Postmenopausal osteoporosis

This early-stage trial is testing whether taking blackcurrant extract capsules can slow bone loss in women who have gone through menopause. The study will measure changes in bone density and gut bacteria over 12 months in 159 women aged 45-70. The goal is to see if the berries wo…

This study looks at postmenopausal women with severe osteoporosis who have finished a course of either romosozumab or teriparatide. Researchers want to see which follow-up drug—zoledronate, denosumab, teriparatide, romosozumab, or abaloparatide—best maintains or improves bone den…

This study compares two treatment schedules for postmenopausal women with severe osteoporosis. One group gets romosozumab for 12 months then denosumab for 12 months. The other group cycles between the two drugs every 6 months for 2 years. Researchers will measure bone density and…

This study tests a new drug called SAL056 in postmenopausal women with osteoporosis. The goal is to find the safest and most effective dose. About 200 women aged 45 to 80 will receive different doses of the drug or a control treatment for around 10 weeks. The study focuses on sid…

This study aims to see how well two different FDA-approved medication regimens improve bone density in postmenopausal women with osteoporosis who are at high risk of fractures. About 50 women aged 45 and older will receive one of the two treatments for 12 months. The main goal is…

This study tests whether blocking a hormone called LH can improve bone health in menopausal women. 192 women with moderate-to-severe hot flashes will receive either a GnRH analog, estrogen, testosterone, or a placebo for 8 weeks. The goal is to find a safer alternative to estroge…

This study looks at women with postmenopausal osteoporosis who have been on denosumab for at least two years and are now stopping it. Stopping denosumab can cause a rapid bone loss and increase fracture risk. The trial compares two strategies using zoledronic acid infusions: one …

This study tests whether eating 5-6 prunes daily for 18 months can prevent the rapid bone loss that often happens during menopause. Researchers will compare bone density, inflammation, and gut health in 124 women aged 44-55 who either eat prunes or avoid them. If successful, this…

This study tests whether virtual reality exercise games can improve balance, reduce fall risk, and boost quality of life in postmenopausal women aged 50–75 with osteoporosis. Fifty participants will either do VR exercises or standard care. The goal is to see if fun, interactive g…

This study investigates whether a protein called lumican, found in the blood, can identify postmenopausal women who have fragile bones but normal bone density scans. About 100 women will have their bone density, muscle strength, and blood lumican levels measured. The goal is to s…

This study aims to find small molecules called microRNAs in the blood that can predict how well two osteoporosis drugs (romosozumab and abaloparatide) work in postmenopausal women. Researchers will measure bone density and blood markers over 12 months in 42 women. The goal is to …

This study looks at how different brain regions communicate in women with and without osteoporosis. Researchers will use MRI scans and blood tests to compare brain connectivity and bone markers in 60 postmenopausal women. The goal is to better understand the link between the brai…

This study looks at how the drug romosozumab affects bone-making cells in postmenopausal women with osteoporosis. Researchers will take small bone samples to count these cells early and late in treatment. The goal is to understand why the drug works, not to test a new treatment. …

This study looks at how mechanical loading, like standing or vibrating, affects spinal reflexes in postmenopausal women with and without osteoporosis. Researchers will measure nerve signals (H-reflex) under different loads to see if bone loss changes these responses. The goal is …