Short bowel syndrome

This phase 3 trial tests a drug called teduglutide in 13 Chinese adults with short bowel syndrome who rely on IV nutrition. Participants get a daily injection for 24 weeks to see if it reduces their need for IV support. The study also checks safety and how the body processes the …

This phase 2 trial tests crofelemer, a plant-based oral powder, in 18 adults with short bowel syndrome and intestinal failure who rely on IV nutrition. Participants receive either a low dose, a higher dose, or a placebo for 24 weeks. The goal is to see if crofelemer safely reduce…

This study tests whether semaglutide, a drug used for diabetes, can improve intestinal barrier function in adults with short bowel syndrome who need intravenous nutrition. Twenty participants will receive either semaglutide or a placebo for 28 days. Researchers will measure blood…

This phase 2 trial tests a new drug called HM15912 (sonefpeglutide) in 18 adults with short bowel syndrome who need intravenous nutrition. The study aims to see if the drug is safe and can help the gut absorb more nutrients, potentially reducing the need for IV support. Participa…

This phase 3 trial tests glepaglutide, a synthetic hormone given as a twice-weekly injection, in 90 adults with short bowel syndrome who rely on IV nutrition. The goal is to see if the drug can safely reduce the amount of IV support needed. Participants will be randomly assigned …

This study looks at whether a drug called teduglutide can help children aged 1 to 17 with short bowel syndrome reduce the amount of nutrition they get through a vein. The study will review past medical records and collect new data from about 12 children in China. The goal is to s…

This study tests a drug called PJ009 in people aged 14 and older with short bowel syndrome who rely on IV nutrition. The goal is to see if daily shots can safely reduce the amount of IV nutrition needed. Participants will receive either PJ009 or a placebo for 24 weeks, then all w…

This study is testing an upgraded amino acid-based nutritional supplement for 30 children and adults who have severe gut problems like inflammatory bowel disease, short bowel syndrome, or severe allergies. Participants will use the supplement as part of their diet for 28 days. Re…

This study tests a device called RELiZORB that pre-digests fat in tube feedings for children with short bowel syndrome who rely on IV nutrition. The goal is to see if it helps them absorb more nutrients and reduce their need for IV feeding. About 32 children aged 2 to 18 will use…

This study tests a device called the Eclipse XL1 that is placed inside the body to slowly stretch and lengthen the remaining small intestine in people with short bowel syndrome. The goal is to improve nutrition and reduce the need for intravenous feeding. The study will enroll 40…

This early-phase pilot study is testing a drug called crofelemer in 6 adults with short bowel syndrome who have an ileostomy and need IV nutrition. The goal is to see if crofelemer can reduce ostomy output and the amount of IV support needed over 12 weeks. Participants take the d…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study tracks the quality of life of 750 children with intestinal failure across North America. Researchers will use surveys to measure physical, emotional, and social well-being, and look at how medical and family factors affect these scores. The goal is to identify what hel…

This study is creating a faster quality-of-life tool for people with short bowel syndrome, who often need long-term nutrition support. Researchers will compare a new simple 'disk' questionnaire to a longer existing one in 100 adults. The goal is to make regular check-ins easier f…

This study looks at why children with short bowel syndrome (a rare condition where part of the intestine is missing) respond differently to the drug teduglutide. Researchers will grow tiny, lab-made versions of the children's intestines (called organoids) from tissue samples take…

This study uses a survey to see how well patients and doctors understand the risks and required checkups for the drug GATTEX, used to treat Short Bowel Syndrome. About 600 people—adults who have taken GATTEX in the last 60 days and their healthcare providers—will answer true/fals…