Goiter

This study tested an investigational drug called VRDN-001 in 143 people with thyroid eye disease who did not improve in earlier studies. The drug aims to reduce inflammation and eye bulging by blocking a specific receptor. Researchers measured how many participants had at least a…

This Phase 3 trial tested an investigational drug called veligrotug (VRDN-001) in 188 people with chronic thyroid eye disease. The drug is an antibody that blocks a protein involved in the disease. The main goal was to see if it could reduce eye bulging (proptosis) compared to a …

This study tested a drug called batoclimab in 35 adults with Graves' disease whose thyroid hormone levels were still high despite taking standard antithyroid drugs. The goal was to see if batoclimab could help bring those levels back to normal or below over 24 weeks. Batoclimab w…

This completed Phase 3 trial tested a drug called VRDN-001 in 231 people with thyroid eye disease (TED). The drug works by blocking a receptor involved in inflammation and swelling. The main goal was to check safety and tolerability, with secondary goals including measuring chang…

This trial tests whether veligrotug, an antibody that blocks a receptor involved in inflammation, can reduce eye bulging and swelling in people with active thyroid eye disease. Participants receive five infusions of the drug or a placebo. The study measures how many people see a …

This study looked at whether a tea made from wild blackberry root could improve thyroid health in people with Graves' disease, an autoimmune condition that causes an overactive thyroid. Forty-two adults with newly diagnosed or relapsed Graves' disease drank either the blackberry …

This study looked at whether tocilizumab, a drug that calms the immune system, can help people with active moderate-to-severe thyroid eye disease that did not get better with steroids. Thirty-two adults received the drug every four weeks. Researchers measured improvements in eye …

This study tested whether artificial intelligence (AI) can improve the accuracy of contrast-enhanced ultrasound for diagnosing thyroid nodules. Nearly 2,000 participants had both an ultrasound and a biopsy to confirm their diagnosis. Researchers compared how well doctors could id…

This study looked at two approaches to giving iodine supplements to pregnant women. One group received a daily iodine pill from 14 weeks until delivery. The other group had their urine iodine tested first; only those with low levels got iodine, while others got an iron pill. The …

This study compares two needle sizes (21-gauge vs 27-gauge) used for ultrasound-guided fine needle biopsy of thyroid nodules. The goal is to see which size causes less pain and discomfort during the procedure while still collecting enough cells for diagnosis. Adults with thyroid …

This study looked at whether removing benign thyroid nodules without placing a surgical drain is safe and effective. Eighty adults having thyroid surgery were randomly assigned to either the standard drain or a no-drain, sutureless technique. The goal was to see if the no-drain a…

This study tested a special recovery program (ERAS) for people having thyroid surgery. The goal was to see if it could reduce pain, nausea, and time spent in the hospital compared to usual care. 143 adults took part, and the program focused on improving comfort and speeding up re…

This study compared two types of thyroid surgery: one using a microscope and the standard approach. Researchers looked at blood loss, nerve damage, and low calcium levels after surgery in 74 patients with thyroid cancer or other thyroid conditions. The goal was to see if the micr…

This study tested whether doing gentle neck exercises for 10 days after thyroid surgery could reduce pain and improve quality of life. 93 adults who had their thyroid removed were split into two groups: one did the exercises, the other received standard care. Researchers measured…

This study tested whether spraying a blue dye called methylene blue onto tissues during thyroid surgery helps surgeons better see and protect the nerve that controls voice and the glands that regulate calcium. 136 adults with benign thyroid nodules took part. The goal was to redu…

This study tested whether adding dexmedetomidine to a standard nerve block (superficial cervical plexus block) improves pain control after thyroid surgery. Fifty-eight adults undergoing thyroid surgery were randomly assigned to receive the nerve block with or without dexmedetomid…

This study tested whether applying oxidized regenerated cellulose and hyaluronic acid during thyroid surgery can prevent painful adhesions that often form after the procedure. 45 adults with benign goiter or thyroid cancer were enrolled. The goal was to see if these barriers redu…

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This study examines whether patients who have a thyroid nodule found on a PET scan can safely skip a follow-up ultrasound without affecting their survival. Researchers will compare death rates over 7 years between those who had an ultrasound within 3 months and those who did not.…

This study investigates whether measuring ionized calcium levels before, during, and after total thyroidectomy can predict which patients will develop low calcium levels (hypocalcemia) after surgery. Researchers will track calcium and parathyroid hormone levels in 327 adults unde…

This study looked at whether giving iodine supplements to pregnant women helps their children's brain development. Researchers tested 85 children at age 2 using a standard developmental assessment. The goal was to see if iodine, which is often low in French diets, makes a differe…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study tested whether a parvovirus infection might trigger Graves' disease, an autoimmune condition affecting the thyroid. Researchers compared 52 people—half recently diagnosed with Graves' disease and half with thyroid nodules or goiter—by checking their blood for parvoviru…

This study tested a digital conversation aid to help patients and doctors make shared decisions about thyroid biopsy. Researchers enrolled 107 adults with thyroid nodules to see if using the tool during clinic visits was practical. The goal was to gather information for planning …

This study looked at how much iodine breastfeeding mothers need each day. Seventeen healthy mother-infant pairs took different doses of iodine supplements for five days. Researchers measured iodine levels in urine, blood, and breast milk to figure out the right daily amount for b…