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New drug could help people with short bowel syndrome ditch IV nutrition

NCT ID NCT04775706

Recruiting now Disease control Sponsor: Hanmi Pharmaceutical Company Limited Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This phase 2 trial tests a new drug called HM15912 (sonefpeglutide) in 18 adults with short bowel syndrome who need intravenous nutrition. The study aims to see if the drug is safe and can help the gut absorb more nutrients, potentially reducing the need for IV support. Participants are randomly assigned to receive either the drug or a placebo, and neither they nor their doctors know which they get.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
HM15912 (sonefpeglutide)
What this could lead to
If it works, this could reduce or eliminate the need for intravenous nutrition in people with short bowel syndrome, improving their quality of life.
What could go wrong
This is a small, early-phase study with only 18 participants, so results may not apply to everyone. The drug may cause side effects or fail to show benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

short bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SHORT BOWEL SYNDROME

Contacts and locations

Locations

  • Asklepios Klinik St. Georg

    RECRUITING

    Hamburg, Free and Hanseatic City of Hamburg, 20099, Germany

  • Brigham & Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Central Middlesex Hospital

    RECRUITING

    London, NW10 7NS, United Kingdom

  • Centre Hospitalier Universitaire de Bordeaux

    RECRUITING

    Bordeaux, 33000, France

  • Centre Hospitalier Universitaire de Nice

    RECRUITING

    Nice, 06300, France

  • Hopital Beaujon

    RECRUITING

    Clichy, Clichy, 92110, France

  • Les Hospices Civils de Lyon

    RECRUITING

    Lyon, 69002, France

  • Rigshospitalet Department of Digestive Diseases, Transplantation and General Surgery Section for Intestinal Failure

    RECRUITING

    Copenhagen, 2100, Denmark

  • Salford Royal Hospital

    RECRUITING

    Salford, Greater Manchester, M6 8HD, United Kingdom

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Szpital Skawina sp. z o.o.

    RECRUITING

    Skawina, Lesser Poland Voivodeship, 32-050, Poland

  • The Cleveland Clinic Foundation

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • UZ Leuven

    RECRUITING

    Leuven, Vlaams Brabant, 3000, Belgium

  • Universitätsklinikum Tübingen

    RECRUITING

    Tübingen, Tübingen, 72076, Germany

  • Wojewodzki Specjalistyczny Szpital im. Mikołaja Pirogowa w Łodzi

    RECRUITING

    Lodz, Łódź Voivodeship, 90-531, Poland

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