Sudden cardiac arrest

This trial tests a special implantable cardioverter-defibrillator (ICD) that uses a single lead to sense both heart chambers, aiming to detect atrial fibrillation and other arrhythmias early. It includes 56 people who need a single-chamber ICD and are in normal sinus rhythm at th…

This study tested whether using a smartphone app to alert nearby volunteers (called 'heart runners') to bring an automated external defibrillator (AED) to a suspected cardiac arrest can improve survival. Over 2,000 emergency calls were randomly assigned to either activate these v…

This study tested a wearable defibrillator patch (the Jewel) in 18 adults who were already scheduled for a heart procedure. The patch was used to deliver a shock to stop dangerous heart rhythms that could lead to sudden cardiac arrest. The goal was to see how often the patch coul…

This study tested a wearable defibrillator called the Jewel P-WCD in 322 adults at high risk for sudden cardiac arrest. The device is designed to automatically deliver a shock to restore normal heart rhythm if a dangerous heart rhythm occurs. The main goals were to see how often …

This study tested whether permanent pacemakers can be safely implanted using only ultrasound (transthoracic echocardiography) instead of traditional X-ray guidance. Thirty-one adults with arrhythmias who needed a pacemaker took part. The goal was to see if the procedure could be …

This study tested a new type of wire (lead) for implantable heart devices that deliver shocks to stop dangerous fast heart rhythms. Researchers checked how safe and effective the lead was in 998 people who needed a defibrillator or heart failure device. The lead was placed in a s…

This study tested whether a special type of dialysis (high-permeability hemodialysis) could help people in shock after being revived from cardiac arrest. The idea was to filter out inflammatory substances from the blood to improve blood pressure and reduce the need for strong med…

This trial tests whether a wearable patch called MEMO Patch V2 can detect heart rhythm disorders (arrhythmias) more effectively than the standard 24-hour Holter monitor. Adults with symptoms like palpitations or dizziness, or those who have had a stroke of unknown cause, will wea…

This study investigates whether an Apple Watch can accurately detect heart rhythm problems (arrhythmias) in children aged 6 to 21 who are already scheduled for standard heart monitoring. Researchers will compare the watch's ECG and heart rate readings to those from conventional c…

This study tested a new non-invasive tool called ECG-Imaging that uses many electrodes on the body to create a 3D map of the heart's electrical activity. The goal was to see if it can more accurately locate the source of heart rhythm problems compared to a standard ECG. 362 parti…

This study looked at whether a 12-week virtual exercise program could help women with cardiac implantable electronic devices (CIEDs) improve their physical fitness, quality of life, and mental health. Twenty women took part, doing either high-intensity interval training (HIIT) or…

This study aims to establish national reference levels for radiation exposure during X-ray guided procedures to correct heart rhythm disorders, such as pacemaker insertions and ablations. Researchers will collect radiation dose data from over 4,000 adult patients undergoing these…

This study tests whether wearing a heart monitor for 14 days can detect dangerous heart rhythms in people with mitral valve prolapse (a common heart valve condition) better than the usual 24-hour test. About 60 adults with MVP will wear a patch monitor for two weeks. The goal is …

This study tests whether a single training session can improve police officers' ability to recognize agonal breathing — an abnormal gasping pattern that can be mistaken for normal breathing during cardiac arrest. Over 3,400 officers in New Taipei City will take a 20-minute CPR re…

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This study looked at whether a special mapping tool called vMap can help doctors perform heart ablations more efficiently for people with irregular heartbeats (arrhythmias). Researchers tracked 112 patients to see if using vMap reduced procedure time and improved success rates. T…

This study examines how often patients and their relatives develop post-traumatic stress disorder (PTSD) after a sudden cardiac arrest. Researchers interviewed 45 people (20 survivors and 20 relatives) within a week of the event and again at 3 months using standard questionnaires…

This study tested whether using a video call (telemedicine) to guide bystanders in CPR is better than standard phone-only instructions. Researchers studied 108 adults with suspected cardiac arrest in Bangkok, Thailand. The goal was to see if video help leads to more people receiv…

This study looked at whether giving CPR instructions over the phone before help arrives increases the number of bystanders who perform CPR. Researchers tracked 274 adults who had a cardiac arrest outside the hospital. The goal was to see if simple instructions could save more liv…

This study looked at 537 people with myotonic dystrophy type 1 to understand their risk of serious heart rhythm problems, including sudden cardiac arrest. Researchers tracked participants for two years to see how often these events happened and what factors might predict them. Th…

This completed registry study followed over 5,000 people with heart rhythm disorders who received Abbott devices during standard procedures. The goal was to collect real-world data on safety and how well the devices work. No new treatments were tested; instead, the study observed…

This completed study looked at how the heart medication amiodarone behaves in children aged 0 to 18 with heart rhythm disorders. Researchers took blood samples from 57 children to measure drug levels and understand how the body processes it. The goal was to find the best dose for…

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This completed study looked at 110 people with cardiac amyloidosis, a condition where protein deposits build up in the heart. Researchers implanted a small device under the skin to continuously monitor heart rhythms for up to several years. The goal was to learn more about when a…

This study used a special brain imaging technique called near-infrared spectroscopy to see how the brain responds to pain and sounds while people are under general anesthesia. 44 healthy volunteers aged 12-30 were given either a painkiller (remifentanil) or a placebo. The goal wa…

This study looked at whether keeping a diary during intensive care can lower the risk of post-traumatic stress disorder (PTSD) in people who survived a sudden cardiac arrest and in their family members. About 173 patients and their relatives took part. Researchers measured PTSD s…

This study looked at 212 critically ill adults in one ICU to see if three blood test ratios could predict death. The ratios compare lactate, CRP, and procalcitonin to albumin levels. Researchers will check if these ratios are linked to survival and find cut-off values to help doc…

This study aimed to find out if certain genes make people more likely to die suddenly from a heart problem. Researchers looked at the DNA of 2,500 people to see if specific gene variations were linked to sudden cardiac death. No treatments or interventions were given; the goal wa…

This pilot study tested whether using two defibrillators early, instead of one, is feasible and safe for people whose hearts stop outside a hospital and don't respond to the first shock. Researchers enrolled 40 adults with a shockable heart rhythm. The goal was to see if emergenc…