Could a common ADHD drug ease chronic fatigue brain fog?

NCT ID NCT01071044

Completed Symptom relief Sponsor: Rochester Center for Behavioral Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether lisdexamfetamine dimesylate (Vyvanse), a drug used for ADHD, can help with cognitive impairment and fatigue in adults with chronic fatigue syndrome. Twenty-six participants were randomly assigned to receive either Vyvanse or a placebo for six weeks. The researchers measured changes in executive function and fatigue levels to see if the drug offered any benefit.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lisdexamfetamine dimesylate (Vyvanse)
What this could lead to: If it works, this could point toward a treatment for the cognitive problems and fatigue that often come with chronic fatigue syndrome.
What could go wrong: This is a small, early-phase study with only 26 participants, so results may not apply to everyone. Stimulants like Vyvanse can cause side effects such as increased heart rate, anxiety, or insomnia.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction myalgic encephalomeyelitis/chronic fatigue syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC FATIGUE SYNDROME COGNITIVE IMPAIRMENTS

Contacts and locations

Locations

Rochester Center for Behavioral Medicine

Rochester Hills, Michigan, 48307, United States

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