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Could a weekly shot free short bowel patients from IV bags?

NCT ID NCT07197944

Recruiting now Disease control Sponsor: Zealand Pharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This phase 3 trial tests glepaglutide, a synthetic hormone given as a twice-weekly injection, in 90 adults with short bowel syndrome who rely on IV nutrition. The goal is to see if the drug can safely reduce the amount of IV support needed. Participants will be randomly assigned to receive the drug or a placebo for several weeks, followed by an open-label period where everyone gets the drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
glepaglutide (a synthetic hormone injection)
What this could lead to
If successful, this could reduce or eliminate the need for daily IV nutrition in people with short bowel syndrome, improving quality of life.
What could go wrong
This is a phase 3 trial, but it's still experimental. The drug may not work for everyone, and side effects like injection site reactions or gastrointestinal issues are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Digestive System Diseases digestive system disorder intestinal disorder Intestinal Failure malabsorption syndrome Pathologic Processes Postoperative Complications short bowel syndrome syndromic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SHORT BOWEL SYNDROME

Contacts and locations

Locations

  • AP-HP - Hôpital Beaujon

    RECRUITING

    Clichy, 92118, France

  • Asklepios Klinik St. Georg

    RECRUITING

    Hamburg, Germany

  • Azienda Ospedale - Università Padova

    RECRUITING

    Padova, 35128, Italy

  • Charité - Universitätsmedizin Berlin

    RECRUITING

    Berlin, 10117, Germany

  • Dél-budai Centrumkórház Szent Imre Egyetemi Oktatókórház

    RECRUITING

    Budapest, 1115, Hungary

  • Eszak-Pesti Centrumkorhaz -Honvedkorhaz- Podmaniczky utcai telephely

    RECRUITING

    Budapest, 1062, Hungary

  • Eugastro Klinische Studien GmbH

    RECRUITING

    Leipzig, Saxony, 4103, Germany

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

    RECRUITING

    Milan, 20122, Italy

  • Fondazione Policlinico Universitario A. Gemelli IRCCS - PPDS

    RECRUITING

    Rome, Lazio, 00136, Italy

  • Helsingin Yliopistollinen Keskussairaala

    RECRUITING

    Helsinki, 00290, Finland

  • Hospital General Universitario Gregorio Marañon

    RECRUITING

    Madrid, Madrid, 28007, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, Madrid, 28041, Spain

  • Hospital Universitario Virgen del Rocio - PPDS

    RECRUITING

    Seville, Sevilla, 41013, Spain

  • Karolinska Universitetssjukhuset Solna

    RECRUITING

    Solna, 171 64, Sweden

  • Lied Transplant Center at Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68105, United States

  • New York Presbyterian Hospital-Columbia University Medical Center

    NOT_YET_RECRUITING

    New York, New York, 10032, United States

  • Oslo Universitetssykehus HF, Ullevål

    RECRUITING

    Oslo, 0450, Norway

  • Radboud Universitair Medisch Centrum

    RECRUITING

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Rigshospitalet-Blegdamsvej 9

    RECRUITING

    Copenhagen, 2100, Denmark

  • Sahlgrenska Universitets sjukhuset

    RECRUITING

    Gothenburg, 413 46, Sweden

  • Samodzielny Publiczny Szpitala Kliniczny im. Prof. Witolda Orlowskiego Centrum Medycznego Kształcenia Podyplomowego

    RECRUITING

    Warsaw, 00-416, Poland

  • Semmelweis Egyetem - Sebészeti, Transzplantációs és Gasztroenterológiai Klinika

    RECRUITING

    Budapest, 1082, Hungary

  • The University of Chicago Medicine

    RECRUITING

    Chicago, Illinois, 60637-1443, United States

  • Universitair Ziekenhuis (UZ) Leuven

    RECRUITING

    Leuven, 3000, Belgium

  • Universitätsklinikum AKH Wien

    RECRUITING

    Vienna, State of Vienna, 1090, Austria

  • Universitätsklinikum Aachen

    RECRUITING

    Aachen, 52074, Germany

  • Universitätsklinikum Bonn

    RECRUITING

    Bonn, 53127, Germany

  • Universitätsmedizin Rostock

    RECRUITING

    Rostock, Mecklenburg-Vorpommern, 18057, Germany

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Washington University Center for Advanced Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Wojewodzki Specjalistyczny Szpital im. M. Pirogowa w Lodzi

    RECRUITING

    Lodz, Lódzkie, 90-531, Poland

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