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A chest belt that maps the lungs could help breathing machines fit better

NCT ID NCT07810283

Knowledge-focused Sponsor: Royal Free Hospital NHS Foundation Trust Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers at the Royal Free Hospital are testing whether electrical impedance tomography (EIT), a radiation-free imaging method that uses a chest belt and low-level electrical currents, can help clinicians adjust breathing machines for people with chronic respiratory failure. The study has two parts: one looks at whether EIT-guided changes to non-invasive ventilation settings help patients use their machines more and feel better, and the other watches how air moves in the lungs during cough assist sessions. About 20 adults with chronic respiratory failure or neuromuscular disease take part, and the team compares measurements before and after one month on the new settings.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
electrical impedance tomography, a radiation-free lung imaging device worn as a chest belt
What this could lead to
If it works, EIT could give clinicians a real-time view of the lungs to tailor breathing machine settings, which may help people tolerate their machines better and spend less time in hospital.
What could go wrong
This is a small feasibility study of about 20 people at one hospital, so it cannot prove that EIT-guided settings improve outcomes. The belt may not produce clear enough pictures, and any benefits seen in this setting may not hold for other patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Work package 1: * Patients diagnosed with chronic respiratory failure * Requiring domiciliary NIV and non-concordant with NIV (\<4hrs/night for 70% in the last 1month) * Age ≥18years Work package 2: * Age ≥18years * Patients diagnosed with a neuromuscular disease * Currently use or have previously used MI:E for clinical use or as part of a research study

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Work package 1: * Patients diagnosed with chronic respiratory failure * Requiring domiciliary NIV and non-concordant with NIV (\<4hrs/night for 70% in the last 1month) * Age ≥18years Work package 2: * Age ≥18years * Patients diagnosed with a neuromuscular disease * Currently use or have previously used MI:E for clinical use or as part of a research study Exclusion Criteria: * Exclusion criteria work package 1: * Unable to provide informed consent * Contraindication to EIT: * Active implantable cardiac device * Active pacemaker * Open wound over the site of the EIT belt * Chest circumference \< 80cm or \> 116cm * Psychosocial factors attributable to non-concordance * Excessive mask leak contributing to non-concordance * Mental health diagnosis contributing to non-concordance * Pregnancy Exclusion criteria work package 2: * Unable to provide informed consent * Contraindication to EIT: * Active implantable cardiac device * Active pacemaker * Open wound over the site of the EIT belt * Chest circumference \< 80cm or \> 116cm * Pregnancy * Evidence of obstructive airways disease FEV1:FVC\<0.7. * Contraindication to MI:E: * Un-drained pneumothorax. * Severe bronchospasm. * Head injury with Intercranial pressure (ICP) \>25 mm Hg. * Severe arterial hypotension (mean arterial pressure \<65 mm Hg). * Tracheoesophageal fistula. * Significant haemoptysis. * Facial fractures. * Vomiting. * Flail segment * Epistaxis within 2 weeks.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset neuromuscular disease Obesity obesity disorder respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD Electrical impedance tomography Neuromuscular disability Non invasive ventilation (NIV) Obesity

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Royal Free Hospital

    London, United Kingdom

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