Myalgic encephalomeyelitis/chronic fatigue syndrome

This study looks at a blood-filtering procedure called immunoadsorption (IA) in 50 people with ME/CFS or Post-COVID syndrome who have certain autoantibodies. The goal is to see if removing these antibodies improves symptoms like severe fatigue and brain fog. Researchers will trac…

This expanded access program offers REGENECYTE, a human umbilical cord blood infusion, to adults with Long COVID who cannot join other clinical trials. Participants must have a recent negative COVID-19 test and provide consent. The goal is to provide potential treatment access wh…

This phase 2 trial is testing whether a butyrate supplement (Cal-Mag Butyrate) can improve physical function in 120 veterans with Gulf War Illness. The study also looks at effects on fatigue, memory, gut health, and inflammation. Participants take the supplement or a placebo for …

This study tests two drugs—pyridostigmine (Mestinon) and low-dose naltrexone (LDN)—alone or together in 160 adults with ME/CFS or Long COVID who also have orthostatic intolerance (difficulty standing). Over 3 months, participants take gradually increasing doses and complete exerc…

This study tests whether a smartphone app that analyzes voice patterns can help diagnose and monitor myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Researchers will compare voice samples from 40 people with ME/CFS and those without to find unique voice signatures. T…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of major depression and chronic pain at the same time. Fifty-four adults with moderate depression and pain will receive 30 sessions of active rTMS over several weeks. Researchers …

This trial tests whether drinking hydrogen-rich water for 16 weeks can reduce fatigue and improve physical functioning in people with ME/CFS (chronic fatigue syndrome). Half of the 80 participants will receive the active supplement, while the other half gets a placebo. The study …

This trial tests whether a program built around small, deliberate choices — called micro-choices — can help people with persistent fatigue, including those with long COVID. Participants attend a four-day group workshop and receive three weeks of digital support to build new habit…

This study tests whether shining low-level laser light on muscles can reduce fatigue and improve quality of life in 40 adults with chronic fatigue syndrome. Participants will receive either real laser therapy or a sham treatment three times a week for eight weeks. Researchers wil…

This study tests whether a testosterone drug (Depo-Testosterone) can reduce fatigue and improve sexual function, mood, and body composition in young men (ages 18-54) who have survived cancer and now have low testosterone. Participants must be in remission for at least one year an…

This study tests whether a special laser (MLS class IV) can reduce chronic pain and fatigue in people with hypermobile Ehlers-Danlos syndrome (hEDS), a condition that causes loose joints and widespread pain. Twenty-five adults will receive 10 laser sessions over 5 weeks, with pai…

This study is testing a mind-body program called DNRS for people with ME/CFS (chronic fatigue syndrome) who may also have Long COVID. The program uses brain retraining to help calm overactive nerves and improve symptoms like fatigue, pain, and mood. Researchers will track quality…

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms like fatigue and brain fog in people with post-COVID syndrome. About 40 adults with long COVID will receive the treatment. The main goal is to see if a la…

This study tests a dietary supplement called lumbrokinase in 120 adults with Long Covid, post-treatment Lyme disease syndrome, or ME/CFS. Participants take the supplement daily for 6 weeks. The goal is to see if it improves overall health and quality of life, as measured by a sim…

This study tests whether personalized exercise and a gentle nerve stimulation device can reduce pain, improve sleep, and ease fatigue in people with fibromyalgia. About 75 adults with fibromyalgia and chronic fatigue will be split into three groups: one gets exercise plus standar…

This study tests whether a 3-day course can improve physical function and reduce fatigue in adults with Chronic Fatigue Syndrome (CFS/ME). Researchers will enroll 100 participants who have a CFS/ME diagnosis and are at least 50% out of school or work. The goal is to see if this s…

This study uses functional MRI to see how the brain processes unpleasant sensations like pain and physical effort in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) compared to healthy volunteers. Researchers will apply mild heat and ask participants to sq…

This study investigates post-exertional malaise (PEM), the hallmark symptom of ME/CFS, where even minor activity triggers severe symptom worsening. Researchers will compare 50 ME/CFS patients with 50 healthy volunteers matched by age, sex, and activity level. Participants undergo…

This study looks at how people with ME/CFS (chronic fatigue syndrome) and people with heart conditions feel after a bike exercise test. Researchers want to see if the type and timing of symptoms after exercise are different between the two groups. 80 adults will take part, and th…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study looks at people who have long-lasting health problems after getting the COVID-19 vaccine, a condition called Post-Acute COVID-19 Vaccination Syndrome (PACVS). Researchers will track symptoms over eight months and test blood and blood vessel function to find biological …

This study observes 200 people with and without ME/CFS to understand the long-term biological changes driving the condition. Researchers will collect samples and track participants over time, focusing on infections and inflammation. No treatments are tested; the goal is to gather…

This study looks at how sleep issues contribute to tiredness and thinking problems in people with multiple sclerosis (MS). About 382 MS patients and a control group without MS will have overnight sleep tests, thinking assessments, and questionnaires. The goal is to better underst…

This study focuses on people with ME/CFS or Long COVID who are too sick to leave home. Researchers will provide monthly in-home medical visits and create personalized care plans. The goal is to see if this approach improves patients' health and eases the burden on their caregiver…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…