Meningococcal infection

This study tested a new combination vaccine designed to protect healthy infants against five types of meningococcal bacteria (A, B, C, W, and Y) that can cause serious infections like meningitis. Over 700 infants received different doses or combinations of the vaccine to check sa…

This study looked at how well the MenBVac vaccine protects children against a specific type of meningitis B bacteria. Researchers measured the immune response in 218 children who had already received five doses of the vaccine. The goal was to see if the children had enough antibo…

This study tested whether a fourth dose of the MenBVac vaccine boosts protection against meningitis B in children. Researchers measured immune responses in 120 children before and after the booster. The goal was to see if the vaccine maintains protective antibody levels over time…

This study looked at 117 children aged 4-8 who had received four doses of the MenBVac vaccine against meningitis B. Researchers measured how many still had protective antibodies four years after the last dose. The goal was to see if the vaccine's immunity lasts over time.

This Pfizer study tested a new 5-in-1 vaccine (MenABCWY) that targets five types of meningococcal bacteria, which can cause serious infections like meningitis. The trial involved 309 healthy teens aged 11 to 14 and compared two different dosing schedules (shots 12 months apart vs…

This study looked at whether a booster dose of the meningitis B vaccine (Bexsero) works well and is safe for healthy people aged 10 to 20. It included 312 participants who either got the vaccine as babies or had never received it. The goal was to see if the booster triggers a str…

This study tested a new vaccine (NmCV-5) to protect infants against meningitis, a serious infection of the brain and spine. About 1,325 healthy infants in Mali received either the new vaccine or a standard one at 9 or 15 months old. The goal was to see if the new vaccine works as…

This study looked at whether giving the meningitis B vaccine (Bexsero) and the pneumonia vaccine (PCV13) along with routine baby shots is safe and works well. About 1,200 healthy infants aged 6 to 12 weeks took part. Researchers checked for side effects like pain, redness, fever,…

This study tested a new vaccine (MenACYW) to protect against four types of meningococcal bacteria that can cause meningitis and sepsis. Over 1,500 healthy infants and toddlers in India and South Africa received the vaccine alongside routine childhood shots. Researchers compared i…

This study tested a new investigational vaccine (MenPenta) designed to protect against five types of meningococcal bacteria (A, B, C, W, Y) that cause meningitis and bloodstream infections. Around 1,200 healthy adolescents and adults received either the new vaccine or existing va…

This study tested a new meningitis vaccine (MenACYW) in 840 healthy infants and toddlers. The goal was to see if it works as well as an existing vaccine (Nimenrix) when given as two shots at 6 and 12 months of age. The trial measured immune response and monitored safety to suppor…

This study looked at whether a single booster dose of the MenQuadfi vaccine is safe and effective for healthy toddlers aged 12 to 23 months who had already received a different meningococcal vaccine as infants. The 71 participants in Argentina received one shot and had blood test…

This study tested a single shot of the MenACYW conjugate vaccine (MenQuadfi™) in 447 healthy people aged 12 months and older in Vietnam. The goal was to see how well the vaccine triggers antibodies against four types of meningococcal bacteria and to check for side effects. Partic…

This Phase 3 trial tested a new single-dose vaccine (MenACYW) against an existing one (Menactra) in 360 healthy people aged 2 to 55. The goal was to see if the new vaccine triggers a similar or better immune response to four types of meningococcal bacteria. Results showed the new…

This study tested a booster dose of an experimental meningitis vaccine (MenACYW) in 570 healthy teens and adults who had received a meningitis vaccine 3-6 years earlier. The goal was to see if the booster could restore strong immunity against four types of meningococcal bacteria.…

This phase 3 trial tested a new vaccine (MenACYW) in 707 healthy toddlers aged 12-23 months. The vaccine aims to protect against four types of meningococcal bacteria that can cause meningitis and sepsis. Researchers compared the new vaccine to two existing vaccines (Nimenrix and …

This study tested a new meningitis vaccine (MenQuadfi) in 463 healthy adolescents aged 10 to 17. It compared the new vaccine to an existing one (Nimenrix) and also checked if it could be given at the same time as HPV and Tdap-IPV vaccines. The goal was to see if the new vaccine p…

This study tested a single booster dose of the MenACYW conjugate vaccine in 471 older adults who had received either an older or the same vaccine at least 3 years earlier. The goal was to see if the booster triggered a strong immune response against four meningitis-causing bacter…

This study tested whether a single dose of azithromycin can eliminate meningococcal bacteria from the nose and throat of healthy college students. Over 700 students participated, and researchers checked for bacterial clearance two weeks after treatment. The goal is to find a new …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if the…

This study tested whether a probiotic called Bifidobacterium breve PRL2020 could reduce stomach issues like diarrhea in 121 children aged 3-12 who were taking amoxicillin antibiotics. The children took the probiotic alongside their antibiotic treatment. The goal was to see if it …

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This study looked at how different meningococcal vaccines affect B cells, the white blood cells that produce antibodies. Researchers gave 20 healthy adults aged 30-70 either a polysaccharide or conjugate vaccine and then measured their B cell responses. The goal was to understand…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…