Please sign in to follow a disease.
Neuromuscular disease
MONDO:0019056Any disease that impairs the functioning of the muscles, either directly, being pathologies of the voluntary muscle, or indirectly, being pathologies of nerves or neuromuscular junctions
Also known as: nerve and muscle disorder, neuromuscular disease
2353 clinical trials for this condition and its sub-types, 112 tagged with Neuromuscular disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Neuromuscular disease
-
Peripheral neuropathy 93 trials · 1,473 incl. sub-types
30 sub-types
- Hereditary peripheral neuropathy 6 trials · 479 incl. sub-types Sub-types →
- Neuralgia 238 trials · 384 incl. sub-types Sub-types →
- Nerve compression syndrome 24 trials · 207 incl. sub-types Sub-types →
- Diabetic neuropathy 182 trials · 193 incl. sub-types Sub-types →
- Chemotherapy-induced neuropathy 171 trials
- Polyneuropathy 32 trials · 133 incl. sub-types Sub-types →
- Mononeuropathy 4 trials · 112 incl. sub-types Sub-types →
- Acquired peripheral neuropathy 0 trials · 95 incl. sub-types Sub-types →
- Nerve plexus disorder 0 trials · 75 incl. sub-types Sub-types →
- Sensory peripheral neuropathy 4 trials · 58 incl. sub-types Sub-types →
- Traumatic neuropathy 55 trials
- Neuritis 18 trials · 29 incl. sub-types Sub-types →
- Peripheral nerve lesion 1 trial · 12 incl. sub-types Sub-types →
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Chronic idiopathic neuropathy 5 trials
- Axonal neuropathy 1 trial · 4 incl. sub-types Sub-types →
- Neuropathy, small fiber 4 trials
- Infectious neuropathy 2 trials
- Vasculitic neuropathy 2 trials
- Autoimmune neuropathy 1 trial
- Idiopathic small fibers neuropathy 1 trial
- Ischemic neuropathy 1 trial
- Motor peripheral neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Radiation-induced neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Sarcoid neuropathy 1 trial
- Neuropathy in cryoglobulinemia 0 trials
- Neuropathy in endocrine disorder 0 trials
- Paraproteinemia-associated neuropathy 0 trials
- Uremic neuropathy 0 trials
- Vitamin deficiency related neuropathy 0 trials
-
Hereditary neuromuscular disease 3 trials · 935 incl. sub-types
22 sub-types
- Hereditary peripheral neuropathy 6 trials · 479 incl. sub-types Sub-types →
- Muscular dystrophy 74 trials · 290 incl. sub-types Sub-types →
- Hereditary motor neuron disease 1 trial · 169 incl. sub-types Sub-types →
- Hereditary spastic paraplegia 27 trials · 33 incl. sub-types Sub-types →
- Benign paroxysmal positional vertigo 18 trials
- Meniere disease 16 trials Sub-types →
- RYR1-related myopathy 5 trials · 6 incl. sub-types Sub-types →
- Congenital myasthenic syndrome 6 trials Sub-types →
- Malignant hyperthermia of anesthesia 5 trials
- SCN4A-related channelopathy 1 trial · 2 incl. sub-types Sub-types →
- Early-onset myopathy with fatal cardiomyopathy 1 trial
- Andersen-Tawil syndrome 0 trials
- CNGB3-related retinopathy 0 trials Sub-types →
- KY-related neuromyopathy 0 trials Sub-types →
- Morimoto-Ryu-Malicdan neuromuscular syndrome 0 trials
- X-linked recessive mitochondrial myopathy 0 trials
- Myofibrillar myopathy 1 0 trials
- Myotonia congenita, autosomal dominant 0 trials
- Myotonia congenita, autosomal recessive 0 trials
- Neuromuscular disorder, congenital, with dysmorphic facies 0 trials
- Periodic paralysis with later-onset distal motor neuropathy 0 trials
- Vertigo, benign recurrent, 1 0 trials
-
Motor neuron disorder 70 trials · 510 incl. sub-types
4 sub-types
- Amyotrophic lateral sclerosis 331 trials · 345 incl. sub-types Sub-types →
- Hereditary motor neuron disease 1 trial · 169 incl. sub-types Sub-types →
- Acquired motor neuron disease 0 trials · 39 incl. sub-types Sub-types →
- Madras motor neuron disease 0 trials
-
Vestibular disorder 64 trials · 92 incl. sub-types
1 sub-type
- Peripheral vertigo 2 trials · 34 incl. sub-types Sub-types →
-
Muscular channelopathy 0 trials · 19 incl. sub-types
12 sub-types
- Thomsen and Becker disease 9 trials Sub-types →
- RYR1-related myopathy 5 trials · 6 incl. sub-types Sub-types →
- Malignant hyperthermia of anesthesia 5 trials
- SCN4A-related channelopathy 1 trial · 2 incl. sub-types Sub-types →
- Andersen-Tawil syndrome 0 trials
- CNGB3-related retinopathy 0 trials Sub-types →
- Isaac syndrome 0 trials
- Morvan syndrome 0 trials
- Neurological muscular channelopathy due to a genetic calcium channel defect 0 trials
