Trigeminal autonomic cephalalgia

This pilot study tested whether rimegepant (Nurtec ODT), a drug already used for migraines, could help prevent cluster headaches. Twenty adults with recurrent cluster headaches took the drug every other day for a week. Researchers measured changes in weekly attack frequency and p…

This study tested whether a single 2-hour infusion of ketamine combined with magnesium sulfate can reduce the number of daily attacks in people with refractory chronic cluster headache—a rare and severe headache disorder. 93 adults who had at least 2 attacks per day and did not r…

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…

This study tested a personalized psychological intervention for 5 adolescents aged 12-18 with recurrent headaches. Researchers used smartphone surveys to track each teen's unique headache triggers and coping patterns, then delivered 4-5 weekly online therapy sessions based on tha…

This study looked at 20 people with hard-to-treat chronic cluster headache who were already receiving occipital nerve stimulation. Researchers used brain scans to see how the stimulation changes brain activity. The goal was to understand how the treatment works, not to test if it…

This study looked at how osteopathic manual therapy (OMT) changes the brain in people with migraines, tension, or cluster headaches. Researchers used MRI scans to see if OMT affects brain structure and activity. The goal was to understand how OMT reduces pain and disability, not …

This small study looked at how occipital nerve stimulation (ONS) changes the way people with chronic migraine or cluster headache feel pain. Researchers used special tests and questionnaires to measure pain markers before and after ONS, and compared results to people having non-p…

This study surveyed 2,487 people diagnosed with cluster headache about how well their current treatments work and what they think about new treatment options. Participants filled out a single online questionnaire. The goal was to gather patient views, not to test any new drug or …

This study looked at whether measuring a protein called S100B in the blood can help emergency doctors tell the difference between primary headaches (like migraines) and secondary headaches (caused by something serious like a bleed or infection). Researchers enrolled 81 adults wit…

This study looked at how headaches impact sleep, pain sensitivity, and emotional well-being in 132 adults aged 18-65. Researchers measured sleep quality, central sensitization (a heightened pain state), and levels of depression, anxiety, and stress using standard questionnaires. …