Could a Plant-Based drug cut IV nutrition needs for short bowel patients?

NCT ID NCT06326645

Recruiting now Symptom relief Sponsor: Lindsey Russell, MD Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase pilot study is testing a drug called crofelemer in 6 adults with short bowel syndrome who have an ileostomy and need IV nutrition. The goal is to see if crofelemer can reduce ostomy output and the amount of IV support needed over 12 weeks. Participants take the drug as a powder three times daily, with a 4-week follow-up after treatment ends.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Crofelemer (oral powder)
What this could lead to: If it works, this could point toward a new way to reduce diarrhea and the need for IV nutrition in people with short bowel syndrome.
What could go wrong: This is a very early, small pilot study with only 6 people. It may not show clear benefit, and results may not apply to all patients. Side effects are not yet well understood.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SHORT BOWEL SYNDROME are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

short bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SHORT BOWEL SYNDROME

Contacts and locations

Locations

Cleveland Clinic Main Campus
RECRUITING

Cleveland, Ohio, 44106, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.