- Neurological muscular channelopathy due to a genetic chloride channel defect 0 trials
- Neurological muscular channelopathy due to a genetic potassium channel defect 0 trials
- Neurological muscular channelopathy due to a genetic sodium channel defect 0 trials
-
Atrophic muscular disease 7 trials
-
Neuromuscular junction disease 1 trial · 7 incl. sub-types
1 sub-type
-
Akinetopsia 0 trials
Most studied deeper sub-types
-
Can a muscle-boosting antibody help people with spinal muscular atrophy over the long haul?
Disease control OngoingThis trial tests the long-term safety and effectiveness of apitegromab, an investigational antibody that blocks myostatin, a protein that limits muscle growth. People with type 2 or type 3 spinal muscular atrophy who completed earlier apitegromab studies can join. Researchers wil…
Phase 3 • Sponsor: Scholar Rock, Inc. • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
-
Heart cell therapy shows promise for duchenne MD in major trial
Disease control OngoingThis Phase 3 trial tests a cell therapy called deramiocel (CAP-1002) in 106 boys and young men with Duchenne muscular dystrophy. Participants receive either the cell therapy or a placebo every 3 months for a year, then all can receive the therapy for another year. The goal is to …
Phase 3 • Sponsor: Capricor Inc. • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
-
New hope for muscle disease: experimental drug VX-670 enters human trials
Disease control OngoingThis early-stage trial tests the safety and tolerability of a new drug called VX-670 in 52 adults with myotonic dystrophy type 1 (DM1), a genetic condition that causes muscle weakness and other problems. Participants receive either VX-670 or a placebo, and researchers will monito…
Phase 1/2 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
-
One-Patient trial hopes to fix rare nerve disease at its genetic root
Disease control OngoingThis study tests a custom-made drug (VCA-894A) in a single person with a rare genetic nerve disease called CMT2S. The drug is designed to correct a specific genetic error and restore a missing protein. The main goals are to check if the treatment is safe and if it can improve mus…
Phase 1/2 • Sponsor: Vanda Pharmaceuticals • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
-
Vertex tests long-term safety of VX-670 for muscle disease
Disease control By invitation onlyThis study tests the long-term safety and effectiveness of an experimental drug called VX-670 in adults with myotonic dystrophy type 1 (DM1). Participants who completed a previous VX-670 study can join. The drug is given through a vein, and researchers will monitor side effects a…
Phase 2 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
-
New drug shows promise for SMA patients in major trial
Disease control OngoingThis study tests whether adding taldefgrobep alfa to standard SMA treatments can improve muscle function in people with spinal muscular atrophy (SMA). About 269 participants, both walkers and non-walkers, will receive either the drug or a placebo for 48 weeks. The main goal is to…
Phase 3 • Sponsor: Biohaven Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
-
New test could predict falls in muscle disease patients
Diagnosis By invitation onlyThis study aims to create a simple test battery to determine fall risk in people with neuromuscular disorders, such as muscular dystrophy or ALS. Researchers will assess 108 participants using several physical tests like walking, standing, and rising from a chair. The goal is to …
Sponsor: LMU Klinikum • Aim: Diagnosis
Last updated Jun 26, 2026 16:30 UTC
-
New study tests workplace coaching to keep Parkinson's patients on the job
Symptom relief OngoingThis study tests a personalized workplace intervention for 124 Dutch workers with Parkinson's disease, cerebellar ataxia, hereditary spastic paraparesis, or slowly progressive neuromuscular/mitochondrial disorders. A trained facilitator helps employees and their managers identify…
Sponsor: Radboud University Medical Center • Aim: Symptom relief
Last updated Aug 16, 2026 00:00 UTC
-
Robot suit helps kids with movement disorders take steps at home
Symptom relief OngoingThis study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …
Sponsor: MarsiBionics • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
-
A chest belt that maps the lungs could help breathing machines fit better
Knowledge-focused By invitation onlyResearchers at the Royal Free Hospital are testing whether electrical impedance tomography (EIT), a radiation-free imaging method that uses a chest belt and low-level electrical currents, can help clinicians adjust breathing machines for people with chronic respiratory failure. T…
Sponsor: Royal Free Hospital NHS Foundation Trust • Aim: Knowledge-focused
Last updated Sep 11, 2026 00:00 UTC
-
Massive study aims to unlock secrets of childhood nerve and muscle diseases
Knowledge-focused OngoingThis long-term study looks at children and adults with inherited nerve and muscle disorders that start early in life, like muscular dystrophy. Researchers will track symptoms over time and collect genetic samples from affected individuals, their family members, and healthy volunt…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 11, 2026 00:00 UTC
-
Can MRI scans reveal how ANO5 muscle disease progresses?
Knowledge-focused OngoingThis study follows adults with pathogenic variants in the anoctamin 5 gene, which causes a form of limb-girdle muscular dystrophy. Over three years, researchers will use whole-body MRI to measure changes in muscle fat content, and questionnaires to track fatigue and quality of li…
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
-
Vibrating tendons may unlock hidden cycling power, study suggests
Knowledge-focused By invitation onlyThis study tests whether applying mild vibration (100 Hz) to the Achilles and patellar tendons before and during cycling can help athletes generate more power while feeling the same level of effort. Forty healthy student-athletes will ride a stationary bike under three conditions…
Sponsor: Wrocław University of Science and Technology • Aim: Knowledge-focused
Last updated Jul 22, 2026 00:00 UTC
-
Researchers track rare nerve disease to unlock future treatments
Knowledge-focused OngoingThis study follows 20 people with a rare nerve disease called CMT4J for up to 2 years. Researchers will track symptoms and health changes to better understand how the disease progresses. The goal is to find better ways to measure the disease, which could help design future treatm…
Sponsor: Elpida Therapeutics SPC • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
-
Can a VR game make rehab fun for kids with duchenne?
Knowledge-focused By invitation onlyThis study is testing a virtual reality game designed specifically for people with Duchenne muscular dystrophy (DMD). Six participants aged 7 and older will play the game once using a VR headset and hand tracking. Researchers will measure how easy and enjoyable the game is, and w…
Sponsor: Istanbul University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
-
New study aims to uncover why people with muscle disease fall
Knowledge-focused OngoingThis study measures how often people with myotonic dystrophy type 1 fall and what factors affect their balance. Researchers will also assess fear of falling and leg muscle strength. The goal is to better understand fall risk in this condition.
Sponsor: Antalya Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
-
500 patients join quest to unlock mysteries of neuromuscular disease
Knowledge-focused By invitation onlyThis study aims to help doctors diagnose neuromuscular diseases faster and better understand how these conditions progress. Researchers will collect blood, tissue, and imaging data from 500 adults with neuromuscular disease. The goal is to find genetic markers and other clues tha…
Sponsor: Ottawa Hospital Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
-
Big MRI study aims to solve muscle disease diagnosis puzzle
Knowledge-focused By invitation onlyThis study is collecting MRI scans from 1000 people with neuromuscular diseases to see if muscle imaging can help doctors diagnose these conditions more accurately and without invasive biopsies. The goal is to create a large database of MRI patterns linked to specific genetic cau…
Sponsor: Ottawa Hospital Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
-
New headset lets ALS patients type with their brain
Knowledge-focused OngoingThis study is testing a new, comfortable headset that reads brain signals to help people with ALS type on a virtual keyboard. The goal is to improve the device so it can be used in daily life. Five people with ALS will try the headset, and researchers will measure how easy it is …
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC