Short bowel syndrome
MONDO:0015183Short bowel syndrome is an intestinal failure due to either a congenital defect, intestinal infarction or extensive surgical resection of the intestinal tract that results in a functional small intestine of less than 200cm in length and is characterized by diarrhea, nutrient malabsoption, bowel dilation and dysmobility.
Also known as: short gut syndrome
39 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsSub-types
Broader categories
-
New weekly shot shows promise for gut disorder patients
Disease control CompletedThis study tests the long-term safety and effectiveness of a weekly injection called glepaglutide in adults with short bowel syndrome, a condition where the body cannot absorb nutrients properly. Participants who completed a previous trial will receive the drug for about 2 years.…
Phase 3 • Sponsor: Zealand Pharma • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
-
New drug could help people with short bowel syndrome ditch IV nutrition
Disease control CompletedThis phase 3 trial tests the long-term safety of glepaglutide, a drug that mimics a natural gut hormone, in 145 adults with short bowel syndrome. The goal is to see if it can safely help the gut absorb more nutrients, potentially reducing the need for intravenous feeding. Partici…
Phase 3 • Sponsor: Zealand Pharma • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
-
New drug teduglutide monitored in 250 patients with short bowel syndrome
Disease control CompletedThis study follows 250 people in Japan with short bowel syndrome who are receiving teduglutide (Revestive) injections. Researchers will monitor side effects and how well the drug controls symptoms over 36 months. The goal is to see if teduglutide can safely reduce the need for in…
Sponsor: Takeda • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
-
Could a common diabetes drug help heal the gut in short bowel syndrome?
Disease control CompletedThis study tests whether semaglutide, a drug used for diabetes, can improve intestinal barrier function in adults with short bowel syndrome who need intravenous nutrition. Twenty participants will receive either semaglutide or a placebo for 28 days. Researchers will measure blood…
Sponsor: Jinling Hospital, China • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
-
Growth hormone shows promise for weaning kids off IV nutrition
Disease control CompletedThis study tested whether giving growth hormone to children with short bowel syndrome could help them reduce or stop needing IV nutrition. Fourteen children aged 3-18 who had been on IV nutrition for at least 3 years took part. The results will show if the hormone improves intest…
Phase 3 • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
-
Fish oil treatment shows promise for liver disease in kids on IV feeding
Disease control CompletedThis study tested a fish oil emulsion called Omegaven to treat liver disease in 36 children who depend on long-term intravenous (IV) nutrition. The goal was to lower bilirubin levels, a sign of liver damage. The treatment aims to control the disease and improve liver function.
Phase 3 • Sponsor: Kapiolani Medical Center For Women & Children • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
-
Could fiber be the key to better gut health for short bowel patients?
Disease control CompletedThis completed study looked at whether specific dietary fibers can improve nutrition and gut barrier function in people with short bowel syndrome. Ten adults with type II or III short bowel syndrome took dietary fiber, and researchers measured changes in blood and stool samples. …
Sponsor: Jinling Hospital, China • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
-
Daily injection could free kids from IV nutrition dependency
Disease control CompletedThis study tested a daily injection called teduglutide (Revestive) in 25 children aged 2 to 18 with short bowel syndrome who rely on IV nutrition. The goal was to see if the drug helps their intestines absorb more nutrients, so they can reduce or stop IV feedings. Researchers mea…
Phase 4 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 26, 2026 15:47 UTC
-
Scientists map gut hormone changes after bowel surgery
Knowledge-focused CompletedThis study looked at how removing parts of the small intestine affects gut hormone levels after eating. Researchers measured these hormones in 39 people with different types of bowel resection and compared them to healthy controls. The goal was to better understand digestion and …
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
-
Nighttime feeding vs daytime: which is better for sleep and sugar levels?
Knowledge-focused CompletedThis study looked at 20 adults with short bowel syndrome who rely on home parenteral nutrition. Researchers compared giving the nutrition overnight versus during the day to see if timing affects blood sugar levels and sleep quality. Participants wore glucose monitors and activity…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC