a 1-2 cm kidney stone will need a stent after shockwave treatment, compared to the usual formula. Fifty-six adults with a single stone were treated without a stent first, and their stone volume was measur…

This completed trial compared two surgical procedures for removing kidney stones: standard PCNL and mini-PCNL. The study enrolled 18 adults with stones 10-20mm and measured blood loss, complications, and recovery time. The goal was to see if the smaller incision approach offers a…

This study looked at 70 adults having kidney stone surgery to see if the amount of air given by the breathing machine (tidal volume) affects how the surgery goes. Researchers compared low versus standard tidal volume settings to see if they changed surgery time, stone removal rat…

This study tested two ways of giving anesthesia gas (sevoflurane) during kidney stone surgery. One method used a very low gas flow (minimal-flow), the other a slightly higher flow (low-flow). In 62 adults, the minimal-flow approach used less anesthesia drug while keeping patients…

This study examined 346 adults who had kidney stone surgery to see if changes in their urine white blood cells and nitrite levels before the operation could predict serious infections like fever or sepsis afterward. The goal was to find a faster, simpler way to identify high-risk…

This study followed 94 adults who have both recurrent urinary tract infections and kidney stones that are not blocking the kidney. Researchers wanted to see if surgically removing these stones reduces the number of future UTIs compared to just monitoring them. Patients chose with…