Inherited auditory system disease

This phase 3 trial tests whether an experimental drug called KP-100IT, injected into the spinal fluid, can help people with severe acute spinal cord injuries regain function. Participants, aged 18 to 89 with a complete loss of motor and sensory function (AIS grade A), receive fiv…

This trial tests whether a newer head-and-body movement, called Semont-plus, works better than the standard Epley maneuver for treating a common type of vertigo caused by loose crystals in the inner ear. Adults with posterior canal BPPV will be randomly assigned to one of the two…

This early-stage trial tests a new cell therapy called Rincell-1 for adults with certain types of hearing loss who are getting a cochlear implant. The study will compare the safety and early effectiveness of receiving the cell therapy plus the implant versus the implant alone. Ab…

This trial tests whether two self-assessment methods in a smartphone app can generate hearing aid settings that match those from a standard hearing test. Adults with perceived mild-to-moderate hearing loss will use the app to self-test their hearing and also undergo conventional …

This study tests a surgical procedure called endoscopic stapedotomy for people with otosclerosis, a condition that causes progressive hearing loss. Surgeons will use a tiny camera to place a small artificial device in the middle ear to improve sound transmission. The study will f…

This pilot study tests a new imaging system that uses OCT and vibrometry to let doctors see the middle ear bones and measure how they move in response to sound. The study enrolls 500 adults with conductive or sensorineural hearing loss. The goal is to compare these detailed motio…

This trial tests whether chewing sugar-free gum for 20 minutes, alongside standard intravenous medication, can reduce dizziness and nausea in adults with a common inner-ear condition called posterior canal BPPV. Participants are randomly assigned to either chew gum or receive sta…

This study tests whether Ai Chi, a slow, controlled water exercise program, can help people with long-term dizziness from inner ear problems. 38 adults will either do standard home exercises or add Ai Chi sessions in a pool over 4 weeks. Researchers will measure changes in balanc…

This study tests whether special eye and balance exercises can reduce dizziness, motion sickness, and improve quality of life in people with inner-ear balance problems. Thirty-two adults with motion sickness or vertigo will do either standard habituation exercises or a new optoki…

This study tests whether rimegepant, a drug used for migraines, can quickly reduce dizziness from conditions like vestibular migraine. About 370 adults with moderate to severe dizziness will receive either rimegepant plus betahistine or betahistine alone. The main goal is to see …

This study compares two ways to insert a cochlear implant: using a robotic device or the standard manual method. Researchers want to see which approach leads to better hearing one year after surgery. The study will enroll 32 adults with hearing loss, randomly assigning them to on…

This study tests a new care pathway for adults getting a cochlear implant. Instead of the usual nine clinic visits in the first year, the new plan uses early activation of the implant and remote monitoring visits. The goal is to see if this approach is at least as good for hearin…

This study investigates how often changes in the OTOF gene are linked to auditory neuropathy spectrum disorder (ANSD), a condition where sound enters the ear but the brain has trouble processing it. Researchers will analyze the DNA of 30 people with non-syndromic ANSD using whole…

This study looks back at the medical records of 200 people who received a SONATA 2 cochlear implant. The goal is to understand how well the implant works over time in real-world settings, including speech recognition in quiet and noisy environments. Researchers will also analyze …

This study will measure balance, coordination, and reaction time in 41 adults aged 18-40 who experience motion sickness. Participants will complete a series of physical tests and a controlled motion sickness provocation session. The goal is to see how these sensorimotor skills re…

This study looks at 10 adults over 50 with hearing loss and one weak balance ear. It compares implanting the device in the weak-balance ear versus the good-balance ear. The goal is to see if choosing the weaker side helps reduce dizziness after surgery.