Sudden cardiac arrest

This study tests whether an external abdominal tourniquet can temporarily block blood flow to the lower body during cardiac arrest, redirecting it to the brain and heart. Researchers will try it on 5 adults with non-traumatic cardiac arrest outside a hospital. The goal is to see …

This study looks at whether giving volunteer community responders a small, portable defibrillator (about the size of a chocolate bar) helps them treat people having a cardiac arrest outside the hospital. Around 1,000 volunteers in Singapore will carry the device for up to a year …

This study looks at whether giving a smaller dose of epinephrine (0.5 mg) during a heart attack outside the hospital helps more people survive with better brain function than the usual dose (1 mg). About 4,336 adults will be randomly assigned to receive either the low or standard…

This study looks at whether an implantable defibrillator (ICD) can reduce the risk of sudden cardiac death in people with non-ischemic dilated cardiomyopathy, a type of heart muscle disease not caused by blocked arteries. Researchers will use MRI scans to find heart scarring (fib…

This study tests a new CPR method called Bio-CPR, which synchronizes chest compressions with ventilation using a machine. Researchers will compare it to standard CPR in 408 adults who have a witnessed cardiac arrest. The goal is to see if this coordinated approach improves breath…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study aims to see if improving how emergency dispatchers handle calls and model their actions can speed up the detection of cardiac arrest and improve CPR quality. Researchers will study 4,000 people who experience cardiac arrest outside of a hospital. The goal is to learn i…

This study tests whether showing real-time visual feedback to EMS responders helps them deliver the right amount of air during simulated CPR. 80 rescuers will give breaths to a mannequin with and without feedback, using two different CPR strategies. The goal is to see if feedback…

This study will create a digital twin of the heart for 1,000 people who have had a heart attack. The goal is to see if this computer model can better predict who is at risk for sudden cardiac death compared to the current standard method. Participants will undergo a cardiac CT sc…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

This study looks at 421 people who are getting a heart device (ICD) to see if muscle health can help predict sudden cardiac death. Researchers will use AI to combine muscle scans, blood tests, and other data to build a risk prediction tool. No new treatments are tested—the goal i…

This study tests a machine learning device that uses heart tracings (ECG) to predict if a person will have another cardiac arrest after being revived. Researchers will first see if EMS providers find the device useful in simulated scenarios, then test its accuracy in 68 real pati…

This study looks at whether people with certain heart rhythm disorders also carry genetic variants linked to a rare muscle condition called non-dystrophic myotonia. Researchers will review medical records of 570 participants and invite some for a neurological exam and electromyog…