Short bowel syndrome
MONDO:0015183Short bowel syndrome is an intestinal failure due to either a congenital defect, intestinal infarction or extensive surgical resection of the intestinal tract that results in a functional small intestine of less than 200cm in length and is characterized by diarrhea, nutrient malabsoption, bowel dilation and dysmobility.
Also known as: short gut syndrome
38 clinical trials for this condition and its sub-types.
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Broader categories
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New drug teduglutide monitored in 250 patients with short bowel syndrome
Disease control OngoingThis study follows 250 people in Japan with short bowel syndrome who are receiving teduglutide (Revestive) injections. Researchers will monitor side effects and how well the drug controls symptoms over 36 months. The goal is to see if teduglutide can safely reduce the need for in…
Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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New weekly shot shows promise for gut disorder patients
Disease control OngoingThis study tests the long-term safety and effectiveness of a weekly injection called glepaglutide in adults with short bowel syndrome, a condition where the body cannot absorb nutrients properly. Participants who completed a previous trial will receive the drug for about 2 years.…
Phase: PHASE3 • Sponsor: Zealand Pharma • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New drug shows promise for managing short bowel syndrome Long-Term
Disease control ENROLLING_BY_INVITATIONThis study looks at the long-term safety and effectiveness of a drug called glepaglutide in adults with short bowel syndrome (SBS), a condition where the body can't absorb enough nutrients from food. Participants who were already in earlier trials can continue treatment for up to…
Phase: PHASE3 • Sponsor: Zealand Pharma • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New drug could help people with short bowel syndrome ditch IV nutrition
Disease control OngoingThis phase 3 trial tests the long-term safety of glepaglutide, a drug that mimics a natural gut hormone, in 145 adults with short bowel syndrome. The goal is to see if it can safely help the gut absorb more nutrients, potentially reducing the need for intravenous feeding. Partici…
Phase: PHASE3 • Sponsor: Zealand Pharma • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New device could help kids with short bowel syndrome rely less on IV nutrition
Disease control ENROLLING_BY_INVITATIONThis study looks at a device called RELiZORB that attaches to a feeding tube to pre-digest fat, making it easier for children with short bowel syndrome to absorb nutrients. The goal is to see if using it daily for 90 days can safely reduce or eliminate the need for intravenous (I…
Sponsor: Boston Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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New program aims to ease burden on families of kids with rare diseases
Symptom relief ENROLLING_BY_INVITATIONThis study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …
Phase: NA • Sponsor: Children's National Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Massive data dive aims to improve GI care
Knowledge-focused ENROLLING_BY_INVITATIONThis study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Green beans tested as first fiber food for short gut patients
Knowledge-focused ENROLLING_BY_INVITATIONShort bowel syndrome is a rare condition where the bowel is too short to absorb enough nutrients. This study gives green bean puree to 60 adults with and without the condition to see if they can tolerate fiber. Researchers will track symptoms, weight, and changes in gut bacteria …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Global registry tracks Real-World safety of gut drug
Knowledge-focused OngoingThis registry follows about 1,800 people with short bowel syndrome (SBS) to see how safe and effective the drug teduglutide is over the long term in everyday medical practice. It includes both patients who take teduglutide and those who do not. The main goal is to monitor for col…
Sponsor: Shire • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC