New citrate cocktail may dissolve tough kidney stones without surgery

NCT ID NCT07162974

Completed Disease control Sponsor: Moscow State University of Medicine and Dentistry Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a citrate mixture (citric acid, potassium bicarbonate, and sodium citrate) to dissolve coral-like urate kidney stones in 49 patients. The goal was to see if the treatment could shrink or eliminate stones, potentially avoiding surgery. Patients took a personalized dose to keep urine pH at 7.2, and doctors used CT scans to track stone size and density.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: citrate mixture (anhydrous citric acid, potassium bicarbonate, sodium citrate)
What this could lead to: If successful, this approach could offer a non-surgical way to dissolve certain kidney stones, reducing the need for invasive procedures.
What could go wrong: This was a small, single-group study with 49 participants and no comparison group. Results may not apply to all stone types or patients. The treatment requires careful pH monitoring and may not work for everyone.

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Conditions

The condition(s) this trial relates to.

acute urate nephropathy urolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UROLITHIASIS

Contacts and locations

Locations

Moscow state university of medicine and dentistry named after A.I. Evdokimov

Moscow, 127473, Russia

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