Antibiotics after abscess drainage may block painful fistula formation

NCT ID NCT07704359

Not yet recruiting Disease control Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This trial tests whether a 7-day course of antibiotics after draining a first-time perianal abscess can stop an anal fistula from forming. Adults with a first abscess are randomly assigned to receive antibiotics or not, then followed for up to 12 months. The goal is to see if antibiotics lower the chance of developing this abnormal tunnel between the anal canal and skin.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antibiotics (amoxicillin/clavulanate or ciprofloxacin plus metronidazole)
What this could lead to: If it works, this could become a standard way to prevent anal fistulas after a first abscess, reducing the need for further surgery.
What could go wrong: This is a single trial with 236 participants, so results may not apply to everyone. Antibiotics can cause side effects like diarrhea or allergic reactions.

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Conditions

The condition(s) this trial relates to.

Surgical Wound anal fistula prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANAL FISTULA PERIANAL ABSCESS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

University of Illinois at Chicago

Chicago, Illinois, 60612, United States

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