Short bowel syndrome
MONDO:0015183Short bowel syndrome is an intestinal failure due to either a congenital defect, intestinal infarction or extensive surgical resection of the intestinal tract that results in a functional small intestine of less than 200cm in length and is characterized by diarrhea, nutrient malabsoption, bowel dilation and dysmobility.
Also known as: short gut syndrome
39 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsSub-types
Broader categories
-
New drug could cut IV nutrition needs for short bowel patients
Disease control OngoingThis phase 3 trial tests a drug called teduglutide in 13 Chinese adults with short bowel syndrome who rely on IV nutrition. Participants get a daily injection for 24 weeks to see if it reduces their need for IV support. The study also checks safety and how the body processes the …
Phase 3 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
-
New drug shows promise for managing short bowel syndrome Long-Term
Disease control OngoingThis study looks at the long-term safety and effectiveness of a drug called glepaglutide in adults with short bowel syndrome (SBS), a condition where the body can't absorb enough nutrients from food. Participants who were already in earlier trials can continue treatment for up to…
Phase 3 • Sponsor: Zealand Pharma • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
-
New device could help kids with short bowel syndrome rely less on IV nutrition
Disease control By invitation onlyThis study looks at a device called RELiZORB that attaches to a feeding tube to pre-digest fat, making it easier for children with short bowel syndrome to absorb nutrients. The goal is to see if using it daily for 90 days can safely reduce or eliminate the need for intravenous (I…
Sponsor: Boston Children's Hospital • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
-
Could a Plant-Based drug cut IV nutrition needs for short bowel patients?
Symptom relief OngoingThis early-phase pilot study is testing a drug called crofelemer in 6 adults with short bowel syndrome who have an ileostomy and need IV nutrition. The goal is to see if crofelemer can reduce ostomy output and the amount of IV support needed over 12 weeks. Participants take the d…
Early phase 1 • Sponsor: Jessica Sosio • Aim: Symptom relief
Last updated Aug 21, 2026 00:00 UTC
-
New program aims to ease burden on families of kids with rare diseases
Symptom relief By invitation onlyThis study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …
Sponsor: Children's National Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
-
Green beans tested as first fiber food for short gut patients
Knowledge-focused By invitation onlyShort bowel syndrome is a rare condition where the bowel is too short to absorb enough nutrients. This study gives green bean puree to 60 adults with and without the condition to see if they can tolerate fiber. Researchers will track symptoms, weight, and changes in gut bacteria …
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
-
Global registry tracks Real-World safety of gut drug
Knowledge-focused OngoingThis registry follows about 1,800 people with short bowel syndrome (SBS) to see how safe and effective the drug teduglutide is over the long term in everyday medical practice. It includes both patients who take teduglutide and those who do not. The main goal is to monitor for col…
Sponsor: Shire • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC