Can a weekly injection ease the burden of short bowel syndrome?

NCT ID NCT07742735

Recruiting now Disease control Sponsor: VectivBio AG Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This phase 3 trial is testing whether apraglutide, a synthetic version of a natural gut hormone, can help adults with short bowel syndrome and intestinal failure reduce their need for intravenous nutrition (parenteral support). Participants receive either apraglutide or a placebo as a weekly injection for 24 weeks. The main goal is to see if the drug can lower the weekly volume of parenteral support needed, which could improve quality of life and reduce complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: apraglutide (a synthetic GLP-2 analogue given as a weekly injection)
What this could lead to: If successful, apraglutide could become a treatment that helps people with short bowel syndrome reduce their dependence on intravenous nutrition, improving daily life and reducing complications.
What could go wrong: This is a phase 3 trial, but results are not guaranteed. The drug may not work for everyone, and side effects are possible. The study is relatively small (124 participants), so findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Intestinal Failure short bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SBS ASSOCIATED WITH INTESTINAL FAILURE (SBS-IF) SHORT BOWEL SYNDROME (SBS)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aberdeen Royal Infirmary
NOT_YET_RECRUITING

Aberdeen, Scotland, AB25 2ZN, United Kingdom
Albany Medical Center
NOT_YET_RECRUITING

Albany, New York, 12208, United States
Allende Sanatorium
NOT_YET_RECRUITING

Córdoba, X5000JHQ, Argentina
Asan Medical Center
NOT_YET_RECRUITING

Seoul, 05505, South Korea
Asklepios Clinic St. Georg
NOT_YET_RECRUITING

Hamburg, Free and Hanseatic City of Hamburg, 20099, Germany
Austin Hospital
NOT_YET_RECRUITING

Heidelberg, VIC 3084, Australia
Beaujon Hospital - APHP
NOT_YET_RECRUITING

Clichy, 92110, France
Bordeaux University Hospital Center - Haut-Leveque Hospital, Haut-Leveque Hospital
NOT_YET_RECRUITING

Pessac, 33600, France
Buenos Aires Italian Hospital
NOT_YET_RECRUITING

Buenos Aires, C1199ABB, Argentina
CDC Medical Center
NOT_YET_RECRUITING

Luján, M5505, Argentina
CHUM - University of Montreal Hospital Centre
NOT_YET_RECRUITING

Montreal, Quebec, H2X 3E4, Canada
Careggi University Hospital
NOT_YET_RECRUITING

Florence, 50134, Italy
Caxias Do Sul University / Clinical Research For Multicenter Studies Institute
NOT_YET_RECRUITING

Caxias do Sul, Rio Grande do Sul, 95070-560, Brazil
Chaim Sheba Medical Center, Institute of Gastrointestinal Diseases, Nutrition Unit
NOT_YET_RECRUITING

Tel Litwinsky, 5262000, Israel
Charite - University Hospital Berlin
NOT_YET_RECRUITING

Berlin, State of Berlin, 10117, Germany
Cleveland Clinic - Cleveland
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Florida
NOT_YET_RECRUITING

Weston, Florida, 33331, United States
Denver Health Medical Center
NOT_YET_RECRUITING

Denver, Colorado, 80204, United States
Duke University Medical Center
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Far Eastern Memorial Hospital
NOT_YET_RECRUITING

New Taipei City, 220, Taiwan
Fiona Stanley Hospital, Harry Perkins Medical Research Institute
NOT_YET_RECRUITING

Perth, WA 6150, Australia
GI Pros
RECRUITING

Naples, Florida, 34102, United States
Gastro Health - Clifton
NOT_YET_RECRUITING

Cincinnati, Ohio, 45219, United States
General University Hospital in Prague
NOT_YET_RECRUITING

Prague, 128 08, Czechia
Henry Ford Medical Center - Columbus
NOT_YET_RECRUITING

Novi, Michigan, 48377, United States
Hospices Civils de Lyon - Lyon Sud
NOT_YET_RECRUITING

Lyon, 69310, France
Hospital Sao Marcos
NOT_YET_RECRUITING

Teresina, Piauí, 64001-280, Brazil
Hospital of the University of Pennsylvania
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
IRCCS University Hospital of Bologna, Polyclinic S. Orsola-Malpighi
NOT_YET_RECRUITING

Bologna, 40138, Italy
Jerzy Gromkowski Provincial Specialist Hospital
NOT_YET_RECRUITING

Wroclaw, 51-149, Poland
Kagawa University Hospital
NOT_YET_RECRUITING

Kagawa, 761-0793, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
NOT_YET_RECRUITING

Kaohsiung City, 807377, Taiwan
King Chulalongkorn Memorial Hospital
NOT_YET_RECRUITING

Bangkok, 10330, Thailand
Loyola University Medical Center
NOT_YET_RECRUITING

Maywood, Illinois, 60153, United States
Maggiore Polyclinic Hospital, Foundation IRCCS Ca' Granda
NOT_YET_RECRUITING

Milan, 20122, Italy
Maharat Nakhon Ratchasima Hospital
NOT_YET_RECRUITING

Nakhon Ratchasima, 30000, Thailand
MedStar Georgetown University Hospital
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Medrise Sp. z o.o. (LLC)
NOT_YET_RECRUITING

Lublin, 20-582, Poland
Meir Medical Center, Institute of Gastroenterology and Liver Diseases
NOT_YET_RECRUITING

Kfar Saba, 4428164, Israel
Mount Sinai Medical Center, RMTI - Intestinal Transplantation & Rehabilitation
NOT_YET_RECRUITING

New York, New York, 10029, United States
Nancy Regional University Hospital Center - Brabois Hospital
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, 54500, France
Nantes University Hospital Center - Hotel Dieu Hospital
NOT_YET_RECRUITING

Nantes, 44000, France
Non-Public Healthcare Facility Stadmedica, Ambulatory Specialist Care
NOT_YET_RECRUITING

Bydgoszcz, 85-391, Poland
Northern Care Alliance NHS Foundation Trust, Intestinal Failure Unit
NOT_YET_RECRUITING

Salford, M6 8HD, United Kingdom
OSU Wexner Medical Center
NOT_YET_RECRUITING

Columbus, Ohio, 43210, United States
Order Hospital Linz Ltd. - Hospital of Sisters of Mercy, Department of Surgery
NOT_YET_RECRUITING

Linz, Upper Austria, 4010, Austria
Pacific Gastroenterology Associates
NOT_YET_RECRUITING

Vancouver, British Columbia, V6Z 2K5, Canada
Phramongkutklao Hospital
NOT_YET_RECRUITING

Bangkok, 10400, Thailand
Polyclinic San Matteo, IRCCS
NOT_YET_RECRUITING

Pavia, Lombardy, 27100, Italy
Pontifical University Of Rio Grande Do Sul (PUCRS) - St. Luke Hospital
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Porto Alegre Clinical Hospital (HCPA)
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
QualiVida Higienopolis - Hapvida NotreDame
NOT_YET_RECRUITING

São Paulo, São Paulo, 01233-000, Brazil
Radboud University Medical Center (Radboudumc)
NOT_YET_RECRUITING

Nijmegen, 6525GA, Netherlands
Ramathibodi Hospital
NOT_YET_RECRUITING

Bangkok, 10400, Thailand
Rambam Health Care Campus, Institute of Gastroenterology, Nutrition Clinic
NOT_YET_RECRUITING

Haifa, 3109601, Israel
Regional Medical School Foundation (CIP HB/FAMERP)
NOT_YET_RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Rigshospitalet - University Hospital Copenhagen
NOT_YET_RECRUITING

Copenhagen, DK-2100, Denmark
Ronald Reagan UCLA Medical Center, Center for the Health Sciences
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
Royal Brisbane and Women's Hospital, Gastroenterology and Hepatology
NOT_YET_RECRUITING

Herston, QLD 4029, Australia
Royal London Hospital
NOT_YET_RECRUITING

London, E1 1FR, United Kingdom
Saga-Ken Medical Centre Koseikan
NOT_YET_RECRUITING

