Myalgic encephalomeyelitis/chronic fatigue syndrome

This study tested whether a procedure called immunoadsorption — which filters certain antibodies out of the blood — can reduce fatigue in people with chronic fatigue syndrome (ME/CFS), including those whose condition started after COVID-19. Sixty-six adults received either five r…

This study looked at whether a personalized exercise program, started before breast cancer surgery and continued for 12 months after, could prevent lymphedema (arm swelling) and improve recovery. Forty women scheduled for breast cancer surgery took part. They received structured …

This trial tests whether a 12-week ketogenic diet program, delivered entirely online, is practical and acceptable for adults with Long COVID who also have ME/CFS and dysautonomia. Participants follow a low-carb, high-fat diet with vitamin B1 and electrolyte support, plus weekly v…

This study tested whether a gentle, light-touch therapy (therapeutic touch) could help advanced cancer patients in palliative care sleep better and feel less tired. Sixty-one patients were randomly assigned to receive either 5 days of 10-15 minute touch sessions or standard care.…

This completed Phase 3 trial tested whether two widely available drugs—fluvoxamine (an antidepressant) and metformin (a diabetes drug)—can reduce fatigue and other symptoms in people with long COVID. 399 adults with confirmed prior COVID-19 infection and persistent symptoms took …

This study tested whether low-dose naltrexone (LDN) can reduce fatigue and improve related symptoms in people with post-COVID fatigue syndrome. 160 adults who had confirmed COVID-19 and met criteria for post-COVID fatigue took either LDN or a placebo for 16 weeks. The main goal w…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study tested a 12-week self-management program for university students with chronic fatigue. The program taught skills like goal setting, time management, and stress coping. Researchers measured changes in fatigue, sleep quality, resilience, and daily balance. The goal was t…

This completed study tested whether the MIND diet—a mix of Mediterranean and DASH diets—could improve fatigue, quality of life, and brain fog in 62 adults with multiple sclerosis. Participants followed either the MIND diet or a traditional healthy diet for 3 months, with weekly o…

This completed study tested a home-based rehabilitation program for 13 adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The program taught energy management strategies to help participants pace themselves and avoid overexertion. Researchers measured change…

This study tested a device called the Human Regenerator Jet, which emits cold atmospheric plasma, to see if it can improve quality of life in adults with chronic stress, fatigue, pain, or Long COVID. Forty participants received 10 sessions of either the plasma or plain air, and r…

This study tested whether special leg exercises could improve balance, walking, and fatigue in people with multiple sclerosis (MS). Twenty-six adults with MS did either the special exercises or standard leg strengthening for six weeks. The goal was to see if these exercises could…

This completed Phase 4 trial tested two herbal granules, Compound Ciwujia and Guipi, in 235 adults with chronic fatigue syndrome. Participants took the granules for 6 weeks. The main goal was to see if fatigue scores improved. The study also looked at quality of life and traditio…

This study tested whether lisdexamfetamine dimesylate (Vyvanse), a drug used for ADHD, can help with cognitive impairment and fatigue in adults with chronic fatigue syndrome. Twenty-six participants were randomly assigned to receive either Vyvanse or a placebo for six weeks. The …

This study watched 60 adults with ME/CFS (a condition causing severe fatigue) after they received hyperbaric oxygen therapy (HBOT) in a high-pressure chamber. Participants filled out health questionnaires to track changes in physical function and fatigue. The goal was not to prov…

This study looked at 70 family caregivers of stroke patients who also have bladder issues. Researchers measured how much burden, fatigue, poor sleep, and depression caregivers experience. The goal was to understand the challenges these caregivers face, not to test a new treatment…

This study looked at heart and lung function in 106 people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to better understand post-exertional malaise—the severe worsening of symptoms after physical activity. Participants did two maximal exercise tests on consec…

This completed study followed 6,000 adults who had COVID-19 symptoms and were tested for the virus. Participants completed online surveys every 3 months for 18 months to track long-term health issues like fatigue, brain fog, and heart problems. The goal was to better understand t…