New citrate cocktail may dissolve tough kidney stones without surgery
NCT ID NCT07162974
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested a citrate mixture (citric acid, potassium bicarbonate, and sodium citrate) to dissolve coral-like urate kidney stones in 49 patients. The goal was to see if the treatment could shrink or eliminate stones, potentially avoiding surgery. Patients took a personalized dose to keep urine pH at 7.2, and doctors used CT scans to track stone size and density.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
citrate mixture (anhydrous citric acid, potassium bicarbonate, sodium citrate)
What this could lead to
If successful, this approach could offer a non-surgical way to dissolve certain kidney stones, reducing the need for invasive procedures.
What could go wrong
This was a small, single-group study with 49 participants and no comparison group. Results may not apply to all stone types or patients. The treatment requires careful pH monitoring and may not work for everyone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Moscow state university of medicine and dentistry named after A.I. Evdokimov
Moscow, 127473, Russia