Saga, Saga-ken, 840-8571, Japan
Samsung Medical Center
NOT_YET_RECRUITING

Seoul, 06351, South Korea
San Martin General La Plata Acute General Regional Hospital
NOT_YET_RECRUITING

La Plata, B1904CFU, Argentina
Semmelweis University, Department of Surgery, Transplantation and Gastroenterology
NOT_YET_RECRUITING

Budapest, H-1082, Hungary
Shaare Zedek Medical Center, Digestive Diseases Institute, Nutrition Clinic
NOT_YET_RECRUITING

Jerusalem, 9103102, Israel
Siriraj Hospital
NOT_YET_RECRUITING

Bangkok, 10700, Thailand
Songklanagarind Hospital
NOT_YET_RECRUITING

Hat Yai, 90110, Thailand
St Mark's Hospital
NOT_YET_RECRUITING

London, Middlesex, HA1 3UJ, United Kingdom
St Vincent's Hospital (Melbourne) Ltd
NOT_YET_RECRUITING

Fitzroy, VIC 3065, Australia
Taichung Veterans General Hospital
NOT_YET_RECRUITING

Taichung, 407219, Taiwan
The Catholic University of Korea, Seoul St. Mary's Hospital
NOT_YET_RECRUITING

Seoul, 06591, South Korea
The Tel Aviv Sourasky Medical Center, Institute of Gastrointestinal and Liver Diseases, Nutrition Clinic
NOT_YET_RECRUITING

Tel Aviv, 64239, Israel
University Duisburg-Essen, University Hospital Essen
NOT_YET_RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany
University Hospital Aachen AoeR
NOT_YET_RECRUITING

Aachen, Rhine-Westphalia, 52074, Germany
University Hospital Antwerp (UZA), Department of Gastroenterology and Hepatology
NOT_YET_RECRUITING

Edegem, 2650, Belgium
University Hospital Bonn
NOT_YET_RECRUITING

Bonn, North Rhine-Westphalia, 53127, Germany
University Hospital Brno, Clinic of Internal Medicine - Gastroenterology
NOT_YET_RECRUITING

Brno, 625 00, Czechia
University Hospital City of Health and Science of Turin - Hospital Molinette
NOT_YET_RECRUITING

Torino, 10126, Italy
University Hospital Erlangen
NOT_YET_RECRUITING

Erlangen, Bavaria, 91054, Germany
University Hospital Graz
NOT_YET_RECRUITING

Graz, 8010, Austria
University Hospital Heidelberg, Department of Endocrinology and Metabolism
NOT_YET_RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
University Hospital Hradec Kralove, 3rd Internal Clinic of Geronto-Metabolic
NOT_YET_RECRUITING

Hradec Králové, 500 05, Czechia
University Hospital Kralovske Vinohrady, Internal Clinic
NOT_YET_RECRUITING

Prague, 100 00, Czechia
University Hospital Muenster
NOT_YET_RECRUITING

Münster, North Rhine-Westphalia, 48149, Germany
University Hospital Virgen del Rocio (HUVR)
NOT_YET_RECRUITING

Seville, Andalusia, 41013, Spain
University Hospital of Padova
NOT_YET_RECRUITING

Padova, Veneto, 35128, Italy
University Hospitals Birmingham NHS Foundation Trust
NOT_YET_RECRUITING

Birmingham, B15 2TH, United Kingdom
University Hospitals Leuven, Campus Gasthuisberg, Department of Gastroenterology
NOT_YET_RECRUITING

Leuven, 3000, Belgium
University of Florida Health (UF Health)
NOT_YET_RECRUITING

Gainesville, Florida, 32610, United States
University of Szeged, Department of Internal Medicine- Western Site
NOT_YET_RECRUITING

Szeged, H-6725, Hungary
University of São Paulo Faculty of Medicine Clinics Hospital
NOT_YET_RECRUITING

São Paulo, São Paulo, 05403-000, Brazil
UofL Physicians - Colon & Rectal Surgery
NOT_YET_RECRUITING

Louisville, Kentucky, 40202, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Yokohama Municipal Citizen's Hospital
NOT_YET_RECRUITING

Yokohama, Kanagawa, 221-0855, Japan

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