Intestinal fistula

This study compares two ways to treat uncomplicated perianal fistula: conventional open surgery (fistulectomy) and a newer laser ablation technique. About 72 adults with a single, simple fistula tract will be randomly assigned to one of the two procedures. Researchers will track …

This study looks at whether injecting a patient's own fat-derived cells can help close abnormal connections (fistulas) in the gut that won't heal with standard treatments. Researchers will track 50 adults to see what factors predict successful closure. The goal is to understand w…

This Phase 2 trial tests whether E-CEL UVEC Cells, a type of genetically engineered cell, can treat perianal fistula—a painful tunnel that forms near the anus. The treatment involves injecting the cells directly into the fistula tract in a minimally invasive procedure. Researcher…

This pilot study tests whether a device that delivers controlled heat (radiofrequency ablation) can safely close perianal fistulas—abnormal tunnels between the anal canal and skin. Eighty adults with certain types of fistulas will receive a single RFA treatment. Researchers will …

This study compares three surgical techniques for treating a common type of anal fistula (a tunnel between the anal canal and skin). The trial will enroll 90 adults aged 18-65 who have not had fistula surgery before. Researchers will measure healing, recurrence, and impact on bow…

This study will check how well MRI can find and map perianal fistulas before surgery. Thirty patients with suspected fistulas will get an MRI, and the results will be compared to what surgeons find during the operation. The goal is to see if MRI can help doctors plan better surge…

This study tests whether doing pelvic floor exercises (called anal lift exercises) and changing diet early after anal fistula surgery can help reduce pain, bleeding, and discomfort. About 124 adults aged 18 to 55 who have had anal fistula surgery will be split into two groups: on…

This study tests whether injecting platelet-rich plasma (PRP) into the wound after fistulotomy surgery for simple anal fistula can speed healing and reduce pain. About 70 adults aged 18-65 with simple low anal fistulas will be randomly assigned to get either standard surgery plus…

This study will follow 120 women having surgery for common anal conditions like fissures, hemorrhoids, or fistulas. Researchers want to see if their sexual function improves after surgery. Participants will fill out questionnaires before surgery and at 3 and 6 months after. The g…

This study will observe 90 adults with anal fistulas to see if the time between first symptoms and surgery affects healing and recurrence. Participants are grouped by how long they waited: 3 months or less, 3 to 6 months, or more than 6 months. Researchers will track healing, rec…

This study tests whether using the 'teach-back' method—where patients repeat back what they've learned—improves understanding and reduces readmissions after same-day anal fistula surgery. Half of the 76 participants will get this interactive education, while the other half receiv…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…