Moderate heart failure

This study tests a device called Barostim that stimulates nerves in the neck to help the heart work better. It involves 2,500 adults with moderate heart failure who still have symptoms despite standard treatments. The goal is to see if the device reduces deaths and hospital stays…

This trial tests whether a digital tool that prompts doctors to adjust heart failure medications can improve care. The tool uses home monitoring and patient data to suggest medication changes. The study includes over 1,300 adults with heart failure and will measure hospitalizatio…

This study tests a small sensor implanted in the lung artery that sends daily pressure readings to doctors. It involves 81 adults with advanced heart failure (NYHA Class III). The goal is to see if the device is safe and accurate, helping patients avoid hospital stays by catching…

This study tested a small sensor placed in the lung artery to help doctors monitor heart failure patients remotely. 738 people with advanced (NYHA Class III) heart failure took part. The goal was to see if using the sensor could reduce hospitalizations and deaths compared to a ta…

This study follows 2,500 people with moderate heart failure (NYHA Class II or III) who already have a CardioMEMS sensor implanted in their lung artery. The sensor wirelessly sends pressure readings to doctors, who use the data to adjust medications. Researchers will track surviva…

This study tests whether hearts from donors who died from circulatory death (DCD) are as safe for transplant as hearts from brain-dead donors (DBD). About 40 adult heart transplant recipients will receive either a DCD or DBD heart. The goal is to see if using DCD hearts can safel…

This study looks at whether doing a preventive heart ablation (a procedure to destroy small areas of heart tissue causing irregular rhythms) before LVAD surgery can reduce serious problems like dangerous heart rhythms, death, blood clots, or heart failure in the first 30 days aft…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study tests a one-time gene therapy called AB-1002, given directly into the heart arteries, for people with advanced heart failure (NYHA Class III). The goal is to see if it can improve heart function, reduce symptoms, and lower the risk of death or hospitalization. About 15…

This registry follows 350 adult heart transplant patients whose donor hearts were kept alive and beating using the OCS Heart System before transplant. The goal is to see how well patients do one year after surgery. The device may allow more donor hearts to be used, especially tho…

This study looks at whether existing blood markers can accurately identify the underlying cause of heart failure in 511 patients. Researchers aim to improve diagnosis and potentially reduce healthcare costs by avoiding unnecessary tests. Participants were recently diagnosed with …

This early study tests a device that creates a small, temporary opening in the wall of the heart to relieve pressure and improve symptoms in people with advanced heart failure. The main goal is to see if the procedure is safe. About 20 participants who have not responded well to …

This study looks at whether a quick, simple test—standing up and sitting down from a chair as many times as possible in one minute—can help predict how heart failure patients will fare after leaving the hospital. Researchers will follow 68 adults hospitalized for decompensated he…

This study looks at how SGLT2 inhibitors, a type of diabetes drug also used for heart failure, affect the body's metabolism. About 40 adults with mild to moderate heart failure will have blood tests, walking tests, and calf MRIs before and after starting the medication. The goal …