Short bowel syndrome

This phase 2 trial tests a new drug called HM15912 (sonefpeglutide) in 18 adults with short bowel syndrome who need intravenous nutrition. The study aims to see if the drug is safe and can help the gut absorb more nutrients, potentially reducing the need for IV support. Participa…

This study tests a device called the Eclipse XL1 that is placed inside the body to slowly stretch and lengthen the remaining small intestine in people with short bowel syndrome. The goal is to improve nutrition and reduce the need for intravenous feeding. The study will enroll 40…

This phase 3 trial tests glepaglutide, a synthetic hormone given as a twice-weekly injection, in 90 adults with short bowel syndrome who rely on IV nutrition. The goal is to see if the drug can safely reduce the amount of IV support needed. Participants will be randomly assigned …

This phase 3 trial is testing whether apraglutide, a synthetic version of a natural gut hormone, can help adults with short bowel syndrome and intestinal failure reduce their need for intravenous nutrition (parenteral support). Participants receive either apraglutide or a placebo…

This study tests a device called RELiZORB that pre-digests fat in tube feedings for children with short bowel syndrome who rely on IV nutrition. The goal is to see if it helps them absorb more nutrients and reduce their need for IV feeding. About 32 children aged 2 to 18 will use…

This phase IIa trial tests whether FT1, a lab-made version of a natural gut hormone, is safe and helps reduce fluid loss in adults with short bowel syndrome. Participants receive weekly injections of FT1 or a placebo for five weeks. The study measures changes in stool weight and …

This trial tests whether injections of recombinant human growth hormone can reduce the amount of intravenous (IV) nutrition needed by adults with short bowel syndrome. About 100 participants who rely on IV nutrition will receive the hormone for 4 weeks, and researchers will measu…

This phase 2 trial tests crofelemer, a plant-based oral powder, in 18 adults with short bowel syndrome and intestinal failure who rely on IV nutrition. Participants receive either a low dose, a higher dose, or a placebo for 24 weeks. The goal is to see if crofelemer safely reduce…

This study looks at whether a drug called teduglutide can help children aged 1 to 17 with short bowel syndrome reduce the amount of nutrition they get through a vein. The study will review past medical records and collect new data from about 12 children in China. The goal is to s…

This study tests a drug called PJ009 in people aged 14 and older with short bowel syndrome who rely on IV nutrition. The goal is to see if daily shots can safely reduce the amount of IV nutrition needed. Participants will receive either PJ009 or a placebo for 24 weeks, then all w…

This study is testing an upgraded amino acid-based nutritional supplement for 30 children and adults who have severe gut problems like inflammatory bowel disease, short bowel syndrome, or severe allergies. Participants will use the supplement as part of their diet for 28 days. Re…

This trial is developing an AI-powered device that listens to children's heart, breath, and bowel sounds to identify signs of common diseases like congenital heart disease, bronchopneumonia, and abdominal issues. It will involve 30,000 children aged 0-18, some with these conditio…

This observational study will follow 50 adults and children who are starting long-term parenteral nutrition (IV nutrition) to measure the buildup of advanced glycation end-products (AGEs) in their skin. AGEs are harmful compounds that form when sugar binds with proteins, and they…

This study measures how many calories people burn at rest, comparing healthy adults to those with intestinal failure (a condition where the gut cannot absorb enough nutrients). Researchers will also look at body composition and inflammation markers. The goal is to find out if ene…

This study investigates how well children with short bowel syndrome tolerate dietary fiber from green bean puree compared to children without the condition. Researchers will track digestive symptoms and changes in gut bacteria to understand if fiber can be safely introduced into …

This study tracks the quality of life of 750 children with intestinal failure across North America. Researchers will use surveys to measure physical, emotional, and social well-being, and look at how medical and family factors affect these scores. The goal is to identify what hel…

This study is creating a faster quality-of-life tool for people with short bowel syndrome, who often need long-term nutrition support. Researchers will compare a new simple 'disk' questionnaire to a longer existing one in 100 adults. The goal is to make regular check-ins easier f…

This study looks at why children with short bowel syndrome (a rare condition where part of the intestine is missing) respond differently to the drug teduglutide. Researchers will grow tiny, lab-made versions of the children's intestines (called organoids) from tissue samples take…

This study uses a survey to see how well patients and doctors understand the risks and required checkups for the drug GATTEX, used to treat Short Bowel Syndrome. About 600 people—adults who have taken GATTEX in the last 60 days and their healthcare providers—will answer true/fals…