Postmenopausal osteoporosis

This study looks at whether adding the drug abaloparatide (Tymlos) to the standard treatment denosumab (Prolia) can improve bone density more than denosumab alone in postmenopausal women with osteoporosis. Seventy women who have already been on denosumab will either continue with…

This study aimed to see if romosozumab (Evenity) could improve bone density and muscle mass in postmenopausal women with osteoporosis undergoing lumbar spine surgery. Participants would have received monthly injections of romosozumab or weekly alendronate pills for 12 months. How…

This study looks at how teriparatide, a bone-building drug for severe osteoporosis, affects bone structure in postmenopausal women. Researchers will use a special scanner to see changes in bone thickness and tiny connecting rods at the wrist and ankle over 24 months. The goal is …

This study compares two FDA-approved medications, romosozumab and denosumab, for treating postmenopausal osteoporosis. Researchers will measure changes in hip bone density over 12 months in 50 women at high fracture risk. The goal is to see which drug works better to strengthen b…

This study tests whether a year of monthly injections of romosozumab, followed by an infusion of zoledronic acid, can improve bone density and prevent fractures in women aged 65 and older with osteoporosis who live in long-term care facilities. The goal is to find a treatment tha…

This early-stage trial is testing a new stem cell treatment called HMM910 in 9 postmenopausal women with osteoporosis who are at high risk of breaking a bone. The stem cells are given through an IV drip. The main goal is to see if the treatment is safe and tolerable, not yet to p…

This study tests an experimental drug called AGA2118 in postmenopausal women aged 55 to 80 who have low bone density but no history of fractures. The goal is to see if the drug can safely increase bone mineral density over 12 months compared to a placebo. About 379 women will par…

This study looks at whether giving zoledronate infusions can prevent bone loss in postmenopausal women who have stopped taking denosumab for osteoporosis. About 200 women who took denosumab for at least two years will receive zoledronate at different times. The goal is to find th…

This early-stage study tests a new injectable drug called LYN101 in 44 people. First, healthy volunteers get a single dose to check safety. Then, postmenopausal women with low bone mass get multiple doses to see how the drug affects bone turnover markers. The main goal is safety,…

This study was designed to see if a special bone scanner (bone mineral analyser) could predict how well osteoporotic women would respond to a zoledronic acid infusion. The plan was to measure bone texture and density before and one year after treatment. However, the study was wit…

This study tests whether a weekly dose of everolimus (a drug that targets aging pathways) and/or a fun exercise program called 'Football Fitness' can prevent the rapid bone loss that happens after menopause. 136 healthy women aged 45-60 will be assigned to one of four groups: exe…

This study explores whether a new type of resistance exercise is practical and safe for people with low bone mass, including those with osteopenia, osteoporosis, or sarcopenia. Over two months, one group performs progressive muscle-strengthening exercises while a control group co…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study was designed to test whether adding arm exercises to a standard osteoporosis medication could improve bone density in the wrist. It was planned for postmenopausal women at high fracture risk. However, the study was withdrawn before enrolling any participants, so no res…