UROLITHIASIS

This study tests whether using an antibiotic (gentamicin) in the irrigation fluid and a special suction tube during kidney stone surgery can lower the chance of fever, inflammation, or sepsis afterward. About 180 adults having this surgery will be randomly assigned to receive one…

This study tests whether giving people a live gut bacterium called Oxalobacter formigenes can lower the amount of oxalate in their urine. High urinary oxalate is a major risk factor for calcium oxalate kidney stones. Forty adults with a history of such stones who lack this bacter…

This study tests a new device called the CVAC system that uses suction during a scope procedure to remove kidney stones. It compares how well this works versus the usual method (laser and no suction) in 150 adults. The main goal is to see if the new tool leaves fewer stone fragme…

This study tests whether a herbal supplement called Neorenal Forte can help eliminate small leftover kidney stone fragments after laser surgery. About 120 adults with kidney stones will take either the supplement or a placebo for three months. The goal is to see if more people be…

This study looks at whether it's safe to skip antibiotics before a specific type of kidney stone surgery in patients at low risk for infection. The surgery uses a special suction tool to remove stones. Researchers will compare infection rates between those who get antibiotics and…

This study compares two versions of a shockwave machine for breaking kidney stones: one with stone tracking and one without. About 126 adults with a single kidney stone (6-15 mm) will be randomly assigned to either group. The goal is to see if the tracking feature helps more peop…

This study compares a new type of ureteral stent (ComfiJ) with a standard Double-J stent in 150 adults who need a short-term stent after kidney stone surgery. The goal is to see if the ComfiJ stent causes fewer urinary symptoms, like pain or urgency, two weeks after surgery. Part…

This study compares L-citrulline, an amino acid, to tamsulosin, a standard drug, for helping adults pass kidney stones. 120 people with a single stone in the lower ureter will take one of the two treatments for up to 4 weeks. The main goal is to see which treatment leads to faste…

This study compares a nasal spray form of ketorolac (Sprix) to oral diclofenac pills for managing pain from ureteral stents placed after kidney stone surgery. Researchers will enroll 80 adults to see if the nasal spray provides faster pain relief and reduces unplanned doctor visi…

This study compares two common surgeries for removing kidney stones: mini-PCNL (a small incision in the back) and flexible ureteroscopy with a special suction tube. About 80 adults with kidney stones between 1 and 3 cm will be randomly assigned to one procedure. The main goal is …

This study tests whether adding ear acupressure to standard painkillers helps adults with kidney stone pain feel better faster. 116 participants will receive either real ear acupressure or a sham procedure alongside an NSAID injection in the emergency room. Pain levels will be tr…

This study tests a modified double-J ureteral stent with a thinner loop at the bladder end, designed to reduce common side effects like pain, blood in urine, and discomfort. About 40 adults with kidney or ureteral stones will receive either the new stent or a standard one. Resear…

This large observational study will follow 4,000 adults undergoing percutaneous nephrolithotomy (PCNL) for kidney stones across many international centers. Researchers will track which surgical techniques are used, how well they clear stones, and what complications occur. The goa…

This study aims to find out if people who get calcium oxalate kidney stones produce more oxalate in their bodies than healthy people. Researchers will compare 80 adults—some with a history of stones and some without—after they eat a special low-oxalate diet and take small amounts…

This study aims to find out if people who get calcium oxalate kidney stones absorb more oxalate from food than healthy people. Researchers will compare stone formers and healthy volunteers by having them eat special diets and measuring oxalate in urine, blood, and stool. The goal…